Gene Name	HIF1A
Gene ID	3091
Gene Full Name	hypoxia inducible factor 1 subunit alpha
Gene Alias	HIF-1-alpha|HIF-1A|HIF-1alpha|HIF1|HIF1-ALPHA|MOP1|PASD8|bHLHe78
Transcripts	ENSG00000100644
Virus	HBV
Gene Type	protein-coding
HPA Location Info	Nucleoplasm, Nuclear bodies;
Membrane Info	Cancer-related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transcription factors
Uniport_ID	Q16665
HGNC ID	HGNC:4910
OMIM ID	603348
Summary	This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	24346287	K130M	X	X	Carcinoma, Hepatocellular	T	View
2	24346287	V131I	X	X	Carcinoma, Hepatocellular	T	View
3	24346287	A1630G	X	X	Carcinoma, Hepatocellular	T	View
4	24346287	A1762T	X	X	Carcinoma, Hepatocellular	T	View
5	24346287	G1721A	X	X	Carcinoma, Hepatocellular	T	View
6	24346287	G1764A	X	X	Carcinoma, Hepatocellular	T	View
7	24346287	A12T	X	X	Carcinoma, Hepatocellular	T	View
8	24346287	A66T	X	X	Carcinoma, Hepatocellular	T	View
9	24346287	E109D	X	X	Carcinoma, Hepatocellular	T	View
10	24346287	H86Y	X	X	Carcinoma, Hepatocellular	T	View
11	25019072	K130M	X	X	Carcinoma, Hepatocellular	T	View
12	25019072	V131I	X	X	Carcinoma, Hepatocellular	T	View
13	32887289	W196X	S	S		T	View
14	32887289	M204I	RT	P		T	View

Data ID	Experiment type	Sample number	Platform
S   GSE252863	scRNA-seq	10	Illumina HiSeq 2500 (Homo sapiens)
GSE236281	RNA-seq	12	Illumina MiSeq (Homo sapiens)
GSE199850	scRNA-seq	1	HiSeq X Ten (Homo sapiens)
C   GSE68402	Chip-seq	26	Illumina MiSeq (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens)
S   GSE247322	scRNA-seq	27	Illumina NovaSeq 6000 (Homo sapiens)
TCGA_LIHC_HBV	DNA methylation sequencing;RNA-seq	97	TCGA
C   GSE270130	Chip-seq	27	Illumina NovaSeq 6000 (Homo sapiens)
GSE224901	RNA-seq	21	Illumina NovaSeq 6000 (Homo sapiens)
GSE100400	Chip-seq;RNA-seq;4C_cccDNA	31	Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (Mus musculus)
GSE173897	RNA-seq	95	Illumina HiSeq 4000 (Homo sapiens)
GSE262515	RNA-seq	21	Illumina HiSeq 2500 (Homo sapiens);Illumina HiSeq 2500 (Mus musculus)
GSE110345	RNA-seq	4	Illumina HiSeq 2500 (Homo sapiens)
C   GSE131257	ATAC-seq;RNA-seq	19	Illumina HiSeq 2500 (Homo sapiens)
GSE94660	RNA-seq	42	Illumina HiSeq 2500 (Homo sapiens)

• scRNA data
• Genome binding/occupancy profiling

When the query gene is differentially changed in the dataset, a feature/violin plot will be displayed.

> Dataset: GSE252863 - Gene expression in cell subsets
> Dataset: GSE247322 - Gene expression in cell subsets