Browse Data by Virus Gene/Protein/Region, Disease OR Description
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Virus Gene/Protein
ORF2 ORF1 ORF3 ORF4
Disease
HEV Infection Severe Hepatitis Cell line Acute Viral Hepatitis Liver Failure, Acute Chronic Hepatitis E Liver Cirrhosis Liver Failure Hepatic Cytolysis Hepatitis-Splenomegaly Syndrome
Description
Genotype/Subtype Immune Target gene Clinical data Treatment Location Sequence data
Click the button below to quickly view the viral genes/regions/protein for mutation
Show All
ORF1
ORF2
ORF3
RdRp
ID
PMID
Mutation
Gene/Protein/Region
Encoding Gene/Protein
Disease
Description
Detail
1
19402955
I978V
ORF1
ORF1
Severe Hepatitis
G
R
S
C
L
View
2
19402955
S605P
ORF1
ORF1
Severe Hepatitis
G
R
S
C
L
View
3
19402955
V1213A
ORF1
ORF1
Severe Hepatitis
G
R
S
C
L
View
4
19402955
V239A
ORF1
ORF1
Severe Hepatitis
G
R
S
C
L
View
5
27320795
C1483W
RdRp
ORF1
Liver Failure, Acute
Acute Viral Hepatitis
G
R
S
C
L
View
6
27320795
N1530T
RdRp
ORF1
Liver Failure, Acute
Acute Viral Hepatitis
G
R
S
C
L
View
7
28359977
A341G
Methyltransferase
ORF1
Liver Failure, Acute
G
R
S
C
L
View
8
28359977
C238T
Methyltransferase
ORF1
Liver Failure, Acute
G
R
S
C
L
View
9
28359977
C267T
Methyltransferase
ORF1
Liver Failure, Acute
G
R
S
C
L
View
10
28359977
C385T
Methyltransferase
ORF1
Liver Failure, Acute
G
R
S
C
L
View
11
28359977
D29N
Methyltransferase
ORF1
Liver Failure, Acute
G
R
S
C
L
View
12
28359977
337delC
Methyltransferase
ORF1
Liver Failure, Acute
G
R
S
C
L
View
13
28359977
G115A
Methyltransferase
ORF1
Liver Failure, Acute
G
R
S
C
L
View
14
28359977
G30A
Methyltransferase
ORF1
Liver Failure, Acute
G
R
S
C
L
View
15
28359977
G86A
Methyltransferase
ORF1
Liver Failure, Acute
G
R
S
C
L
View
16
28359977
H105R
Methyltransferase
ORF1
Liver Failure, Acute
G
R
S
C
L
View
17
28359977
T107C
Methyltransferase
ORF1
Liver Failure, Acute
G
R
S
C
L
View
18
28359977
T200C
Methyltransferase
ORF1
Liver Failure, Acute
G
R
S
C
L
View
19
28359977
T222C
Methyltransferase
ORF1
Liver Failure, Acute
G
R
S
C
L
View
20
28359977
T285C
Methyltransferase
ORF1
Liver Failure, Acute
G
R
S
C
L
View
21
28359977
T288C
Methyltransferase
ORF1
Liver Failure, Acute
G
R
S
C
L
View
22
28359977
T321C
Methyltransferase
ORF1
Liver Failure, Acute
G
R
S
C
L
View
23
28359977
T390A
Methyltransferase
ORF1
Liver Failure, Acute
G
R
S
C
L
View
24
28359977
T414C
Methyltransferase
ORF1
Liver Failure, Acute
G
R
S
C
L
View
25
28359977
T441C
Methyltransferase
ORF1
Liver Failure, Acute
G
R
S
C
L
View
26
28359977
T78C
Methyltransferase
ORF1
Liver Failure, Acute
G
R
S
C
L
View
27
28359977
V27A
Methyltransferase
ORF1
Liver Failure, Acute
G
R
S
C
L
View
28
25100237
C5933T
ORF2
ORF2
Liver Failure, Acute
G
R
S
C
L
View
29
25100237
C6032T
ORF2
ORF2
Liver Failure, Acute
G
R
S
C
L
View
30
25100237
C6104T
ORF2
ORF2
Liver Failure, Acute
G
R
S
C
L
View
31
25100237
F356L
ORF2
ORF2
Liver Failure, Acute
G
R
S
C
L
View
32
25100237
G6098A
