All Curated Mutation Sites in DENV 
Back to Mutation Home

 The Virus Mutation(VM) module provides researchers the annotations of reported pathogenic mutations in DENV related to human diseases. The curated VM information includes mutation site, mutation level, virus gene/protein/region, virus-associated disease, genotype/subtype, literature evidence, etc.


Browse Data by Virus Gene/Protein/Region, Disease OR Description
*Please select one option you are interested in, the page will be automatically redirected.
     
     

Click the button below to quickly view the viral genes/regions/protein for mutation

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C
  
E
  
NS1
  
NS2A
  
NS2B
  
NS3
  
NS4A
  
NS4B
  
NS5
  
prM
  

ID PMID Mutation Gene/Protein/Region Encoding Gene/Protein Disease Description Detail
1 28767984 I101T
C
Capsid
Dengue
G
R
S
L
View
2 28767984 C4279T
NS2B
NS2B
Dengue
G
R
S
L
View
3 28767984 V49A
NS2B
NS2B
Dengue
G
R
S
L
View
4 28767984 V534V
NS3
NS3
Dengue
G
R
S
L
View
5 28767984 I810M
NS5
NS5
Dengue
G
R
S
L
View
6 29998087 G1612A
E
Envelope
Dengue
G
R
S
C
L
View
7 29998087 T1606C
E
Envelope
Dengue
G
R
S
C
L
View
8 29998087 T2710C
NS5
NS5
Dengue
G
R
S
C
L
View
9 23360780 M108I
C
Capsid
Dengue
G
R
S
L
View
10 23360780 T112A
C
Capsid
Dengue
G
R
S
L
View
11 23360780 I81A
E
Envelope
Dengue
G
R
S
L
View
12 23360780 I81V
E
Envelope
Dengue
G
R
S
L
View
13 23360780 S124P
E
Envelope
Dengue
G
R
S
L
View
14 23360780 H132Y
E
Envelope
Dengue
G
R
S
L
View
15 23360780 S164P
E
Envelope
Dengue
G
R
S
L
View
16 23360780 A169T
E
Envelope
Dengue
G
R
S
L
View
17 23360780 K225E
E
Envelope
Dengue
G
R
S
L
View
18 23360780 T270N
E
Envelope
Dengue
G
R
S
L
View
19 23360780 K281E
E
Envelope
Dengue
G
R
S
L
View
20 23360780 L291T
E
Envelope
Dengue
G
R
S
L
View
21 23360780 T219A
E
Envelope
Dengue
G
R
S
L
View
22 30528395 I440T
E
Envelope
Dengue
G
R
S
C
L
View
23 34676175 I161T
E
Envelope
Dengue
G
R
L
View
24 34676175 L402F
E
Envelope
Dengue
G
R
L
View
25 34676175 A88T
E
Envelope
Dengue
G
R
L
View
26 34676175 F96L
E
Envelope
Dengue
G
R
L
View
27 34676175 M297V
E
Envelope
Dengue
G
R
L
View
28 34676175 T339S
E
Envelope
Dengue
G
R
L
View
29 34676175 I378L
E
Envelope
Dengue
G
R
L
View
30 34676175 V436I
E
Envelope
Dengue
G
R
L
View
31 34676175 V312L
E
Envelope
Dengue
G
R
L
View
32 34676175 V380I
E
Envelope
Dengue
G
R
L
View
33 30192396 M104V
prM
prM
Dengue
G
R
S
C
L
View
34 30192396 V112A
prM
prM
Dengue
G
R
S
C
L
View
35 30192396 K166N
prM
prM
Dengue
G
R
S
C
L
View
36 30192396 F169L
prM
prM
Dengue
G
R
S
C
L
View
37 30192396 V51G
prM
prM
Dengue
G
R
S
C
L
View
38 30192396 L54F
prM
prM
Dengue
G
R
S
C
L
View
39 30192396 R55C
prM
prM
Dengue
G
R
S
C
L
View
40 37879150 I114L
E
Envelope
Dengue
G
R
C
L
View
41 37879150 I293T
E
Envelope
Dengue
G
R
C
L
View
42 37879150 K203E
