HTLV1 Target gene Detail Information

> PDE4B Gene Search Result


Gene Information
Gene Name PDE4B
Gene ID 5142
Gene Full Name phosphodiesterase 4B
Gene Alias DPDE4|PDEIVB
Transcripts ENSG00000184588
Virus HTLV1
Gene Type protein-coding
HPA Location Info Golgi apparatus, Cytosol;Primary cilium;
Membrane Info Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Uniport_ID Q07343
HGNC ID HGNC:8781
OMIM ID 600127
Summary This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Target gene [PDE4B] related to VISs

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section


DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6012216 chr1 12 8 3 23 View
6019891 chr1 7 0 0 7 View
6020116 chr1 4 3 0 7 View
6020673 chr1 4 2 0 6 View
6023595 chr1 3 1 0 4 View
6026603 chr1 1 1 0 2 View
6032139 chr1 0 0 0 0 View
6033626 chr1 2 17 0 19 View
6033627 chr1 2 10 3 15 View
6033628 chr1 8 5 16 29 View
6033629 chr1 1225 444 273 1942 View
6033630 chr1 16 17 46 79 View
6033631 chr1 31 1 2 34 View
6033632 chr1 12 0 0 12 View
6033633 chr1 68 13 1 82 View

Target gene [PDE4B] related to Omics data
Data ID Experiment type Sample number Platform
GSE189602 Methylation profiling (Array) 4 Infinium MethylationEPIC
C
  GSE94732 		Chip-seq 24 Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens)
GSE52244 Expression array 15 [HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version]
GSE19080 Expression array 38 Homo sapiens 3K Immunoarray2 HTLV-1 JH
GSE224047 RNA-seq 10 Illumina NextSeq 500 (Homo sapiens)
GSE168557 Expression array 6 Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Feature Number version)
GSE136189 Methylation profiling (Array) 40 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482);Illumina Infinium HumanMethylation850 BeadChip


When the gene can detect a peak in the dataset, a peak plot will be displayed.


> Dataset: GSE94732 - PDE4B peak across samples

Peak Plot