Gene Name	TP53
Gene ID	7157
Gene Full Name	tumor protein p53
Gene Alias	BCC7|BMFS5|LFS1|P53|TRP53
Transcripts	ENSG00000141510
Virus	HBV
Gene Type	protein-coding
HPA Location Info	Nucleoplasm;Vesicles, Cytosol;
Membrane Info	Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transcription factors, Transporters
Uniport_ID	P04637
HGNC ID	HGNC:11998
OMIM ID	191170
Summary	This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	37735836	A181T	RT	P	Hepatitis B, Chronic Carcinoma, Hepatocellular	D I C L T	View
2	20962085	M120V	PreS2	S	Carcinoma, Hepatocellular	G S C L T	View
3	20962085	F141L	PreS2	S	Carcinoma, Hepatocellular	G S C L T	View
4	31601912	T1762A	BCP		Occult HBV Infection	G R C L T	View
5	31601912	M130K	X	X	Occult HBV Infection	G R C L T	View
6	21438026	K130M	X	X		G T	View
7	21438026	V131I	X	X		G T	View
8	21438026	A1762T	BCP			G T	View
9	21438026	G1764A	BCP			G T	View
10	17622616	P101S	X	X	Hepatitis B Virus Infection	T	View
11	17622616	K130M	X	X	Hepatitis B Virus Infection	T	View
12	17622616	M130K	X	X	Hepatitis B Virus Infection	T	View
13	25567052	A1762T	Core Promoter		Hepatitis B Virus Infection	G T	View
14	25567052	G1764A	Core Promoter		Hepatitis B Virus Infection	G T	View
15	25567052	T1753A	Core Promoter		Hepatitis B Virus Infection	G T	View
16	25567052	T1768A	Core Promoter		Hepatitis B Virus Infection	G T	View

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1005080	chr17	54	7	0	61	View
1005169	chr17	55	4	0	59	View
1005201	chr17	54	4	0	58	View
1021149	chr17	54	4	0	58	View
1021150	chr17	55	4	0	59	View
1021151	chr17	54	7	0	61	View
1042227	chr17	54	4	0	58	View

Data ID	Experiment type	Sample number	Platform
GSE252863	scRNA-seq	10	Illumina HiSeq 2500 (Homo sapiens)
GSE236281	RNA-seq	12	Illumina MiSeq (Homo sapiens)
TCGA_LIHC_HBV	DNA methylation sequencing;RNA-seq	97	TCGA
GSE270937	DNA methylation sequencing	35	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE270130	Chip-seq	27	Illumina NovaSeq 6000 (Homo sapiens)
GSE224901	RNA-seq	21	Illumina NovaSeq 6000 (Homo sapiens)
E   GSE100400	Chip-seq;RNA-seq;4C_cccDNA	31	Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (Mus musculus)
GSE173897	RNA-seq	95	Illumina HiSeq 4000 (Homo sapiens)
GSE262515	RNA-seq	21	Illumina HiSeq 2500 (Homo sapiens);Illumina HiSeq 2500 (Mus musculus)
GSE110345	RNA-seq	4	Illumina HiSeq 2500 (Homo sapiens)
GSE131257	ATAC-seq;RNA-seq	19	Illumina HiSeq 2500 (Homo sapiens)
GSE94660	RNA-seq	42	Illumina HiSeq 2500 (Homo sapiens)

• Expression profiling
• Genome binding/occupancy profiling

When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.

> Dataset: GSE100400 - TP53 expression across samples

Volcano Plot

Bar Plot