Gene Information
|
Gene Name
|
PBX1 |
|
Gene ID
|
5087
|
|
Gene Full Name
|
PBX homeobox 1 |
|
Gene Alias
|
CAKUHED |
|
Transcripts
|
ENSG00000185630
|
|
Virus
|
HTLV1 |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Nucleoplasm;Nuclear bodies, Cytosol; 
|
|
Membrane Info
|
Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors |
|
Uniport_ID
|
P40424
|
|
HGNC ID
|
HGNC:8632
|
|
OMIM ID
|
176310 |
|
Summary
|
This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis and required for skeletal patterning and programming. A chromosomal translocation, t(1;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017] |
Target gene [PBX1] related to VISs 
Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section
| DVID |
Chromosome |
HM |
TFBS |
CA |
Sum of Overlapped Records |
Detail |
| 6012704 |
chr1 |
18 |
3 |
0 |
21 |
View |
| 6015352 |
chr1 |
9 |
5 |
0 |
14 |
View |
| 6015364 |
chr1 |
13 |
1 |
0 |
14 |
View |
| 6023490 |
chr1 |
3 |
0 |
1 |
4 |
View |
| 6024069 |
chr1 |
0 |
4 |
0 |
4 |
View |
| 6027682 |
chr1 |
0 |
2 |
0 |
2 |
View |
| 6027747 |
chr1 |
2 |
0 |
0 |
2 |
View |
| 6031706 |
chr1 |
0 |
0 |
0 |
0 |
View |
Target gene [PBX1] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
GSE189602
|
Methylation profiling (Array) |
4 |
Infinium MethylationEPIC |
|
C GSE94732
|
Chip-seq |
24 |
Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens) |
|
GSE52244
|
Expression array |
15 |
[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version] |
|
GSE19080
|
Expression array |
38 |
Homo sapiens 3K Immunoarray2 HTLV-1 JH |
|
GSE224047
|
RNA-seq |
10 |
Illumina NextSeq 500 (Homo sapiens) |
|
GSE168557
|
Expression array |
6 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Feature Number version) |
|
GSE136189
|
Methylation profiling (Array) |
40 |
Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482);Illumina Infinium HumanMethylation850 BeadChip |
When the gene can detect a peak in the dataset, a peak plot will be displayed.
> Dataset: GSE94732 - PBX1 peak across samples
|
Peak Plot
|
|
|
HTLV1 Target gene Detail Information
