Gene Name	FHIT
Gene ID	2272
Gene Full Name	fragile histidine triad diadenosine triphosphatase
Gene Alias	AP3Aase|FRA3B
Transcripts	ENSG00000189283
Virus	HBV
Gene Type	protein-coding
HPA Location Info	Nucleoli fibrillar center, Plasma membrane;
Membrane Info	Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Uniport_ID	P49789
HGNC ID	HGNC:3701
OMIM ID	601153
Summary	The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage. [provided by RefSeq, Aug 2017]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1004550	chr3	67	6	4	77	View
1005083	chr3	24	27	10	61	View
1006191	chr3	4	28	10	42	View
1014029	chr3	3	0	1	4	View
1017368	chr3	1	0	0	1	View
1017506	chr3	0	0	0	0	View
1017617	chr3	0	0	0	0	View
1018069	chr3	0	0	0	0	View
1019855	chr3	0	0	0	0	View
1020743	chr3	0	0	0	0	View
1020744	chr3	67	6	4	77	View
1041355	chr3	1	0	0	1	View
1042761	chr3	3	4	0	7	View
1042762	chr3	0	1	0	1	View
1042763	chr3	139	10	4	153	View
1042764	chr3	0	0	0	0	View

Data ID	Experiment type	Sample number	Platform
GSE252863	scRNA-seq	10	Illumina HiSeq 2500 (Homo sapiens)
GSE236281	RNA-seq	12	Illumina MiSeq (Homo sapiens)
C   GSE35465	Chip-seq;RNA-seq	6	Illumina HiSeq 2000 (Homo sapiens)
C   GSE68402	Chip-seq	26	Illumina MiSeq (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens)
S   GSE247322	scRNA-seq	27	Illumina NovaSeq 6000 (Homo sapiens)
TCGA_LIHC_HBV	DNA methylation sequencing;RNA-seq	97	TCGA
C   GSE270130	Chip-seq	27	Illumina NovaSeq 6000 (Homo sapiens)
GSE224901	RNA-seq	21	Illumina NovaSeq 6000 (Homo sapiens)
E   C   GSE100400	Chip-seq;RNA-seq;4C_cccDNA	31	Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (Mus musculus)
GSE173897	RNA-seq	95	Illumina HiSeq 4000 (Homo sapiens)
GSE262515	RNA-seq	21	Illumina HiSeq 2500 (Homo sapiens);Illumina HiSeq 2500 (Mus musculus)
GSE110345	RNA-seq	4	Illumina HiSeq 2500 (Homo sapiens)
C   GSE131257	ATAC-seq;RNA-seq	19	Illumina HiSeq 2500 (Homo sapiens)
E   GSE94660	RNA-seq	42	Illumina HiSeq 2500 (Homo sapiens)

• Expression profiling
• scRNA data
• Genome binding/occupancy profiling

When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.

> Dataset: GSE100400 - FHIT expression across samples

Volcano Plot

Bar Plot

> Dataset: GSE94660 - FHIT expression across samples

Volcano Plot

Bar Plot