Gene Information
|
Gene Name
|
NCOA2 |
|
Gene ID
|
10499
|
|
Gene Full Name
|
nuclear receptor coactivator 2 |
|
Gene Alias
|
GRIP1|KAT13C|NCoA-2|SRC2|TIF2|bHLHe75 |
|
Transcripts
|
ENSG00000140396
|
|
Virus
|
HTLV1 |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Nucleoplasm, Nuclear bodies; 
|
|
Membrane Info
|
Cancer-related genes, Disease related genes, Metabolic proteins, Predicted intracellular proteins, Transcription factors |
|
Uniport_ID
|
Q15596
|
|
HGNC ID
|
HGNC:7669
|
|
OMIM ID
|
601993 |
|
Summary
|
The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. This gene has been found to be involved in translocations that result in fusions with other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] |
Target gene [NCOA2] related to VISs 
Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section
| DVID |
Chromosome |
HM |
TFBS |
CA |
Sum of Overlapped Records |
Detail |
| 6005166 |
chr8 |
66 |
27 |
1 |
94 |
View |
| 6009104 |
chr8 |
36 |
2 |
1 |
39 |
View |
| 6017487 |
chr8 |
8 |
0 |
2 |
10 |
View |
| 6033089 |
chr8 |
0 |
0 |
0 |
0 |
View |
Target gene [NCOA2] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
GSE189602
|
Methylation profiling (Array) |
4 |
Infinium MethylationEPIC |
|
C GSE94732
|
Chip-seq |
24 |
Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens) |
|
GSE52244
|
Expression array |
15 |
[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version] |
|
GSE19080
|
Expression array |
38 |
Homo sapiens 3K Immunoarray2 HTLV-1 JH |
|
GSE10789
|
Expression array |
6 |
NCI/ATC Hs-OperonV3 |
|
GSE224047
|
RNA-seq |
10 |
Illumina NextSeq 500 (Homo sapiens) |
|
GSE168557
|
Expression array |
6 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Feature Number version) |
|
GSE136189
|
Methylation profiling (Array) |
40 |
Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482);Illumina Infinium HumanMethylation850 BeadChip |
When the gene can detect a peak in the dataset, a peak plot will be displayed.
> Dataset: GSE94732 - NCOA2 peak across samples
|
Peak Plot
|
|
|
HTLV1 Target gene Detail Information
