Gene Information
|
Gene Name
|
CD8A |
|
Gene ID
|
925
|
|
Gene Full Name
|
CD8 subunit alpha |
|
Gene Alias
|
CD8|CD8alpha|IMD116|Leu2|p32 |
|
Transcripts
|
ENSG00000153563
|
|
Virus
|
IV |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Plasma membrane;Intracellular and membrane; 
|
|
Membrane Info
|
CD markers, Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins |
|
Uniport_ID
|
P01732
|
|
HGNC ID
|
HGNC:1706
|
|
OMIM ID
|
186910 |
|
Summary
|
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. The major protein isoforms of this gene differ by the presence or absence of a transmembrane domain and thus differ in being a membrane-anchored or secreted protein. [provided by RefSeq, May 2020] |
Target gene [CD8A] related to virus gene/protein/region 
Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section
Target gene [CD8A] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
S GSE243629
|
scRNA-seq |
11 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
C GSE225706
|
Chip-seq |
6 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE135069
|
RNA-seq |
10 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
C GSE113702
|
Chip-seq |
52 |
Illumina NextSeq 500 (Homo sapiens);Illumina HiSeq 4000 (Homo sapiens) |
|
GSE162632
|
scRNA-seq |
292 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
C GSE225704
|
ATAC-seq |
3 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
E C GSE156060
|
Chip-seq;RNA-seq |
28 |
Illumina NovaSeq 6000 (Homo sapiens) |
When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.
> Dataset: GSE156060 - CD8A expression across samples
|
Volcano Plot
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Bar Plot
|
|
|
IV Target gene Detail Information
