Gene Name	PCMT1
Gene ID	5110
Gene Full Name	protein-L-isoaspartate (D-aspartate) O-methyltransferase
Gene Alias	PIMT
Transcripts	ENSG00000120265
Virus	HBV
Gene Type	protein-coding
HPA Location Info	Cytosol;
Membrane Info	Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	P22061
HGNC ID	HGNC:8728
OMIM ID	176851
Summary	This gene encodes a member of the type II class of protein carboxyl methyltransferase enzymes. The encoded enzyme plays a role in protein repair by recognizing and converting D-aspartyl and L-isoaspartyl residues resulting from spontaneous deamidation back to the normal L-aspartyl form. The encoded protein may play a protective role in the pathogenesis of Alzheimer's disease, and single nucleotide polymorphisms in this gene have been associated with spina bifida and premature ovarian failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1003259	chr6	86	43	22	151	View
1040510	chr6	11	5	0	16	View
1040511	chr6	11	5	0	16	View
1040512	chr6	10	4	0	14	View
1040513	chr6	10	3	0	13	View
1040514	chr6	10	3	0	13	View
1040515	chr6	9	3	0	12	View
1040516	chr6	9	2	0	11	View
1040517	chr6	9	2	0	11	View
1040518	chr6	8	1	0	9	View
1040519	chr6	8	1	0	9	View
1040520	chr6	7	1	0	8	View
1040521	chr6	6	1	0	7	View
1040522	chr6	6	1	0	7	View

Data ID	Experiment type	Sample number	Platform
GSE252863	scRNA-seq	10	Illumina HiSeq 2500 (Homo sapiens)
GSE236281	RNA-seq	12	Illumina MiSeq (Homo sapiens)
C   GSE35465	Chip-seq;RNA-seq	6	Illumina HiSeq 2000 (Homo sapiens)
GSE199850	scRNA-seq	1	HiSeq X Ten (Homo sapiens)
C   GSE68402	Chip-seq	26	Illumina MiSeq (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens)
GSE247322	scRNA-seq	27	Illumina NovaSeq 6000 (Homo sapiens)
TCGA_LIHC_HBV	DNA methylation sequencing;RNA-seq	97	TCGA
C   GSE270130	Chip-seq	27	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE64877	Chip-seq	2	Illumina Genome Analyzer (Homo sapiens)
GSE224901	RNA-seq	21	Illumina NovaSeq 6000 (Homo sapiens)
GSE100400	Chip-seq;RNA-seq;4C_cccDNA	31	Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (Mus musculus)
GSE173897	RNA-seq	95	Illumina HiSeq 4000 (Homo sapiens)
GSE262515	RNA-seq	21	Illumina HiSeq 2500 (Homo sapiens);Illumina HiSeq 2500 (Mus musculus)
GSE110345	RNA-seq	4	Illumina HiSeq 2500 (Homo sapiens)
C   GSE131257	ATAC-seq;RNA-seq	19	Illumina HiSeq 2500 (Homo sapiens)
GSE94660	RNA-seq	42	Illumina HiSeq 2500 (Homo sapiens)

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE35465 - PCMT1 peak across samples

Peak Plot

> Dataset: GSE68402 - PCMT1 peak across samples

Peak Plot

> Dataset: GSE270130 - PCMT1 peak across samples

Peak Plot

> Dataset: GSE64877 - PCMT1 peak across samples

Peak Plot

> Dataset: GSE131257 - PCMT1 peak across samples

Peak Plot