E
Envelope
Dengue
G
R
C
L
View
43 37879150 T88A
E
Envelope
Dengue
G
R
C
L
View
44 37879150 T19I
E
Envelope
Dengue
G
R
C
L
View
45 37879150 D37N
E
Envelope
Dengue
G
R
C
L
View
46 37879150 G100A
E
Envelope
Dengue
G
R
C
L
View
47 37879150 W101G
E
Envelope
Dengue
G
R
C
L
View
48 37879150 102delG
E
Envelope
Dengue
G
R
C
L
View
49 37879150 136delK
E
Envelope
Dengue
G
R
C
L
View
50 37879150 T161I
E
Envelope
Dengue
G
R
C
L
View
51 37879150 204delK
E
Envelope
Dengue
G
R
C
L
View
52 37879150 224delA
E
Envelope
Dengue
G
R
C
L
View
53 37879150 M297V
E
Envelope
Dengue
G
R
C
L
View
54 24551062 N290D
E
Envelope
Dengue
G
R
L
View
55 24551062 L402F
E
Envelope
Dengue
G
R
L
View
56 24551062 A473T
E
Envelope
Dengue
G
R
L
View
57 39475407 A313D
E
Envelope
Dengue
G
R
S
C
L
View
58 39475407 A313P
E
Envelope
Dengue
G
R
S
C
L
View
59 39475407 A313S
E
Envelope
Dengue
G
R
S
C
L
View
60 39475407 A313V
E
Envelope
Dengue
G
R
S
C
L
View
61 39475407 C918T
E
Envelope
Dengue
G
R
S
C
L
View
62 39475407 C938A
E
Envelope
Dengue
G
R
S
C
L
View
63 39475407 T1356C
E
Envelope
Dengue
G
R
S
C
L
View
64 39475407 T679C
E
Envelope
Dengue
G
R
S
C
L
View
65 39475407 T729C
E
Envelope
Dengue
G
R
S
C
L
View
66 27620341 A369T
E
Envelope
Dengue
G
R
S
C
L
View
67 27620341 F337I
E
Envelope
Dengue
G
R
S
C
L
View
68 27620341 L402F
E
Envelope
Dengue
G
R
S
C
L
View
69 27620341 V380I
E
Envelope
Dengue
G
R
S
C
L
View
70 39475407 S227L
E
Envelope
Dengue
G
R
S
C
L
View
71 39475407 S227P
E
Envelope
Dengue
G
R
S
C
L
View
72 39475407 S227T
E
Envelope
Dengue
G
R
S
C
L
View
73 37879150 T59A
M
prM
Dengue
G
R
C
L
View
74 37879150 E72D
M
prM
Dengue
G
R
C
L
View
75 37879150 D89E
M
prM
Dengue
G
R
C
L
View
76 37879150 A96P
M
prM
Dengue
G
R
C
L
View
77 37879150 K118R
M
prM
Dengue
G
R
C
L
View
78 37879150 A137G
M
prM
Dengue
G
R
C
L
View
79 37879150 L138F
M
prM
Dengue
G
R
C
L
View
80 24551062 R101K
NS1
NS1
Dengue
G
L
View
81 24551062 G105R
NS1
NS1
Dengue
G
L
View
82 24551062 D340E
NS1
NS1
Dengue
G
L
View
83 24551062 L349M
NS1
NS1
Dengue
G
L
View
84 19652703 E269K
E
Envelope
Dengue
G
L
View
85 19652703 E309K
E
Envelope
Dengue
G
L
View
86 19652703 T664A
E
Envelope
Dengue
G
L
View
87 19652703 K363R
E
Envelope
Dengue
G
L
View
88 19652703 S222T
E
Envelope
Dengue
G
L
View
89 37879150 P243S
E
Envelope
Dengue
G
R
C
L
View
90 37879150 I462V
E
Envelope
Dengue
G
R
C
L
View
91 37879150 T478S
E
Envelope
Dengue
G
R
C
L
View
92 37879150 I484V
E
Envelope
Dengue
G
R
C
L
View
93 33568111 I431A
E
Envelope
Dengue
G
R
S
View
94 33568111 I431V
E
Envelope
Dengue
G
R
S
View
95 27620341 N390S
E
Envelope
Dengue
G
R
S
C
L
View
96 24007412 I116T
NS2A
NS2A
Dengue
G
S
L
View
97 37692383 M1263I
NS2A
NS2A
Dengue
G
R
S
C
L
View
98 37692383 V2186I
NS4A
NS4A
Dengue
G
R
S
C
L
View
99 24007412 K861R
NS5
NS5
Dengue
G
S
L
View
100 37692383 S2644N
NS5
NS5
Dengue
G
R
