| Accession |
GSE136867
|
| Status |
2019/9/5 |
| Title |
Conversion of Sox2-Dependent Merkel Cell Carcinoma to a Differentiated Neuron-like Phenotype by T Antigen Inhibition |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing |
| Summary |
Keratinocyte-cocultured Merkel cell carcinoma cell line (MCC) CVG-1 cells transduced with contorl shRNA (shCtrl) and viral T antigen targeting shRNA (shpanT) were sequenced using the 10x Genomics platform in order to analyze transcriptional changes associated with MCC cancer cell differentiation into neuron-like cells on a single cell level. |
| Samples |
| GSM ID |
Sample info |
Characteristics |
Description |
|
GSM4059983
|
Keratinocyte-cocultured CVG1 with shpanT |
tissue:Merkel cell carcinoma cell line CVG-1 cocultured with keratinocytes; shRNA transduced into mcc cells:shpanT that targets pan viral T antigen transcripts |
CVG-1 cells transduced with shpanT were cocultred with primary human keratinocytes |
|
GSM4059982
|
Keratinocyte-cocultured CVG1 with shCtrl |
tissue:Merkel cell carcinoma cell line CVG-1 cocultured with keratinocytes; shRNA transduced into mcc cells:shCtrl control shRNA |
CVG-1 cells transduced with shCtrl were cocultred with primary human keratinocytes |
|
| Platform |
GPL18573 : Illumina NextSeq 500 (Homo sapiens) |
| Literature |
31527246 |
| Download |
Download scRNA Analysis Data
|
|
scRNA-seq UMAP
|
|
Virus Dataset Detail
