Gene Information
|
Gene Name
|
MTOR |
|
Gene ID
|
2475
|
|
Gene Full Name
|
mechanistic target of rapamycin kinase |
|
Gene Alias
|
FRAP|FRAP1|FRAP2|RAFT1|RAPT1|SKS |
|
Transcripts
|
ENSG00000198793
|
|
Virus
|
MCV |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Golgi apparatus, Cytosol; 
|
|
Membrane Info
|
Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
|
Uniport_ID
|
P42345
|
|
HGNC ID
|
HGNC:3942
|
|
OMIM ID
|
601231 |
|
Summary
|
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This kinase is a component of two distinct complexes, mTORC1, which controls protein synthesis, cell growth and proliferation, and mTORC2, which is a regulator of the actin cytoskeleton, and promotes cell survival and cell cycle progression. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Inhibitors of mTOR are used in organ transplants as immunosuppressants, and are being evaluated for their therapeutic potential in SARS-CoV-2 infections. Mutations in this gene are associated with Smith-Kingsmore syndrome and somatic focal cortical dysplasia type II. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Aug 2020] |
Target gene [MTOR] related to virus gene/protein/region 
Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section
Target gene [MTOR] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
C GSE147406
|
Chip-seq |
39 |
Illumina NextSeq 500 (Homo sapiens) |
|
C GSE124856
|
Chip-seq |
8 |
Illumina NextSeq 500 (Homo sapiens) |
|
GSE136867
|
scRNA-seq |
2 |
Illumina NextSeq 500 (Homo sapiens) |
|
C GSE69877
|
Chip-seq |
10 |
Illumina HiSeq 2000 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens) |
|
C GSE230758
|
Chip-seq |
20 |
Illumina HiSeq 2500 (Homo sapiens) |
When the gene can detect a peak in the dataset, a peak plot will be displayed.
> Dataset: GSE147406 - MTOR peak across samples
|
Peak Plot
|
> Dataset: GSE124856 - MTOR peak across samples
|
Peak Plot
|
> Dataset: GSE69877 - MTOR peak across samples
|
Peak Plot
|
> Dataset: GSE230758 - MTOR peak across samples
|
Peak Plot
|
|
|
MCV Target gene Detail Information