S
C
L
View
101 24007412 S70A
prM
prM
Dengue
G
S
L
View
102 21872571 H346Y
E
Envelope
Dengue
G
S
L
View
103 18625078 I106V
C
Capsid
Dengue
G
S
L
View
104 28544099 R288K
E
Envelope
Dengue
G
R
S
L
View
105 26977703 I322V
E
Envelope
Dengue
G
R
S
L
View
106 26977703 I402F
E
Envelope
Dengue
G
R
S
L
View
107 26977703 N390S
E
Envelope
Dengue
G
R
S
L
View
108 37692383 V431I
E
Envelope
Dengue
G
R
S
C
L
View
109 28544099 I162V
E
Envelope
Dengue
G
R
S
L
View
110 28544099 I46T
E
Envelope
Dengue
G
R
S
L
View
111 28544099 Q52H
E
Envelope
Dengue
G
R
S
L
View
112 28544099 E71A
E
Envelope
Dengue
G
R
S
L
View
113 28544099 H149N
E
Envelope
Dengue
G
R
S
L
View
114 28544099 I164V
E
Envelope
Dengue
G
R
S
L
View
115 28544099 S203D
E
Envelope
Dengue
G
R
S
L
View
116 28544099 N390S
E
Envelope
Dengue
G
R
S
L
View
117 26977703 T404I
E
Envelope
Dengue
G
R
S
L
View
118 37692383 A1402T
NS2B
NS2B
Dengue
G
R
S
C
L
View
119 37692383 V1457I
NS2B
NS2B
Dengue
G
R
S
C
L
View
120 37692383 T2881I
NS5
NS5
Dengue
G
R
S
C
L
View
121 37692383 K3291T
NS5
NS5
Dengue
G
R
S
C
L
View
122 37692383 Q2777E
NS5
NS5
Dengue
G
R
S
C
L
View
123 37692383 R3189K
NS5
NS5
Dengue
G
R
S
C
L
View
124 37692383 Q3310R
NS5
NS5
Dengue
G
R
S
C
L
View
125 25811657 A19T
3'UTR
Dengue
G
R
S
C
L
View
126 25811657 T34C
5'UTR
Dengue
G
R
S
C
L
View
127 25811657 P43T
C
Capsid
Dengue
G
R
S
C
L
View
128 25811657 R82K
C
Capsid
Dengue
G
R
S
C
L
View
129 25811657 I322V
E
Envelope
Dengue
G
R
S
C
L
View
130 25811657 V428M
E
Envelope
Dengue
G
R
S
C
L
View
131 25811657 K36R
E
Envelope
Dengue
G
R
S
C
L
View
132 25811657 V197A
E
Envelope
Dengue
G
R
S
C
L
View
133 25811657 V250I
E
Envelope
Dengue
G
R
S
C
L
View
134 25811657 P364T
E
Envelope
Dengue
G
R
S
C
L
View
135 25811657 V164I
E
Envelope
Dengue
G
R
S
C
L
View
136 25811657 V347A
E
Envelope
Dengue
G
R
S
C
L
View
137 25811657 S103T
NS1
NS1
Dengue
G
R
S
C
L
View
138 25811657 V286A
NS1
NS1
Dengue
G
R
S
C
L
View
139 25811657 V83I
NS2A
NS2A
Dengue
G
R
S
C
L
View
140 25811657 T119N
NS2A
NS2A
Dengue
G
R
S
C
L
View
141 25811657 T42I
NS2A
NS2A
Dengue
G
R
S
C
L
View
142 25811657 L53V
NS2A
NS2A
Dengue
G
R
S
C
L
View
143 25811657 Q113H
NS2A
NS2A
Dengue
G
R
S
C
L
View
144 25811657 E118K
NS2A
NS2A
Dengue
G
R
S
C
L
View
145 25811657 L153S
NS2A
NS2A
Dengue
G
R
S
C
L
View
146 25811657 S119N
NS2A
NS2A
Dengue
G
R
S
C
L
View
147 25811657 R337K
NS3
NS3
Dengue
G
R
S
C
L
View
148 25811657 I600T
NS3
NS3
Dengue
G
R
S
C
L
View
149 25811657 K170E
NS3
NS3
Dengue
G
R
S
C
L
View
150 25811657 S171N
NS3
NS3
Dengue
G
R
S
C
L
View
151 25811657 A558V
NS3
NS3
Dengue
G
R
S
C
L
View
152 25811657 P136S
NS5
NS5
Dengue
G
R
S
C
L
View
153 25811657 E169D
NS5
NS5
Dengue
G
R
S
C
L
View
154 25811657 K548E
NS5
NS5
Dengue
G
R
S
C
L
View
155 25811657 A648T
NS5
NS5
Dengue
G
R
S
C
L
View
156 25811657 S763N
NS5
NS5
Dengue
G
R
S
C
L
View
