Gene Name	NKX2-2
Gene ID	4821
Gene Full Name	NK2 homeobox 2
Gene Alias	NKX2.2|NKX2B
Transcripts	ENSG00000125820
Virus	HPV
Gene Type	protein-coding
HPA Location Info
Membrane Info	Predicted intracellular proteins, Transcription factors
Uniport_ID	O95096
HGNC ID	HGNC:7835
OMIM ID	604612
Summary	The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor. [provided by RefSeq, Jul 2008]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
5013316	chr20	341	64	30	435	View
5013317	chr20	125	16	1	142	View
5013318	chr20	71	7	1	79	View
5013319	chr20	240	151	53	444	View
5013320	chr20	237	154	51	442	View
5013321	chr20	232	171	54	457	View

Data ID	Experiment type	Sample number	Platform
M   GSE169622	Methylation profiling (Array)	9	Infinium MethylationEPIC
GSE65858	Expression array	270	Illumina HumanHT-12 V4.0 expression beadchip
GSE181805	Expression array	25	[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
GSE196215	RNA-seq	8	Illumina NovaSeq 6000 (Homo sapiens)
GSE140662	Expression array	8	[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
GSE55542	Expression array	36	Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
GSE143026	ATAC-seq;Chip-seq;RNA-seq	30	Illumina HiSeq 2500 (Homo sapiens)
M   TCGA_CESC	DNA methylation sequencing;RNA-seq	288	TCGA
GSE51993	Expression array	48	Illumina Human v2 MicroRNA expression beadchip;Illumina HumanHT-12 V4.0 expression beadchip
GSE55550	Expression array	155	Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
GSE165883	RNA-seq	20	Illumina NextSeq 500 (Homo sapiens)

• Methylation profiling

When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.

> Dataset: GSE169622 - NKX2-2 methylation across samples

Volcano Plot (delta beta value > 0.2 & FDR < 0.05)

Bar Plot (delta beta value > 0.2)

> Dataset: TCGA_CESC - NKX2-2 methylation across samples

Volcano Plot (delta beta value > 0.2 & FDR < 0.05)

Bar Plot (delta beta value > 0.2)