Gene Information
|
Gene Name
|
SKP2 |
|
Gene ID
|
6502
|
|
Gene Full Name
|
S-phase kinase associated protein 2 |
|
Gene Alias
|
FBL1|FBXL1|FLB1|p45 |
|
Transcripts
|
ENSG00000145604
|
|
Virus
|
MCV |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Nucleoplasm, Cytosol;Nucleoli; 
|
|
Membrane Info
|
Cancer-related genes, Predicted intracellular proteins |
|
Uniport_ID
|
Q13309
|
|
HGNC ID
|
HGNC:10901
|
|
OMIM ID
|
601436 |
|
Summary
|
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2011] |
Target gene [SKP2] related to virus gene/protein/region 
Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section
Target gene [SKP2] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
C GSE147406
|
Chip-seq |
39 |
Illumina NextSeq 500 (Homo sapiens) |
|
C GSE124856
|
Chip-seq |
8 |
Illumina NextSeq 500 (Homo sapiens) |
|
GSE117988
|
scRNA-seq |
6 |
Illumina HiSeq 2500 (Homo sapiens) |
|
C GSE69877
|
Chip-seq |
10 |
Illumina HiSeq 2000 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens) |
|
C GSE230758
|
Chip-seq |
20 |
Illumina HiSeq 2500 (Homo sapiens) |
|
GSE118056
|
scRNA-seq |
4 |
Illumina NovaSeq 6000 (Homo sapiens) |
When the gene can detect a peak in the dataset, a peak plot will be displayed.
> Dataset: GSE147406 - SKP2 peak across samples
|
Peak Plot
|
> Dataset: GSE124856 - SKP2 peak across samples
|
Peak Plot
|
> Dataset: GSE69877 - SKP2 peak across samples
|
Peak Plot
|
> Dataset: GSE230758 - SKP2 peak across samples
|
Peak Plot
|
|
|
MCV Target gene Detail Information
