HTLV1 Target gene Detail Information

> FHIT Gene Search Result


Gene Information
Gene Name FHIT
Gene ID 2272
Gene Full Name fragile histidine triad diadenosine triphosphatase
Gene Alias AP3Aase|FRA3B
Transcripts ENSG00000189283
Virus HTLV1
Gene Type protein-coding
HPA Location Info Nucleoli fibrillar center, Plasma membrane;
Membrane Info Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Uniport_ID P49789
HGNC ID HGNC:3701
OMIM ID 601153
Summary The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage. [provided by RefSeq, Aug 2017]
Target gene [FHIT] related to VISs

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section


DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6005462 chr3 72 14 1 87 View
6006987 chr3 32 14 15 61 View
6010067 chr3 29 4 0 33 View
6010297 chr3 11 19 2 32 View
6011514 chr3 8 16 2 26 View
6012740 chr3 12 1 8 21 View
6013559 chr3 12 4 3 19 View
6013656 chr3 16 2 0 18 View
6014014 chr3 15 1 1 17 View
6015320 chr3 11 3 0 14 View
6017070 chr3 9 2 0 11 View
6019736 chr3 5 2 0 7 View
6023429 chr3 2 2 0 4 View
6023739 chr3 4 0 0 4 View
6023840 chr3 2 2 0 4 View
6024121 chr3 2 1 1 4 View
6024383 chr3 3 0 0 3 View
6024982 chr3 3 0 0 3 View
6025138 chr3 1 2 0 3 View
6025682 chr3 2 0 1 3 View
6025933 chr3 1 1 0 2 View
6026347 chr3 1 0 1 2 View
6026602 chr3 2 0 0 2 View
6028603 chr3 1 0 0 1 View
6028823 chr3 0 1 0 1 View
6030959 chr3 0 0 0 0 View

Target gene [FHIT] related to Omics data
Data ID Experiment type Sample number Platform
GSE189602 Methylation profiling (Array) 4 Infinium MethylationEPIC
C
  GSE94732 		Chip-seq 24 Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens)
GSE52244 Expression array 15 [HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version]
GSE19080 Expression array 38 Homo sapiens 3K Immunoarray2 HTLV-1 JH
GSE224047 RNA-seq 10 Illumina NextSeq 500 (Homo sapiens)
GSE168557 Expression array 6 Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Feature Number version)
GSE136189 Methylation profiling (Array) 40 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482);Illumina Infinium HumanMethylation850 BeadChip


When the gene can detect a peak in the dataset, a peak plot will be displayed.


> Dataset: GSE94732 - FHIT peak across samples

Peak Plot