Gene Name	ESR2
Gene ID	2100
Gene Full Name	estrogen receptor 2
Gene Alias	ER-BETA|ESR-BETA|ESRB|ESTRB|Erb|NR3A2|ODG8
Transcripts	ENSG00000140009
Virus	HPV
Gene Type	protein-coding
HPA Location Info	Nucleoplasm;Vesicles;
Membrane Info	Cancer-related genes, Disease related genes, FDA approved drug targets, Human disease related genes, Nuclear receptors, Predicted intracellular proteins, Transcription factors
Uniport_ID	Q92731
HGNC ID	HGNC:3468
OMIM ID	601663
Summary	This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	32677948	A7376G	LCR		Squamous Intraepithelial Lesions Cervical Intraepithelial Neoplasia	G L T	View
2	32677948	T7791A	LCR		Squamous Intraepithelial Lesions Cervical Intraepithelial Neoplasia	G L T	View
3	32677948	A7793C	LCR		Squamous Intraepithelial Lesions Cervical Intraepithelial Neoplasia	G L T	View
4	32677948	C7265G	LCR		Squamous Intraepithelial Lesions Cervical Intraepithelial Neoplasia	G L T	View
5	29695285	A7793G	LCR		Papillomavirus Infections	G R S L T	View

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
5015004	chr14	1	16	1	18	View

Data ID	Experiment type	Sample number	Platform
C   GSE183048	Chip-seq	24	Illumina HiSeq 4000 (Homo sapiens)
GSE169622	Methylation profiling (Array)	9	Infinium MethylationEPIC
GSE65858	Expression array	270	Illumina HumanHT-12 V4.0 expression beadchip
GSE181805	Expression array	25	[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
GSE196215	RNA-seq	8	Illumina NovaSeq 6000 (Homo sapiens)
GSE140662	Expression array	8	[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
GSE55542	Expression array	36	Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
C   GSE143026	ATAC-seq;Chip-seq;RNA-seq	30	Illumina HiSeq 2500 (Homo sapiens)
TCGA_CESC	DNA methylation sequencing;RNA-seq	288	TCGA
GSE51993	Expression array	48	Illumina Human v2 MicroRNA expression beadchip;Illumina HumanHT-12 V4.0 expression beadchip
GSE55550	Expression array	155	Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
GSE165883	RNA-seq	20	Illumina NextSeq 500 (Homo sapiens)

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE183048 - ESR2 peak across samples

Peak Plot

> Dataset: GSE143026 - ESR2 peak across samples

Peak Plot