Gene Name	SRY
Gene ID	6736
Gene Full Name	sex determining region Y
Gene Alias	SRXX1|SRXY1|TDF|TDY
Transcripts	ENSG00000184895
Virus	HPV
Gene Type	protein-coding
HPA Location Info
Membrane Info	Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors
Uniport_ID	Q05066
HGNC ID	HGNC:11311
OMIM ID	480000
Summary	This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome); translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome. [provided by RefSeq, Jul 2008]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	29695285	A7540G	LCR		Papillomavirus Infections	G R S L T	View
2	24099556	G7553T	LCR		Cervical Intraepithelial Neoplasia Uterine Cervical Neoplasms	G R C L T	View
3	24099556	A7339T	LCR		Cervical Intraepithelial Neoplasia Uterine Cervical Neoplasms	G R C L T	View
4	24099556	C7930T	LCR		Cervical Intraepithelial Neoplasia Uterine Cervical Neoplasms	G R C L T	View
5	24099556	G7193T	LCR		Cervical Intraepithelial Neoplasia Uterine Cervical Neoplasms	G R C L T	View
6	24099556	T7201C	LCR		Cervical Intraepithelial Neoplasia Uterine Cervical Neoplasms	G R C L T	View
7	28767682	A7830C	LCR		Uterine Cervical Neoplasms	G R S L T	View
8	28767682	G7826A	LCR		Uterine Cervical Neoplasms	G R S L T	View
9	28767682	A7900C	LCR		Uterine Cervical Neoplasms	G R S L T	View
10	28767682	C7310T	LCR		Uterine Cervical Neoplasms	G R S L T	View

Data ID	Experiment type	Sample number	Platform
GSE65858	Expression array	270	Illumina HumanHT-12 V4.0 expression beadchip
GSE181805	Expression array	25	[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
GSE196215	RNA-seq	8	Illumina NovaSeq 6000 (Homo sapiens)
GSE140662	Expression array	8	[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
GSE55542	Expression array	36	Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
C   GSE143026	ATAC-seq;Chip-seq;RNA-seq	30	Illumina HiSeq 2500 (Homo sapiens)
GSE51993	Expression array	48	Illumina Human v2 MicroRNA expression beadchip;Illumina HumanHT-12 V4.0 expression beadchip
GSE55550	Expression array	155	Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
GSE165883	RNA-seq	20	Illumina NextSeq 500 (Homo sapiens)

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE143026 - SRY peak across samples

Peak Plot