Gene Name	MAP2K3
Gene ID	5606
Gene Full Name	mitogen-activated protein kinase kinase 3
Gene Alias	MAPKK3|MEK3|MKK3|PRKMK3|SAPKK-2|SAPKK2
Transcripts	ENSG00000034152
Virus	HBV
Gene Type	protein-coding
HPA Location Info	Nucleoplasm, Cytosol;
Membrane Info	Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Uniport_ID	P46734
HGNC ID	HGNC:6843
OMIM ID	602315
Summary	The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1004548	chr17	75	1	1	77	View
1012367	chr17	7	0	0	7	View
1013060	chr17	5	0	0	5	View
1020859	chr17	5	0	0	5	View
1023500	chr17	75	1	1	77	View
1024847	chr17	2	3	0	5	View
1042258	chr17	27	2	0	29	View

Data ID	Experiment type	Sample number	Platform
GSE252863	scRNA-seq	10	Illumina HiSeq 2500 (Homo sapiens)
GSE236281	RNA-seq	12	Illumina MiSeq (Homo sapiens)
C   GSE35465	Chip-seq;RNA-seq	6	Illumina HiSeq 2000 (Homo sapiens)
C   GSE68402	Chip-seq	26	Illumina MiSeq (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens)
GSE247322	scRNA-seq	27	Illumina NovaSeq 6000 (Homo sapiens)
TCGA_LIHC_HBV	DNA methylation sequencing;RNA-seq	97	TCGA
C   GSE270130	Chip-seq	27	Illumina NovaSeq 6000 (Homo sapiens)
GSE224901	RNA-seq	21	Illumina NovaSeq 6000 (Homo sapiens)
GSE100400	Chip-seq;RNA-seq;4C_cccDNA	31	Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (Mus musculus)
GSE173897	RNA-seq	95	Illumina HiSeq 4000 (Homo sapiens)
GSE262515	RNA-seq	21	Illumina HiSeq 2500 (Homo sapiens);Illumina HiSeq 2500 (Mus musculus)
GSE110345	RNA-seq	4	Illumina HiSeq 2500 (Homo sapiens)
C   GSE131257	ATAC-seq;RNA-seq	19	Illumina HiSeq 2500 (Homo sapiens)
GSE94660	RNA-seq	42	Illumina HiSeq 2500 (Homo sapiens)

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE35465 - MAP2K3 peak across samples

Peak Plot

> Dataset: GSE68402 - MAP2K3 peak across samples

Peak Plot

> Dataset: GSE270130 - MAP2K3 peak across samples

Peak Plot

> Dataset: GSE131257 - MAP2K3 peak across samples

Peak Plot