Virus Dataset Detail

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Dataset Information
Accession GSE243629
Status 2023/9/21
Title A single-cell atlas of the peripheral immune response in patients with influenza A virus infection
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Influenza A virus (IAV) continues to be a critical global health problem, especially for vulnerable populations such as children and pregnant women. While certain circulating cell subsets are thought to differentially modulate the immune response to IAV infection, the nature and function of these subsets is unclear. Our findings provide a comprehensive understanding of the cellular subtypes and molecular characteristics of PBMCs across different populations with IAV infection. By revealing significant differences in immune responses to IAV among these populations, our study could aid in the development of immune intervention measures to control IAV and improve patient outcomes.
Samples
GSM ID Sample info Characteristics Description
GSM7792037 IC_1, replicate 1, scRNAseq tissue:Peripheral blood; cell line:PBMC; age:4; Sex:male; genotype:CRCh38 Singleron
GSM7792038 IC_2, replicate 2, scRNAseq tissue:Peripheral blood; cell line:PBMC; age:5; Sex:male; genotype:CRCh38 Singleron
GSM7792039 IA_1, replicate 1, scRNAseq tissue:Peripheral blood; cell line:PBMC; age:20; Sex:male; genotype:CRCh38 Singleron
GSM7792040 IA_2, replicate 2, scRNAseq tissue:Peripheral blood; cell line:PBMC; age:27; Sex:female; genotype:CRCh38 Singleron
GSM7792041 PI_1, replicate 1, scRNAseq tissue:Peripheral blood; cell line:PBMC; age:27; Sex:female; genotype:CRCh38 Singleron
GSM7792042 PI_2, replicate 2, scRNAseq tissue:Peripheral blood; cell line:PBMC; age:28; Sex:female; genotype:CRCh38 Singleron
GSM7792043 PI_3, replicate 3, scRNAseq tissue:Peripheral blood; cell line:PBMC; age:25; Sex:female; genotype:CRCh38 Singleron
GSM7792044 PHC_1, replicate 1, scRNAseq tissue:Peripheral blood; cell line:PBMC; age:27; Sex:female; genotype:CRCh38 Singleron
GSM7792045 PHC_2, replicate 2, scRNAseq tissue:Peripheral blood; cell line:PBMC; age:36; Sex:female; genotype:CRCh38 Singleron
GSM7792046 HC_1, replicate 1, scRNAseq tissue:Peripheral blood; cell line:PBMC; age:29; Sex:female; genotype:CRCh38 Singleron
GSM7792047 HC_2, replicate 2, scRNAseq tissue:Peripheral blood; cell line:PBMC; age:20; Sex:male; genotype:CRCh38 Singleron
Platform GPL24676  : Illumina NovaSeq 6000 (Homo sapiens)
Literature 38089584  
Download Download scRNA Analysis Data  
scRNA-seq UMAP