Gene Name	NRXN1
Gene ID	9378
Gene Full Name	neurexin 1
Gene Alias	Hs.22998|PTHSL2|SCZD17
Transcripts	ENSG00000179915
Virus	HTLV1
Gene Type	protein-coding
HPA Location Info	Plasma membrane;Intracellular and membrane;
Membrane Info	Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Uniport_ID	P58400, Q9ULB1
HGNC ID	HGNC:8008
OMIM ID	600565
Summary	This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca(2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3,000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for this gene in the 3' region. Mutations in this gene are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia. [provided by RefSeq, Aug 2016]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6000883	chr2	545	60	149	754	View
6004012	chr2	4	123	5	132	View
6006350	chr2	7	61	2	70	View
6009433	chr2	5	16	16	37	View
6011275	chr2	19	8	0	27	View
6017755	chr2	0	7	3	10	View
6019046	chr2	8	0	0	8	View
6019194	chr2	1	5	2	8	View
6025552	chr2	0	0	3	3	View
6025870	chr2	0	2	0	2	View
6027112	chr2	2	0	0	2	View
6028556	chr2	1	0	0	1	View
6029092	chr2	1	0	0	1	View
6030591	chr2	0	0	0	0	View
6031699	chr2	0	0	0	0	View
6031757	chr2	0	0	0	0	View
6033061	chr2	0	0	0	0	View
6033068	chr2	0	0	0	0	View
6033528	chr2	0	0	0	0	View

Data ID	Experiment type	Sample number	Platform
GSE189602	Methylation profiling (Array)	4	Infinium MethylationEPIC
C   GSE94732	Chip-seq	24	Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens)
GSE52244	Expression array	15	[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version]
GSE19080	Expression array	38	Homo sapiens 3K Immunoarray2 HTLV-1 JH
GSE10789	Expression array	6	NCI/ATC Hs-OperonV3
GSE168557	Expression array	6	Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Feature Number version)
GSE136189	Methylation profiling (Array)	40	Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482);Illumina Infinium HumanMethylation850 BeadChip

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE94732 - NRXN1 peak across samples

Peak Plot