HPV Target gene Detail Information

> OTULIN Gene Search Result


Gene Information
Gene Name OTULIN
Gene ID 90268
Gene Full Name OTU deubiquitinase with linear linkage specificity
Gene Alias AIPDS|AIPDSA|FAM105B|GUM|IMD107
Transcripts ENSG00000154124
Virus HPV
Gene Type protein-coding
HPA Location Info Mitochondria;Plasma membrane;
Membrane Info Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins
Uniport_ID Q96BN8
HGNC ID HGNC:25118
OMIM ID 615712
Summary This gene encodes a member of the peptidase C65 family of ubiquitin isopeptidases. Members of this family remove ubiquitin from proteins. The encoded enzyme specifically recognizes and removes M1(Met1)-linked, or linear, ubiquitin chains from protein substrates. Linear ubiquitin chains are known to regulate the NF-kappa B signaling pathway in the context of immunity and inflammation. Mutations in this gene cause a potentially fatal autoinflammatory syndrome in human patients. [provided by RefSeq, Sep 2016]
Target gene [OTULIN] related to VISs

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section


DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
5002135 chr5 15 0 0 15 View
5011563 chr5 4 2 0 6 View

Target gene [OTULIN] related to Omics data
Data ID Experiment type Sample number Platform
C
  GSE183048 		Chip-seq 24 Illumina HiSeq 4000 (Homo sapiens)
GSE226620 scRNA-seq 30 HiSeq X Ten (Homo sapiens)
GSE139324 scRNA-seq 63 Illumina NextSeq 500 (Homo sapiens)
GSE169622 Methylation profiling (Array) 9 Infinium MethylationEPIC
GSE65858 Expression array 270 Illumina HumanHT-12 V4.0 expression beadchip
GSE181805 Expression array 25 [HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
GSE196215 RNA-seq 8 Illumina NovaSeq 6000 (Homo sapiens)
GSE138080 Expression array 35 Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version)
GSE140662 Expression array 8 [HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
C
  GSE143026 		ATAC-seq;Chip-seq;RNA-seq 30 Illumina HiSeq 2500 (Homo sapiens)
TCGA_CESC DNA methylation sequencing;RNA-seq 288 TCGA
GSE51993 Expression array 48 Illumina Human v2 MicroRNA expression beadchip;Illumina HumanHT-12 V4.0 expression beadchip
GSE165883 RNA-seq 20 Illumina NextSeq 500 (Homo sapiens)


When the gene can detect a peak in the dataset, a peak plot will be displayed.


> Dataset: GSE183048 - OTULIN peak across samples

Peak Plot

> Dataset: GSE143026 - OTULIN peak across samples

Peak Plot