Gene Name	CREB1
Gene ID	1385
Gene Full Name	cAMP responsive element binding protein 1
Gene Alias	CREB|CREB-1
Transcripts	ENSG00000118260
Virus	HTLV1
Gene Type	protein-coding
HPA Location Info	Nucleoplasm;Centrosome, Basal body;
Membrane Info	Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors
Uniport_ID	P16220
HGNC ID	HGNC:2345
OMIM ID	123810
Summary	This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	26516904	H43P	tax	tax	HTLV-1 Infection Carrier State	S C L T	View
2	9710589	K85A	tax	tax	Cell line	T	View
3	9710589	K88A	tax	tax	Cell line	T	View
4	9710589	R82A	tax	tax	Cell line	T	View
5	9710589	V89A	tax	tax	Cell line	T	View
6	11080799	K88A	tax	tax	Cell line	T	View
7	11080799	L90A	tax	tax	Cell line	T	View
8	11080799	V89A	tax	tax	Cell line	T	View
9	8970957	A204S	tax	tax	Cell line	T	View
10	8970957	C29A	tax	tax	Cell line	T	View
11	8970957	G177S	tax	tax	Cell line	T	View
12	8970957	G203A	tax	tax	Cell line	T	View
13	8970957	H127S	tax	tax	Cell line	T	View
14	8970957	L124S	tax	tax	Cell line	T	View
15	8970957	L131S	tax	tax	Cell line	T	View
16	8970957	L146S	tax	tax	Cell line	T	View
17	8970957	L319R	tax	tax	Cell line	T	View
18	8970957	L320S	tax	tax	Cell line	T	View
19	8970957	P176A	tax	tax	Cell line	T	View
20	8970957	P30S	tax	tax	Cell line	T	View
21	8970957	Q126A	tax	tax	Cell line	T	View
22	8970957	T123A	tax	tax	Cell line	T	View
23	8970957	T130A	tax	tax	Cell line	T	View
24	8970957	T145A	tax	tax	Cell line	T	View
25	10567539	L319R	tax	tax	Cell line	T	View
26	10567539	L320S	tax	tax	Cell line	T	View
27	10567539	S318A	tax	tax	Cell line	T	View
28	10698501	K88A	tax	tax	Cell line	T	View
29	10734308	K88A	tax	tax	Cell line	T	View
30	10766811	K88A	tax	tax	Cell line	T	View
31	10766811	L319R	tax	tax	Cell line	T	View
32	10766811	L320S	tax	tax	Cell line	T	View
33	10766811	V89A	tax	tax	Cell line	T	View

Data ID	Experiment type	Sample number	Platform
GSE189602	Methylation profiling (Array)	4	Infinium MethylationEPIC
C   GSE94732	Chip-seq	24	Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens)
GSE52244	Expression array	15	[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version]
GSE19080	Expression array	38	Homo sapiens 3K Immunoarray2 HTLV-1 JH
GSE10789	Expression array	6	NCI/ATC Hs-OperonV3
GSE224047	RNA-seq	10	Illumina NextSeq 500 (Homo sapiens)
GSE168557	Expression array	6	Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Feature Number version)
GSE136189	Methylation profiling (Array)	40	Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482);Illumina Infinium HumanMethylation850 BeadChip

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE94732 - CREB1 peak across samples

Peak Plot