HTLV1 Target gene Detail Information

> MAP4K4 Gene Search Result


Gene Information
Gene Name MAP4K4
Gene ID 9448
Gene Full Name mitogen-activated protein kinase kinase kinase kinase 4
Gene Alias FLH21957|HEL-S-31|HGK|MEKKK4|NIK
Transcripts ENSG00000071054
Virus HTLV1
Gene Type protein-coding
HPA Location Info
Membrane Info Enzymes, Plasma proteins, Predicted intracellular proteins
Uniport_ID O95819
HGNC ID HGNC:6866
OMIM ID 604666
Summary The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Target gene [MAP4K4] related to VISs

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section


DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6003838 chr2 46 92 1 139 View
6009977 chr2 32 1 1 34 View
6011341 chr2 27 0 0 27 View
6012452 chr2 20 1 1 22 View
6016408 chr2 1 11 0 12 View

Target gene [MAP4K4] related to Omics data
Data ID Experiment type Sample number Platform
C
  GSE94732 		Chip-seq 24 Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens)
GSE52244 Expression array 15 [HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version]
GSE19080 Expression array 38 Homo sapiens 3K Immunoarray2 HTLV-1 JH
GSE10789 Expression array 6 NCI/ATC Hs-OperonV3
GSE224047 RNA-seq 10 Illumina NextSeq 500 (Homo sapiens)
GSE189602 Methylation profiling (Array) 4 Infinium MethylationEPIC
GSE136189 Methylation profiling (Array) 40 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482);Illumina Infinium HumanMethylation850 BeadChip


When the gene can detect a peak in the dataset, a peak plot will be displayed.


> Dataset: GSE94732 - MAP4K4 peak across samples

Peak Plot