157 25811657 D808N
NS5
NS5
Dengue
G
R
S
C
L
View
158 25811657 P829L
NS5
NS5
Dengue
G
R
S
C
L
View
159 25811657 P583Q
NS5
NS5
Dengue
G
R
S
C
L
View
160 25811657 V725A
NS5
NS5
Dengue
G
R
S
C
L
View
161 25811657 R891I
NS5
NS5
Dengue
G
R
S
C
L
View
162 25811657 A778S
NS5
NS5
Dengue
G
R
S
C
L
View
163 25811657 N645D
NS5
NS5
Dengue
G
R
S
C
L
View
164 25811657 S832T
NS5
NS5
Dengue
G
R
S
C
L
View
165 17931106 V129I
E
Envelope
Dengue
G
S
L
View
166 17931106 T117A
NS1
NS1
Dengue
G
S
L
View
167 17931106 K272R
NS1
NS1
Dengue
G
S
L
View
168 39475407 A203S
E
Envelope
Dengue
G
R
S
C
L
View
169 39475407 C2346T
E
Envelope
Dengue
G
R
S
C
L
View
170 39475407 G1541T
E
Envelope
Dengue
G
R
S
C
L
View
171 39475407 T471A
E
Envelope
Dengue
G
R
S
C
L
View
172 39475407 T471I
E
Envelope
Dengue
G
R
S
C
L
View
173 39475407 A203T
E
Envelope
Dengue
G
R
S
C
L
View
174 24007412 L178M
NS1
NS1
Dengue
G
S
L
View
175 24007412 L178S
NS1
NS1
Dengue
G
S
L
View
176 24007412 K590R
NS3
NS3
Dengue
G
S
L
View
177 24007412 M151I
NS4B
NS4B
Dengue
G
S
L
View
178 24007412 S895L
NS5
NS5
Dengue
G
S
L
View
179 24007412 Q562L
NS5
NS5
Dengue
G
S
L
View
180 24007412 T188A
NS5
NS5
Dengue
G
S
L
View
181 34342561 E123Q
E
Envelope
Dengue
G
View
182 34342561 E62K
E
Envelope
Dengue
G
View
183 37603293 G221W
E
Envelope
Dengue
G
S
L
View
184 37603293 L285P
E
Envelope
Dengue
G
S
L
View
185 37603293 T223I
E
Envelope
Dengue
G
S
L
View
186 30366083 I380T
E
Envelope
Dengue
G
S
C
L
View
187 30366083 V158I
E
Envelope
Dengue
G
S
C
L
View
188 30366083 D22Y
E
Envelope
Dengue
G
S
C
L
View
189 30366083 D71V
E
Envelope
Dengue
G
S
C
L
View
190 30366083 I140F
E
Envelope
Dengue
G
S
C
L
View
191 30366083 I141F
E
Envelope
Dengue
G
S
C
L
View
192 30366083 E154G
E
Envelope
Dengue
G
S
C
L
View
193 30366083 T317P
E
Envelope
Dengue
G
S
C
L
View
194 30366083 A329T
E
Envelope
Dengue
G
S
C
L
View
195 30366083 T443A
E
Envelope
Dengue
G
S
C
L
View
196 30366083 C477F
E
Envelope
Dengue
G
S
C
L
View
197 30366083 Y486D
E
Envelope
Dengue
G
S
C
L
View
198 30366083 Q156S
E
Envelope
Dengue
G
S
C
L
View
199 30366083 G157L
E
Envelope
Dengue
G
S
C
L
View
200 30366083 T462N
E
Envelope
Dengue
G
S
C
L
View
201 30366083 L487F
E
Envelope
Dengue
G
S
C
L
View
202 30366083 V490F
E
Envelope
Dengue
G
S
C
L
View
203 30366083 V490L
E
Envelope
Dengue
G
S
C
L
View
204 30366083 V491A
E
Envelope
Dengue
G
S
C
L
View
205 37112962 G186A
C
Capsid
Dengue
G
R
S
L
View
206 22216313 V287I
E
Envelope
Dengue
G
R
S
L
View
207 22216313 T365I
E
Envelope
Dengue
G
R
S
L
View
208 22216313 A141I
E
Envelope
Dengue
G
R
S
L
View
209 22216313 A227T
E
Envelope
Dengue
G
R
S
L
View
210 22216313 A46T
E
Envelope
Dengue
G
R
S
L
View
211 22216313 E202R
E
Envelope
Dengue
G
R
S
L
View
212 22216313 E384N
E
Envelope
Dengue
G
R
S
L
View
213 22216313 F357L
E
Envelope
Dengue
G
R
S
L
View
214 22216313 I34T
