All Curated Mutation Sites in SARS-CoV-2 
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 The Virus Mutation(VM) module provides researchers the annotations of reported pathogenic mutations in SARS-CoV-2 related to human diseases. The curated VM information includes mutation site, mutation level, virus gene/protein/region, virus-associated disease, genotype/subtype, literature evidence, etc.


Browse Data by Virus Gene/Protein/Region, Disease OR Description
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For highly variable viruses (e.g., HBV, HIV, SARS-CoV-2), ViMIC defaults to displaying mutations in a specific region. Click the green button to search for other regions, or click "Show All" to view all mutations (loading speed may be affected by network conditions).

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ORF1a
  
ORF1b
  
ORF3a
  
3CLpro
  
3'UTR
  
5'UTR
  
RBD
  
ORF7b-ORF8
  
upstream of N
  
Furin cleavage site
  
E
  
endoRNase
  
Exonuclease
  
S
  
NSP13
  
NSP3
  
M
  
Mpro
  
Methyltransferase
  
N
  
NSP14
  
NSP12
  
Non-coding region
  
NP
  
NS3
  
NS7a
  
NS7b
  
NS8
  
NSP5
  
NSP1
  
NSP10
  
NSP11
  
NSP15
  
NSP16
  
NSP2
  
NSP4
  
NSP6
  
NSP7
  
NSP8
  
NSP9
  
NTD
  
ORF8
  
ORF1ab
  
ORF9b
  
ORF10
  
ORF3
  
ORF6
  
ORF7a
  
ORF7b
  
ORF9
  
ORF9c
  
PLpro
  
RdRp
  
RBM
  
Replicase
  
RNA primase
  

Keyword: COVID-19-34634791
ID PMID Mutation Gene/Protein/Region Encoding Gene/Protein Disease Description Detail
1 34634791 S171L
ORF3a
ORF3a
COVID-19
G
R
S
View
2 34634791 V82A
ORF7a
ORF7a
COVID-19
G
R
S
View
3 34634791 A3209V
ORF1a
ORF1a
COVID-19
G
R
S
View
4 34634791 L452R
S
S
COVID-19
G
R
S
I
View
5 34634791 T60A
ORF9b
ORF9b
COVID-19
G
R
S
View
6 34634791 S26L
ORF3a
ORF3a
COVID-19
G
R
S
View
7 34634791 V3718A
ORF1a
ORF1a
COVID-19
G
R
S
View
8 34634791 I82T
M
M
COVID-19
G
R
S
View
9 34634791 V62F
E
E
COVID-19
G
R
S
View
10 34634791 N43Y
ORF7a
ORF7a
COVID-19
G
R
S
View
11 34634791 I82S
M
M
COVID-19
G
R
S
View
12 34634791 E484K
S
S
COVID-19
G
R
S
I
View
13 34634791 L116F
ORF7a
ORF7a
COVID-19
G
R
S
View
14 34634791 Q57H
ORF3a
ORF3a
COVID-19
G
R
S
View
15 34634791 P314L
ORF1b
ORF1b
COVID-19
G
R
S
View
16 34634791 P10S
ORF9b
ORF9b
COVID-19
G
R
S
View
17 34634791 T83I
ORF9b
ORF9b
COVID-19
G
R
S
View
18 34634791 T11I
ORF8
ORF8
COVID-19
G
R
S
View
19 34634791 P34S
ORF7a
ORF7a
COVID-19
G
R
S
View
20 34634791 Q1011H
ORF1b
ORF1b
COVID-19
G
R
S
View
21 34634791 P3359S
ORF1a
ORF1a
COVID-19
G
R
S
View
22 34634791 A105S
ORF7a
ORF7a
COVID-19
G
R
S
View
23 34634791 S92L
ORF3a
ORF3a
COVID-19
G
R
S
View
24 34634791 P314F
ORF1b
ORF1b
COVID-19
G
R
S
View
25 34634791 L21F
E
E
COVID-19
G
R
S
View
26 34634791 N501T
S
S
COVID-19
G
R
S
I
View
27 34634791 G639V
S
S
COVID-19
G
R
S
View
28 34634791 S206F
N
N
COVID-19
G
R
S
View
29 34634791 V100L
ORF8
ORF8
COVID-19
G
R
S
View
30 34634791 T205I
N
N
COVID-19
G
R
S
View
31 34634791 I121L
ORF8
ORF8
COVID-19
G
R
S
View
32 34634791 R115L
ORF8
ORF8
COVID-19
G
R
S
View
33 34634791 T4065I
ORF1a
ORF1a
COVID-19
G
R
S
View
34 34634791 P71L
E
E
COVID-19
G
R
S
View
35 34634791 N501Y
S
S
COVID-19
G
R
S
I
View
36 34634791 Y73C
ORF8
ORF8
COVID-19
G
R
S
View
37 34634791 E106D
ORF8
ORF8
COVID-19
G
R
S
View
38 34634791 E92K
ORF7a
ORF7a
COVID-19
G
R
S
View
39 34634791 Q77E
ORF9b
ORF9b
COVID-19
G
R
S
View
40 34634791 L84S
ORF8
ORF8
COVID-19
G
R
S
View
Contents
Description

The table shows all curated mutation sites of SARS-CoV-2 in each literature

Table Description Column Note
D
The study mentioned a certain treatment method, such as drug resistance caused by mutations.
G
The study mentioned the virus genotype/subtype information.
R
The study mentioned the reference sequence used for comparison, or the original strain of the virus used for site-directed mutagenesis.
S
The study provided sequence information or accession numbers.
L
The study provided the geographic region/country of data origin.
C
The study provided clinical baseline information.
I
The study involved information related to immune.
T
The study involved host target genes.