Gene Information
|
Gene Name
|
PIK3CA |
|
Gene ID
|
5290
|
|
Gene Full Name
|
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
|
Gene Alias
|
CCM4|CLAPO|CLOVE|CWS5|HMH|MCAP|MCM|MCMTC|PI3K|PI3K-alpha|p110-alpha |
|
Transcripts
|
ENSG00000121879
|
|
Virus
|
HTLV1 |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Primary cilium, Cytosol;Microtubules, Mitochondria; 
|
|
Membrane Info
|
Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins |
|
Uniport_ID
|
P42336
|
|
HGNC ID
|
HGNC:8975
|
|
OMIM ID
|
171834 |
|
Summary
|
Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. A pseudogene of this gene has been defined on chromosome 22. [provided by RefSeq, Apr 2016] |
Target gene [PIK3CA] related to VISs 
Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section
| DVID |
Chromosome |
HM |
TFBS |
CA |
Sum of Overlapped Records |
Detail |
| 6004511 |
chr3 |
109 |
0 |
4 |
113 |
View |
| 6010177 |
chr3 |
29 |
3 |
0 |
32 |
View |
| 6016140 |
chr3 |
12 |
1 |
0 |
13 |
View |
Target gene [PIK3CA] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
GSE189602
|
Methylation profiling (Array) |
4 |
Infinium MethylationEPIC |
|
C GSE94732
|
Chip-seq |
24 |
Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens) |
|
GSE52244
|
Expression array |
15 |
[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version] |
|
GSE19080
|
Expression array |
38 |
Homo sapiens 3K Immunoarray2 HTLV-1 JH |
|
GSE10789
|
Expression array |
6 |
NCI/ATC Hs-OperonV3 |
|
GSE224047
|
RNA-seq |
10 |
Illumina NextSeq 500 (Homo sapiens) |
|
GSE168557
|
Expression array |
6 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Feature Number version) |
|
GSE136189
|
Methylation profiling (Array) |
40 |
Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482);Illumina Infinium HumanMethylation850 BeadChip |
When the gene can detect a peak in the dataset, a peak plot will be displayed.
> Dataset: GSE94732 - PIK3CA peak across samples
|
Peak Plot
|
|
|
HTLV1 Target gene Detail Information
