Gene Information
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Gene Name
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BCL2L1 |
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Gene ID
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598
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Gene Full Name
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BCL2 like 1 |
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Gene Alias
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BCL-XL/S|BCL2L|BCLX|Bcl-X|PPP1R52 |
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Transcripts
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ENSG00000171552
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Virus
|
MCV |
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Gene Type
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protein-coding |
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HPA Location Info
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Mitochondria;Nucleoli fibrillar center, Acrosome; 
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Membrane Info
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Cancer-related genes, Predicted membrane proteins, RAS pathway related proteins, Transporters |
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Uniport_ID
|
Q07817
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HGNC ID
|
HGNC:992
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OMIM ID
|
600039 |
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Summary
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The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. [provided by RefSeq, Dec 2015] |
Target gene [BCL2L1] related to VISs 
Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section
Target gene [BCL2L1] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
C GSE147406
|
Chip-seq |
39 |
Illumina NextSeq 500 (Homo sapiens) |
|
C GSE124856
|
Chip-seq |
8 |
Illumina NextSeq 500 (Homo sapiens) |
|
GSE136867
|
scRNA-seq |
2 |
Illumina NextSeq 500 (Homo sapiens) |
|
GSE226438
|
scRNA-seq |
11 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
S GSE117988
|
scRNA-seq |
6 |
Illumina HiSeq 2500 (Homo sapiens) |
|
C GSE69877
|
Chip-seq |
10 |
Illumina HiSeq 2000 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens) |
|
C GSE230758
|
Chip-seq |
20 |
Illumina HiSeq 2500 (Homo sapiens) |
|
S GSE118056
|
scRNA-seq |
4 |
Illumina NovaSeq 6000 (Homo sapiens) |
When the query gene is differentially changed in the dataset, a feature/violin plot will be displayed.
> Dataset: GSE117988 - Gene expression in cell subsets
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> Dataset: GSE118056 - Gene expression in cell subsets
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MCV Target gene Detail Information
