Gene Information
|
Gene Name
|
SLIT2 |
|
Gene ID
|
9353
|
|
Gene Full Name
|
slit guidance ligand 2 |
|
Gene Alias
|
SLIL3|Slit-2 |
|
Transcripts
|
ENSG00000145147
|
|
Virus
|
HTLV1 |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Secreted in other tissues; 
|
|
Membrane Info
|
Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters |
|
Uniport_ID
|
O94813
|
|
HGNC ID
|
HGNC:11086
|
|
OMIM ID
|
603746 |
|
Summary
|
This gene encodes a member of the slit family of secreted glycoproteins, which are ligands for the Robo family of immunoglobulin receptors. Slit proteins play highly conserved roles in axon guidance and neuronal migration and may also have functions during other cell migration processes including leukocyte migration. Members of the slit family are characterized by an N-terminal signal peptide, four leucine-rich repeats, nine epidermal growth factor repeats, and a C-terminal cysteine knot. Proteolytic processing of this protein gives rise to an N-terminal fragment that contains the four leucine-rich repeats and five epidermal growth factor repeats and a C-terminal fragment that contains four epidermal growth factor repeats and the cysteine knot. Both full length and cleaved proteins are secreted extracellularly and can function in axon repulsion as well as other specific processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015] |
Target gene [SLIT2] related to VISs 
Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section
| DVID |
Chromosome |
HM |
TFBS |
CA |
Sum of Overlapped Records |
Detail |
| 6008535 |
chr4 |
26 |
14 |
4 |
44 |
View |
| 6016042 |
chr4 |
5 |
6 |
2 |
13 |
View |
| 6017552 |
chr4 |
0 |
8 |
2 |
10 |
View |
| 6021962 |
chr4 |
2 |
2 |
1 |
5 |
View |
| 6022193 |
chr4 |
1 |
4 |
0 |
5 |
View |
Target gene [SLIT2] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
GSE189602
|
Methylation profiling (Array) |
4 |
Infinium MethylationEPIC |
|
C GSE94732
|
Chip-seq |
24 |
Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens) |
|
GSE52244
|
Expression array |
15 |
[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version] |
|
GSE19080
|
Expression array |
38 |
Homo sapiens 3K Immunoarray2 HTLV-1 JH |
|
GSE10789
|
Expression array |
6 |
NCI/ATC Hs-OperonV3 |
|
GSE168557
|
Expression array |
6 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Feature Number version) |
|
GSE136189
|
Methylation profiling (Array) |
40 |
Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482);Illumina Infinium HumanMethylation850 BeadChip |
When the gene can detect a peak in the dataset, a peak plot will be displayed.
> Dataset: GSE94732 - SLIT2 peak across samples
|
Peak Plot
|
|
|
HTLV1 Target gene Detail Information
