Gene Information
|
Gene Name
|
EIF4EBP1 |
|
Gene ID
|
1978
|
|
Gene Full Name
|
eukaryotic translation initiation factor 4E binding protein 1 |
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Gene Alias
|
4E-BP1|4EBP1|BP-1|PHAS-I |
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Transcripts
|
ENSG00000187840
|
|
Virus
|
MCV |
|
Gene Type
|
protein-coding |
|
HPA Location Info
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Nucleoplasm, Cytosol; 
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Membrane Info
|
Cancer-related genes, Predicted intracellular proteins |
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Uniport_ID
|
Q13541
|
|
HGNC ID
|
HGNC:3288
|
|
OMIM ID
|
602223 |
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Summary
|
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008] |
Target gene [EIF4EBP1] related to virus gene/protein/region 
Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section
Target gene [EIF4EBP1] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
C GSE147406
|
Chip-seq |
39 |
Illumina NextSeq 500 (Homo sapiens) |
|
C GSE124856
|
Chip-seq |
8 |
Illumina NextSeq 500 (Homo sapiens) |
|
GSE136867
|
scRNA-seq |
2 |
Illumina NextSeq 500 (Homo sapiens) |
|
GSE226438
|
scRNA-seq |
11 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
S GSE117988
|
scRNA-seq |
6 |
Illumina HiSeq 2500 (Homo sapiens) |
|
C GSE69877
|
Chip-seq |
10 |
Illumina HiSeq 2000 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens) |
|
C GSE230758
|
Chip-seq |
20 |
Illumina HiSeq 2500 (Homo sapiens) |
|
S GSE118056
|
scRNA-seq |
4 |
Illumina NovaSeq 6000 (Homo sapiens) |
When the query gene is differentially changed in the dataset, a feature/violin plot will be displayed.
> Dataset: GSE117988 - Gene expression in cell subsets
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> Dataset: GSE118056 - Gene expression in cell subsets
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MCV Target gene Detail Information
