Gene Name	FHIT
Gene ID	2272
Gene Full Name	fragile histidine triad diadenosine triphosphatase
Gene Alias	AP3Aase|FRA3B
Transcripts	ENSG00000189283
Virus	HPV
Gene Type	protein-coding
HPA Location Info	Nucleoli fibrillar center, Plasma membrane;
Membrane Info	Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Uniport_ID	P49789
HGNC ID	HGNC:3701
OMIM ID	601153
Summary	The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage. [provided by RefSeq, Aug 2017]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
5000047	chr3	3732	484	178	4394	View
5000049	chr3	3705	441	164	4310	View
5000060	chr3	3461	368	123	3952	View
5000068	chr3	3093	320	103	3516	View
5000276	chr3	111	72	197	380	View
5000295	chr3	107	63	179	349	View
5000385	chr3	78	39	129	246	View
5000450	chr3	83	25	86	194	View
5000464	chr3	82	23	76	181	View
5000490	chr3	88	21	56	165	View
5000504	chr3	88	20	50	158	View
5000779	chr3	5	10	70	85	View
5000810	chr3	61	11	9	81	View
5000830	chr3	59	11	8	78	View
5000854	chr3	57	10	8	75	View
5000873	chr3	57	9	8	74	View
5000879	chr3	57	9	8	74	View
5000895	chr3	10	49	11	70	View
5000912	chr3	10	48	10	68	View
5000914	chr3	52	9	7	68	View
5000915	chr3	52	9	7	68	View
5000917	chr3	52	9	7	68	View
5000968	chr3	48	10	5	63	View
5000969	chr3	48	10	5	63	View
5001006	chr3	32	4	23	59	View
5001067	chr3	40	10	4	54	View
5001071	chr3	40	10	4	54	View
5001072	chr3	40	10	4	54	View
5001073	chr3	40	10	4	54	View
5001074	chr3	40	10	4	54	View
5001075	chr3	40	10	4	54	View
5001123	chr3	7	36	7	50	View
5001152	chr3	25	3	19	47	View
5001172	chr3	37	6	3	46	View
5001175	chr3	37	6	3	46	View
5001177	chr3	37	6	3	46	View
5001178	chr3	37	6	3	46	View
5001179	chr3	37	6	3	46	View
5001209	chr3	22	3	18	43	View
5001256	chr3	35	5	1	41	View
5001261	chr3	35	5	1	41	View
5001346	chr3	15	3	19	37	View
5001350	chr3	6	30	1	37	View
5001440	chr3	29	4	1	34	View
5001451	chr3	5	27	1	33	View
5002181	chr3	4	10	0	14	View
5002394	chr3	12	0	0	12	View
5002431	chr3	4	7	0	11	View
5002697	chr3	0	8	0	8	View
5002915	chr3	4	1	2	7	View
5003907	chr3	0	1	0	1	View
5003908	chr3	1	0	0	1	View
5004200	chr3	1	0	0	1	View
5004239	chr3	1	0	0	1	View
5006674	chr3	0	1	0	1	View
5006795	chr3	66	6	3	75	View
5006796	chr3	10	3	4	17	View
5006797	chr3	1	2	0	3	View
5006798	chr3	86	4	2	92	View
5006799	chr3	0	0	0	0	View
5007482	chr3	11	3	0	14	View
5007483	chr3	3	1	3	7	View
5013416	chr3	3	2	2	7	View
5013417	chr3	3	2	0	5	View
5013418	chr3	15	7	1	23	View
5013419	chr3	15	7	1	23	View
5013420	chr3	6	4	1	11	View
5013421	chr3	6	4	1	11	View
5015787	chr3	180	7	0	187	View
5015788	chr3	13	1	0	14	View
5015789	chr3	5	1	0	6	View
5015790	chr3	2	0	0	2	View
5015791	chr3	47	15	2	64	View
5015792	chr3	2	1	0	3	View
5015793	chr3	0	10	1	11	View
5015794	chr3	1	2	0	3	View
5015795	chr3	11	0	0	11	View
5015796	chr3	12	6	0	18	View
5015797	chr3	8	1	0	9	View
5015798	chr3	1	8	0	9	View
5015799	chr3	150	34	61	245	View
5015800	chr3	62	16	6	84	View
5015801	chr3	56	10	5	71	View
5015802	chr3	16	49	21	86	View
5015803	chr3	3	1	6	10	View
5015804	chr3	0	0	0	0	View
5015805	chr3	36	5	1	42	View
5015806	chr3	61	6	28	95	View
5015807	chr3	57	6	28	91	View
5015808	chr3	1	0	0	1	View
5015809	chr3	4048	667	182	4897	View

Data ID	Experiment type	Sample number	Platform
C   GSE183048	Chip-seq	24	Illumina HiSeq 4000 (Homo sapiens)
GSE139324	scRNA-seq	63	Illumina NextSeq 500 (Homo sapiens)
GSE169622	Methylation profiling (Array)	9	Infinium MethylationEPIC
GSE65858	Expression array	270	Illumina HumanHT-12 V4.0 expression beadchip
GSE181805	Expression array	25	[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
GSE196215	RNA-seq	8	Illumina NovaSeq 6000 (Homo sapiens)
GSE164690	scRNA-seq	51	Illumina NextSeq 500 (Homo sapiens)
GSE138080	Expression array	35	Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version)
GSE140662	Expression array	8	[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
GSE55542	Expression array	36	Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
C   GSE143026	ATAC-seq;Chip-seq;RNA-seq	30	Illumina HiSeq 2500 (Homo sapiens)
E   TCGA_CESC	DNA methylation sequencing;RNA-seq	288	TCGA
GSE51993	Expression array	48	Illumina Human v2 MicroRNA expression beadchip;Illumina HumanHT-12 V4.0 expression beadchip
GSE55550	Expression array	155	Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
GSE165883	RNA-seq	20	Illumina NextSeq 500 (Homo sapiens)

• Expression profiling
• Genome binding/occupancy profiling

When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.

> Dataset: TCGA_CESC - FHIT expression across samples

Volcano Plot

Bar Plot