Gene Information
|
Gene Name
|
PTPRM |
|
Gene ID
|
5797
|
|
Gene Full Name
|
protein tyrosine phosphatase receptor type M |
|
Gene Alias
|
PTPRL1|R-PTP-MU|RPTPM|RPTPU|hR-PTPu |
|
Transcripts
|
ENSG00000173482
|
|
Virus
|
HTLV1 |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Plasma membrane; 
|
|
Membrane Info
|
Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
|
Uniport_ID
|
P28827
|
|
HGNC ID
|
HGNC:9675
|
|
OMIM ID
|
176888 |
|
Summary
|
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. [provided by RefSeq, Jul 2008] |
Target gene [PTPRM] related to VISs 
Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section
| DVID |
Chromosome |
HM |
TFBS |
CA |
Sum of Overlapped Records |
Detail |
| 6006190 |
chr18 |
58 |
14 |
1 |
73 |
View |
| 6007139 |
chr18 |
15 |
33 |
11 |
59 |
View |
| 6017579 |
chr18 |
9 |
1 |
0 |
10 |
View |
| 6018250 |
chr18 |
9 |
0 |
0 |
9 |
View |
| 6020193 |
chr18 |
7 |
0 |
0 |
7 |
View |
| 6021874 |
chr18 |
5 |
0 |
0 |
5 |
View |
| 6023030 |
chr18 |
4 |
0 |
0 |
4 |
View |
| 6025751 |
chr18 |
3 |
0 |
0 |
3 |
View |
| 6027073 |
chr18 |
2 |
0 |
0 |
2 |
View |
| 6030056 |
chr18 |
1 |
0 |
0 |
1 |
View |
| 6030813 |
chr18 |
0 |
0 |
0 |
0 |
View |
| 6031051 |
chr18 |
0 |
0 |
0 |
0 |
View |
| 6031331 |
chr18 |
0 |
0 |
0 |
0 |
View |
Target gene [PTPRM] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
GSE189602
|
Methylation profiling (Array) |
4 |
Infinium MethylationEPIC |
|
C GSE94732
|
Chip-seq |
24 |
Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens) |
|
GSE52244
|
Expression array |
15 |
[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version] |
|
GSE19080
|
Expression array |
38 |
Homo sapiens 3K Immunoarray2 HTLV-1 JH |
|
GSE224047
|
RNA-seq |
10 |
Illumina NextSeq 500 (Homo sapiens) |
|
GSE168557
|
Expression array |
6 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Feature Number version) |
|
GSE136189
|
Methylation profiling (Array) |
40 |
Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482);Illumina Infinium HumanMethylation850 BeadChip |
When the gene can detect a peak in the dataset, a peak plot will be displayed.
> Dataset: GSE94732 - PTPRM peak across samples
|
Peak Plot
|
|
|
HTLV1 Target gene Detail Information
