Gene Name	NRXN1
Gene ID	9378
Gene Full Name	neurexin 1
Gene Alias	Hs.22998|PTHSL2|SCZD17
Transcripts	ENSG00000179915
Virus	HPV
Gene Type	protein-coding
HPA Location Info	Plasma membrane;Intracellular and membrane;
Membrane Info	Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Uniport_ID	P58400, Q9ULB1
HGNC ID	HGNC:8008
OMIM ID	600565
Summary	This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca(2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3,000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for this gene in the 3' region. Mutations in this gene are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia. [provided by RefSeq, Aug 2016]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
5009227	chr2	0	3	0	3	View
5010136	chr2	1	0	0	1	View
5010137	chr2	5	1	0	6	View
5011194	chr2	0	0	0	0	View
5015437	chr2	56	36	2	94	View
5015438	chr2	15	1	28	44	View
5015439	chr2	46	7	10	63	View
5015440	chr2	39	2	2	43	View
5015441	chr2	0	1	0	1	View
5015442	chr2	0	0	0	0	View
5015443	chr2	2	0	0	2	View
5015444	chr2	0	0	0	0	View
5015445	chr2	4	0	0	4	View
5015446	chr2	47	289	37	373	View
5015447	chr2	10	1	1	12	View
5015448	chr2	2	1	0	3	View
5015449	chr2	3	2	8	13	View
5015450	chr2	16	3	0	19	View
5015451	chr2	0	0	0	0	View
5015452	chr2	0	0	0	0	View
5015453	chr2	2	1	1	4	View
5015454	chr2	3	3	4	10	View
5015455	chr2	7	5	1	13	View
5015456	chr2	0	8	0	8	View
5015457	chr2	1	0	1	2	View
5015458	chr2	2	2	0	4	View
5015459	chr2	2	1	0	3	View
5015460	chr2	0	1	0	1	View
5015461	chr2	1	2	0	3	View
5015462	chr2	31	2	0	33	View
5015463	chr2	0	0	0	0	View
5015464	chr2	2	1	1	4	View
5015465	chr2	26	10	37	73	View
5015466	chr2	1	0	0	1	View
5017284	chr2	0	0	0	0	View
5017285	chr2	1	0	0	1	View
5017286	chr2	6	6	14	26	View
5017287	chr2	6	5	12	23	View
5017288	chr2	1	0	1	2	View

Data ID	Experiment type	Sample number	Platform
C   GSE183048	Chip-seq	24	Illumina HiSeq 4000 (Homo sapiens)
GSE169622	Methylation profiling (Array)	9	Infinium MethylationEPIC
GSE65858	Expression array	270	Illumina HumanHT-12 V4.0 expression beadchip
GSE181805	Expression array	25	[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
GSE196215	RNA-seq	8	Illumina NovaSeq 6000 (Homo sapiens)
GSE140662	Expression array	8	[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
GSE55542	Expression array	36	Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
C   GSE143026	ATAC-seq;Chip-seq;RNA-seq	30	Illumina HiSeq 2500 (Homo sapiens)
M   TCGA_CESC	DNA methylation sequencing;RNA-seq	288	TCGA
GSE51993	Expression array	48	Illumina Human v2 MicroRNA expression beadchip;Illumina HumanHT-12 V4.0 expression beadchip
GSE55550	Expression array	155	Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
GSE165883	RNA-seq	20	Illumina NextSeq 500 (Homo sapiens)

• Methylation profiling
• Genome binding/occupancy profiling

When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.

> Dataset: GSE183048 - NRXN1 peak across samples

Peak Plot

> Dataset: GSE143026 - NRXN1 peak across samples

Peak Plot