Virus Dataset Detail

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Dataset Information
Accession GSE117988
Status 2018/9/1
Title scRNAseq reveals mechanisms of Merkel cell carcinoma acquired immunotherapy resistance [1]
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Serial blood draws from a single patient and serial tumor biopsies from the same patient with metastatic Merkel cell polyomavirus Merkel cell carcinoma, who was treated with cellular immunotherapy targeting MCPyV (autologous endogenous T cell therapy) followed by checkpoint inhibitors (anti-PD1 and anti-CTLA4). The patient had a 22 month clinical response followed by late/acquired resistance. We performed scRNAseq using the 10x genomics 3' Chromium expression assay to determine potential mechanisms contributing to immunotherapy response and late resistance
Samples
GSM ID Sample info Characteristics Description
GSM3330559 Tumor Disc Pre tissue:Merkel Cell Carcinoma Tumor; time point:PreRx; chromium index:SI-GA-A2 PreRx MCC Tumor Digest;raw.expMatrix_Tumor.csv
GSM3330560 Tumor Disc AR tissue:Merkel Cell Carcinoma Tumor; time point:Day+615; chromium index:SI-GA-A3 Acquired Resistance Tumor Digest;raw.expMatrix_Tumor.csv
GSM3330561 PBMC Pre tissue:PBMC; time point:PreRx; chromium index:SI-GA-A7 PreRx Peripheral Blood;raw.expMatrix_PBMC.csv
GSM3330562 PBMC Disc Early tissue:PBMC; time point:Day+27; chromium index:SI-GA-A4 Early PostRx Peripheral Blood;raw.expMatrix_PBMC.csv
GSM3330563 PBMC Disc Resp tissue:PBMC; time point:Day+376; chromium index:SI-GA-A5 Responding PostRx Peripheral Blood;raw.expMatrix_PBMC.csv
GSM3330564 PBMC Disc AR tissue:PBMC; time point:Day+614; chromium index:SI-GA-A6 Acquired Resistance Peripheral Blood;raw.expMatrix_PBMC.csv
Platform GPL16791  : Illumina HiSeq 2500 (Homo sapiens)
Literature 30250229  
Download Download scRNA Analysis Data  
scRNA-seq UMAP