Gene Name	HLA-DRB1
Gene ID	3123
Gene Full Name	major histocompatibility complex, class II, DR beta 1
Gene Alias	DRB1|HLA-DR1B|HLA-DRB|SS1
Transcripts	ENSG00000196126
Virus	HBV
Gene Type	protein-coding
HPA Location Info
Membrane Info	Disease related genes, Human disease related genes, Plasma proteins, Predicted membrane proteins
Uniport_ID	P01911
HGNC ID	HGNC:4948
OMIM ID	142857
Summary	HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and some alleles have increased frequencies associated with certain diseases or conditions. For example, DRB1*1302 has been related to acute and chronic hepatitis B virus persistence. There are multiple pseudogenes of this gene. [provided by RefSeq, Jul 2020]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	38037048	A1762T	EnhII;BCP;PreC	C	Carcinoma, Hepatocellular Hepatitis B, Chronic Liver Cirrhosis	G C L T	View
2	38037048	A1846T	EnhII;BCP;PreC	C	Carcinoma, Hepatocellular Hepatitis B, Chronic Liver Cirrhosis	G C L T	View
3	38037048	C1653T	EnhII;BCP;PreC	C	Carcinoma, Hepatocellular Hepatitis B, Chronic Liver Cirrhosis	G C L T	View
4	38037048	G1719T	EnhII;BCP;PreC	C	Carcinoma, Hepatocellular Hepatitis B, Chronic Liver Cirrhosis	G C L T	View
5	38037048	G1764A	EnhII;BCP;PreC	C	Carcinoma, Hepatocellular Hepatitis B, Chronic Liver Cirrhosis	G C L T	View
6	38037048	G1896A	EnhII;BCP;PreC	C	Carcinoma, Hepatocellular Hepatitis B, Chronic Liver Cirrhosis	G C L T	View
7	38037048	G1899A	EnhII;BCP;PreC	C	Carcinoma, Hepatocellular Hepatitis B, Chronic Liver Cirrhosis	G C L T	View
8	38037048	T1674C	EnhII;BCP;PreC	C	Carcinoma, Hepatocellular Hepatitis B, Chronic Liver Cirrhosis	G C L T	View
9	38037048	T1674G	EnhII;BCP;PreC	C	Carcinoma, Hepatocellular Hepatitis B, Chronic Liver Cirrhosis	G C L T	View
10	38037048	T1753A	EnhII;BCP;PreC	C	Carcinoma, Hepatocellular Hepatitis B, Chronic Liver Cirrhosis	G C L T	View
11	38037048	T1753C	EnhII;BCP;PreC	C	Carcinoma, Hepatocellular Hepatitis B, Chronic Liver Cirrhosis	G C L T	View

Data ID	Experiment type	Sample number	Platform
S   GSE252863	scRNA-seq	10	Illumina HiSeq 2500 (Homo sapiens)
GSE236281	RNA-seq	12	Illumina MiSeq (Homo sapiens)
S   GSE199850	scRNA-seq	1	HiSeq X Ten (Homo sapiens)
C   GSE68402	Chip-seq	26	Illumina MiSeq (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens)
S   GSE247322	scRNA-seq	27	Illumina NovaSeq 6000 (Homo sapiens)
TCGA_LIHC_HBV	DNA methylation sequencing;RNA-seq	97	TCGA
C   GSE270130	Chip-seq	27	Illumina NovaSeq 6000 (Homo sapiens)
GSE224901	RNA-seq	21	Illumina NovaSeq 6000 (Homo sapiens)
E   GSE100400	Chip-seq;RNA-seq;4C_cccDNA	31	Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (Mus musculus)
GSE173897	RNA-seq	95	Illumina HiSeq 4000 (Homo sapiens)
GSE262515	RNA-seq	21	Illumina HiSeq 2500 (Homo sapiens);Illumina HiSeq 2500 (Mus musculus)
GSE110345	RNA-seq	4	Illumina HiSeq 2500 (Homo sapiens)
GSE131257	ATAC-seq;RNA-seq	19	Illumina HiSeq 2500 (Homo sapiens)
GSE94660	RNA-seq	42	Illumina HiSeq 2500 (Homo sapiens)

• Expression profiling
• scRNA data
• Genome binding/occupancy profiling

When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.

> Dataset: GSE100400 - HLA-DRB1 expression across samples

Volcano Plot

Bar Plot