E
Envelope
Dengue
G
R
S
L
View
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217 22216313 K323Q
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232 37112962 G1602A
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NS2A
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237 37112962 K107R
NS3
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238 37112962 A4843G
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239 37112962 I563V
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NS2A
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NS2B
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NS3
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NS4A
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NS4A
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3'UTR
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3'UTR
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NS2B
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NS3
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NS3
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NS5
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NS5
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View
467 37555662 E831Q
NS5
NS5
Cell line
G
S
View
468 37555662 K301R
NS5
NS5
Cell line
G
S
View
469 37555662 Q864R
NS5
NS5
Cell line
G
S
View
470 37555662 G102R
prM
prM
Cell line
G
S
View
471 37378517 N1007D
NS1
NS1
Cell line
G
R
View
472 37378517 A3118G
NS1
NS1
Cell line
G
R
View
473 37378517 N1541S
NS3
NS3
Cell line
G
R
View
474 37378517 A4716G
NS3
NS3
Cell line
G
R
View
475 37378517 V2353A
NS4B
NS4B
Cell line
G
R
View
476 37378517 T7152C
NS4B
NS4B
Cell line
G
R
View
477 37378517 N131S
prM
prM
Cell line
G
R
View
478 37378517 A486G
prM
prM
Cell line
G
R
View
479 27716465 E216A
NS5
NS5
Cell line
G
View
480 28456663 V102A
C
Capsid
Cell line
G
S
View
481 28456663 M104V
C
Capsid
Cell line
G
S
View
482 28456663 F90Y
E
Envelope
Cell line
G
S
View
483 28456663 I141V
E
Envelope
Cell line
G
S
View
484 28456663 T173A
E
Envelope
Cell line
G
S
View
485 28456663 I322V
E
Envelope
Cell line
G
S
View
486 28456663 F103S
NS1
NS1
Cell line
G
S
View
487 28456663 T146I
NS1
NS1
Cell line
G
S
View
488 28456663 R324K
NS1
NS1
Cell line
G
S
View
489 28456663 V152I
NS2A
NS2A
Cell line
G
S
View
490 28456663 K60R
NS2B
NS2B
Cell line
G
S
View
491 28456663 I351V
NS3
NS3
Cell line
G
S
View
492 28456663 Y487H
NS3
NS3
Cell line
G
S
View
493 28456663 D535E
NS3
NS3
Cell line
G
S
View
494 28456663 V567I
NS3
NS3
Cell line
G
S
View
495 28456663 R588K
NS3
NS3
Cell line
G
S
View
496 28456663 L4M
NS4A
NS4A
Cell line
G
S
View
497 28456663 N5S
NS4A
NS4A
Cell line
G
S
View
498 28456663 A19V
NS4B
NS4B
Cell line
G
S
View
499 28456663 V43A
NS4B
NS4B
Cell line
G
S
View
500 28456663 A19S
NS5
NS5
Cell line
G
S
View
