Gene Name	MYCBP2
Gene ID	23077
Gene Full Name	MYC binding protein 2
Gene Alias	Myc-bp2|PAM|PHR1|Phr
Transcripts	ENSG00000005810
Virus	HTLV1
Gene Type	protein-coding
HPA Location Info	Nucleoplasm;Vesicles, Cytosol;
Membrane Info	Enzymes, Metabolic proteins, Predicted intracellular proteins
Uniport_ID	O75592
HGNC ID	HGNC:23386
OMIM ID	610392
Summary	This gene encodes an E3 ubiquitin-protein ligase and member of the PHR (Phr1/MYCBP2, highwire and RPM-1) family of proteins. The encoded protein plays a role in axon guidance and synapse formation in the developing nervous system. In mammalian cells, this protein regulates the cAMP and mTOR signaling pathways, and may additionally regulate autophagy. Reduced expression of this gene has been observed in acute lymphoblastic leukemia patients and a mutation in this gene has been identified in patients with a rare inherited vision defect. [provided by RefSeq, Mar 2017]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6022434	chr13	4	1	0	5	View
6023354	chr13	2	2	0	4	View
6029421	chr13	0	1	0	1	View
6030561	chr13	0	0	0	0	View
6031613	chr13	0	0	0	0	View

Data ID	Experiment type	Sample number	Platform
GSE189602	Methylation profiling (Array)	4	Infinium MethylationEPIC
C   GSE94732	Chip-seq	24	Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens)
GSE52244	Expression array	15	[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version]
E   GSE19080	Expression array	38	Homo sapiens 3K Immunoarray2 HTLV-1 JH
GSE10789	Expression array	6	NCI/ATC Hs-OperonV3
GSE224047	RNA-seq	10	Illumina NextSeq 500 (Homo sapiens)
GSE168557	Expression array	6	Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Feature Number version)
GSE136189	Methylation profiling (Array)	40	Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482);Illumina Infinium HumanMethylation850 BeadChip

• Expression profiling
• Genome binding/occupancy profiling

When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.

> Dataset: GSE19080 - MYCBP2 expression across samples

Volcano Plot

Bar Plot