HTLV1 Target gene Detail Information

> WWOX Gene Search Result


Gene Information
Gene Name WWOX
Gene ID 51741
Gene Full Name WW domain containing oxidoreductase
Gene Alias D16S432E|DEE28|EIEE28|FOR|FRA16D|HHCMA56|PRO0128|SCAR12|SDR41C1|WOX1
Transcripts ENSG00000186153
Virus HTLV1
Gene Type protein-coding
HPA Location Info Golgi apparatus;Nucleoplasm, Cytosol;
Membrane Info Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins
Uniport_ID Q9NZC7
HGNC ID HGNC:12799
OMIM ID 605131
Summary This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Target gene [WWOX] related to VISs

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section


DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6003438 chr16 6 17 137 160 View
6003439 chr16 6 17 137 160 View
6005946 chr16 2 22 54 78 View
6007619 chr16 46 2 5 53 View
6007737 chr16 47 1 4 52 View
6009132 chr16 38 1 0 39 View
6011837 chr16 22 3 0 25 View
6012505 chr16 20 2 0 22 View
6014853 chr16 14 1 0 15 View
6015701 chr16 1 4 8 13 View
6018980 chr16 1 7 0 8 View
6019959 chr16 6 1 0 7 View
6022250 chr16 5 0 0 5 View
6028711 chr16 0 1 0 1 View
6029628 chr16 0 1 0 1 View
6032832 chr16 0 0 0 0 View

Target gene [WWOX] related to Omics data
Data ID Experiment type Sample number Platform
GSE189602 Methylation profiling (Array) 4 Infinium MethylationEPIC
C
  GSE94732 		Chip-seq 24 Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens)
GSE52244 Expression array 15 [HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version]
GSE10789 Expression array 6 NCI/ATC Hs-OperonV3
GSE224047 RNA-seq 10 Illumina NextSeq 500 (Homo sapiens)
GSE168557 Expression array 6 Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Feature Number version)
GSE136189 Methylation profiling (Array) 40 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482);Illumina Infinium HumanMethylation850 BeadChip


When the gene can detect a peak in the dataset, a peak plot will be displayed.


> Dataset: GSE94732 - WWOX peak across samples

Peak Plot