501 28456663 K30R
NS5
NS5
Cell line
G
S
View
502 28456663 V78M
NS5
NS5
Cell line
G
S
View
503 28456663 I135T
NS5
NS5
Cell line
G
S
View
504 28456663 S154P
NS5
NS5
Cell line
G
S
View
505 28456663 A196T
NS5
NS5
Cell line
G
S
View
506 28456663 G289E
NS5
NS5
Cell line
G
S
View
507 28456663 R326K
NS5
NS5
Cell line
G
S
View
508 28456663 L462I
NS5
NS5
Cell line
G
S
View
509 28456663 D521E
NS5
NS5
Cell line
G
S
View
510 28456663 V568I
NS5
NS5
Cell line
G
S
View
511 28456663 G631S
NS5
NS5
Cell line
G
S
View
512 28456663 I641V
NS5
NS5
Cell line
G
S
View
513 28456663 R644Q
NS5
NS5
Cell line
G
S
View
514 28456663 K649R
NS5
NS5
Cell line
G
S
View
515 28456663 N876S
NS5
NS5
Cell line
G
S
View
516 28456663 V135I
prM
prM
Cell line
G
S
View
517 38096749 N203D
E
Envelope
Cell line
R
I
View
518 38096749 I6M
E
Envelope
Cell line
R
View
519 34372598 T27A
NS1
NS1
Cell line
View
520 34372598 Y32A
NS1
NS1
Cell line
View
521 34372598 T29A
NS1
NS1
Cell line
View
522 34372598 T230A
NS1
NS1
Cell line
View
523 34372598 S233A
NS1
NS1
Cell line
View
524 26197333 L6E
NS4A
NS4A
Cell line
R
S
View
525 26197333 M10E
NS4A
NS4A
Cell line
R
S
View
526 30707666 A21V
NS4A
NS4A
Cell line
View
527 35865937 T7812G
NS5
NS5
Cell line
View
528 35865937 C9420A
NS5
NS5
Cell line
View
529 40216923 L1286F
NS2A
NS2A
Acute Febrile Illness
G
S
C
L
View
530 40216923 V1286F
NS2A
NS2A
Acute Febrile Illness
G
S
C
L
View
531 40216923 Y1286F
NS2A
NS2A
Acute Febrile Illness
G
S
C
L
View
532 40216923 A2762I
NS5
NS5
Acute Febrile Illness
G
S
C
L
View
533 40216923 H412Y
E
Envelope
Acute Febrile Illness
G
S
C
L
View
534 40216923 K2762I
NS5
NS5
Acute Febrile Illness
G
S
C
L
View
535 40216923 T2762I
NS5
NS5
Acute Febrile Illness
G
S
C
L
View
536 40216923 V2762I
NS5
NS5
Acute Febrile Illness
G
S
C
L
View
537 40216923 K104R
C
Capsid
Acute Febrile Illness
G
S
C
L
View
538 35149939 S135A
NS2B-NS3

G
View
539 37194462 H51N
NS2B-NS3

G
View
540 37194462 S135A
NS2B-NS3

G
View
541 38157660 H51N
NS2B-NS3

G
View
542 38157660 S135A
NS2B-NS3

G
View
543 24083095 K141S
NS3
NS3

G
View
544 32497770 T219A
E
Envelope

L
View
545 32865135 L93R
E
Envelope

View
Contents
Description

The table shows all curated mutation sites of DENV in each literature

Table Description Column Note
D
The study mentioned a certain treatment method, such as drug resistance caused by mutations.
G
The study mentioned the virus genotype/subtype information.
R
The study mentioned the reference sequence used for comparison, or the original strain of the virus used for site-directed mutagenesis.
S
The study provided sequence information or accession numbers.
L
The study provided the geographic region/country of data origin.
C
The study provided clinical baseline information.
I
The study involved information related to immune.
T
The study involved host target genes.