HTLV1 Target gene Detail Information

> DPYD Gene Search Result


Gene Information
Gene Name DPYD
Gene ID 1806
Gene Full Name dihydropyrimidine dehydrogenase
Gene Alias DHP|DHPDHASE|DPD|DYPD
Transcripts ENSG00000188641
Virus HTLV1
Gene Type protein-coding
HPA Location Info
Membrane Info Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins
Uniport_ID Q12882
HGNC ID HGNC:3012
OMIM ID 612779
Summary The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Target gene [DPYD] related to VISs

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section


DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6000464 chr1 7 915 590 1512 View
6007040 chr1 25 13 22 60 View
6013076 chr1 17 2 1 20 View
6016872 chr1 4 7 0 11 View
6022975 chr1 3 0 1 4 View
6024004 chr1 2 0 2 4 View
6028589 chr1 1 0 0 1 View
6030767 chr1 0 0 0 0 View

Target gene [DPYD] related to Omics data
Data ID Experiment type Sample number Platform
GSE189602 Methylation profiling (Array) 4 Infinium MethylationEPIC
C
  GSE94732 		Chip-seq 24 Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens)
GSE52244 Expression array 15 [HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version]
GSE19080 Expression array 38 Homo sapiens 3K Immunoarray2 HTLV-1 JH
GSE10789 Expression array 6 NCI/ATC Hs-OperonV3
GSE224047 RNA-seq 10 Illumina NextSeq 500 (Homo sapiens)
GSE168557 Expression array 6 Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Feature Number version)
GSE136189 Methylation profiling (Array) 40 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482);Illumina Infinium HumanMethylation850 BeadChip


When the gene can detect a peak in the dataset, a peak plot will be displayed.


> Dataset: GSE94732 - DPYD peak across samples

Peak Plot