Gene Name	CDH4
Gene ID	1002
Gene Full Name	cadherin 4
Gene Alias	CAD4|R-CAD|RCAD
Transcripts	ENSG00000179242
Virus	HPV
Gene Type	protein-coding
HPA Location Info	Plasma membrane;
Membrane Info	Predicted membrane proteins
Uniport_ID	P55283
HGNC ID	HGNC:1763
OMIM ID	603006
Summary	This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
5003042	chr20	2	2	2	6	View
5003191	chr20	1	2	2	5	View
5003344	chr20	4	0	0	4	View
5003546	chr20	3	0	0	3	View
5003547	chr20	2	0	1	3	View
5003548	chr20	2	0	1	3	View
5003549	chr20	2	0	1	3	View
5003550	chr20	2	0	1	3	View
5003576	chr20	2	0	1	3	View
5003834	chr20	2	0	0	2	View
5003835	chr20	2	0	0	2	View
5003836	chr20	2	0	0	2	View
5004765	chr20	3	4	1	8	View
5010335	chr20	22	28	0	50	View
5010360	chr20	74	205	1	280	View
5011852	chr20	4	12	0	16	View
5015694	chr20	2	0	1	3	View
5015695	chr20	2	0	2	4	View

Data ID	Experiment type	Sample number	Platform
C   GSE183048	Chip-seq	24	Illumina HiSeq 4000 (Homo sapiens)
GSE169622	Methylation profiling (Array)	9	Infinium MethylationEPIC
GSE65858	Expression array	270	Illumina HumanHT-12 V4.0 expression beadchip
GSE181805	Expression array	25	[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
GSE196215	RNA-seq	8	Illumina NovaSeq 6000 (Homo sapiens)
GSE140662	Expression array	8	[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
GSE55542	Expression array	36	Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
C   GSE143026	ATAC-seq;Chip-seq;RNA-seq	30	Illumina HiSeq 2500 (Homo sapiens)
TCGA_CESC	DNA methylation sequencing;RNA-seq	288	TCGA
GSE51993	Expression array	48	Illumina Human v2 MicroRNA expression beadchip;Illumina HumanHT-12 V4.0 expression beadchip
GSE55550	Expression array	155	Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
GSE165883	RNA-seq	20	Illumina NextSeq 500 (Homo sapiens)

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE183048 - CDH4 peak across samples

Peak Plot

> Dataset: GSE143026 - CDH4 peak across samples

Peak Plot