Gene Name	WWOX
Gene ID	51741
Gene Full Name	WW domain containing oxidoreductase
Gene Alias	D16S432E|DEE28|EIEE28|FOR|FRA16D|HHCMA56|PRO0128|SCAR12|SDR41C1|WOX1
Transcripts	ENSG00000186153
Virus	HBV
Gene Type	protein-coding
HPA Location Info	Golgi apparatus;Nucleoplasm, Cytosol;
Membrane Info	Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins
Uniport_ID	Q9NZC7
HGNC ID	HGNC:12799
OMIM ID	605131
Summary	This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1004307	chr16	15	36	34	85	View
1005120	chr16	26	18	20	64	View
1005604	chr16	21	15	15	51	View
1006328	chr16	13	15	12	40	View
1006541	chr16	30	1	6	37	View
1006552	chr16	2	33	1	36	View
1007468	chr16	10	8	9	27	View
1011657	chr16	8	0	0	8	View
1012865	chr16	5	1	0	6	View
1020185	chr16	1	3	1	5	View
1022994	chr16	15	36	34	85	View
1024073	chr16	0	2	1	3	View
1024397	chr16	0	2	1	3	View
1024736	chr16	15	0	0	15	View
1041172	chr16	7	3	0	10	View
1042210	chr16	8	0	0	8	View

Data ID	Experiment type	Sample number	Platform
GSE236281	RNA-seq	12	Illumina MiSeq (Homo sapiens)
C   GSE35465	Chip-seq;RNA-seq	6	Illumina HiSeq 2000 (Homo sapiens)
C   GSE68402	Chip-seq	26	Illumina MiSeq (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens)
S   GSE247322	scRNA-seq	27	Illumina NovaSeq 6000 (Homo sapiens)
TCGA_LIHC_HBV	DNA methylation sequencing;RNA-seq	97	TCGA
C   GSE270130	Chip-seq	27	Illumina NovaSeq 6000 (Homo sapiens)
GSE224901	RNA-seq	21	Illumina NovaSeq 6000 (Homo sapiens)
GSE100400	Chip-seq;RNA-seq;4C_cccDNA	31	Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (Mus musculus)
GSE173897	RNA-seq	95	Illumina HiSeq 4000 (Homo sapiens)
GSE262515	RNA-seq	21	Illumina HiSeq 2500 (Homo sapiens);Illumina HiSeq 2500 (Mus musculus)
GSE110345	RNA-seq	4	Illumina HiSeq 2500 (Homo sapiens)
C   GSE131257	ATAC-seq;RNA-seq	19	Illumina HiSeq 2500 (Homo sapiens)
GSE94660	RNA-seq	42	Illumina HiSeq 2500 (Homo sapiens)

• scRNA data
• Genome binding/occupancy profiling

When the query gene is differentially changed in the dataset, a feature/violin plot will be displayed.

> Dataset: GSE247322 - Gene expression in cell subsets