ORF2
ORF2
Liver Failure, Acute
G
R
S
C
L
View
33
25100237
K350E
ORF2
ORF2
Liver Failure, Acute
G
R
S
C
L
View
34
25100237
P259S
ORF2
ORF2
Liver Failure, Acute
G
R
S
C
L
View
35
25100237
T6014C
ORF2
ORF2
Liver Failure, Acute
G
R
S
C
L
View
36
25100237
6209delT
ORF2
ORF2
Liver Failure, Acute
G
R
S
C
L
View
37
24630891
L1110F
ORF1
ORF1
Liver Failure, Acute
G
R
View
38
24630891
V1120I
ORF1
ORF1
Liver Failure, Acute
G
R
View
39
27222534
D1384G
RdRp
ORF1
Liver Cirrhosis
Liver Failure
D
G
R
C
L
View
40
27222534
G1634R
RdRp
ORF1
Liver Cirrhosis
Liver Failure
D
G
R
C
L
View
41
27222534
K1383N
RdRp
ORF1
Liver Cirrhosis
Liver Failure
D
G
R
C
L
View
42
27222534
V1479I
RdRp
ORF1
Liver Cirrhosis
Liver Failure
D
G
R
C
L
View
43
27222534
Y1587F
RdRp
ORF1
Liver Cirrhosis
Liver Failure
D
G
R
C
L
View
44
37984761
G1634R
RdRp
ORF1
HEV Infection
Cell line
D
G
R
View
45
37984761
Y1320H
RdRp
ORF1
HEV Infection
Cell line
D
G
R
View
46
39377575
V711A
HVR
ORF2
HEV Infection
G
R
View
47
39377575
V711D
HVR
ORF2
HEV Infection
G
R
View
48
39377575
V711S
HVR
ORF2
HEV Infection
G
R
View
49
39377575
S711A
HVR
ORF2
HEV Infection
G
R
View
50
39377575
S711D
HVR
ORF2
HEV Infection
G
R
View
51
39377575
S708A
HVR
ORF2
HEV Infection
G
R
View
52
39377575
S708D
HVR
ORF2
HEV Infection
G
R
View
53
39377575
S712A
HVR
ORF2
HEV Infection
G
R
View
54
39377575
S712D
HVR
ORF2
HEV Infection
G
R
View
55
39377575
S715A
HVR
ORF2
HEV Infection
G
R
View
56
39377575
S715D
HVR
ORF2
HEV Infection
G
R
View
57
38242291
F204L
RdRp
ORF1
HEV Infection
G
R
S
L
View
58
38242291
L238F
RdRp
ORF1
HEV Infection
G
R
S
L
View
59
36942308
D1384G
RdRp
ORF1
HEV Infection
D
G
C
View
60
36942308
G1634R
RdRp
ORF1
HEV Infection
D
G
C
View
61
36942308
K1383N
RdRp
ORF1
HEV Infection
D
G
C
View
62
36942308
V1305I
RdRp
ORF1
HEV Infection
G
C
View
63
40132339
N1432Y
ORF1
ORF1
HEV Infection
G
R
C
L
View
64
40132339
P1431S
ORF1
ORF1
HEV Infection
G
R
C
L
View
65
40132339
S1453P
ORF1
ORF1
HEV Infection
G
R
C
L
View
66
40132339
V1479I
ORF1
ORF1
HEV Infection
D
G
R
C
L
View
67
40132339
E435D
ORF2
ORF2
HEV Infection
G
R
C
L
View
68
40132339
G490N
ORF2
ORF2
HEV Infection
G
R
C
L
View
69
40132339
L500F
ORF2
ORF2
HEV Infection
G
R
C
L
View
70
40132339
S483T
ORF2
ORF2
HEV Infection
G
R
C
L
View
71
40132339
S497T
ORF2
ORF2
HEV Infection
G
R
C
L
View
72
40132339
S527T
ORF2
ORF2
HEV Infection
G
R
C
L
View
73
40132339
T517S
ORF2
ORF2
HEV Infection
G
R
C
L
View
74
40132339
T529I
ORF2
ORF2
HEV Infection
G
R
C
L
View
75
40132339
V492M
ORF2
ORF2
HEV Infection
G
R
C
L
View
76
19393700
7189del
3'UTR
HEV Infection
G
R
L
View
77
25916609
V239A
Helicase
ORF1
HEV Infection
G
R
S
L
View
78
19393700
C5145T
ORF3
ORF3
HEV Infection
G
R
L
View
79
34293039
A317T
ORF1
ORF1
HEV Infection
G
R
S
L
View
80
34293039
G1634K
ORF1
ORF1
HEV Infection
D
G
R
S
L
View
81
34293039
L1110F
ORF1
ORF1
HEV Infection
G
R
S
L
View
82
34293039
L1120I
ORF1
ORF1
HEV Infection
G
R
S
L
View
83
34293039
P259S
ORF2
ORF2
HEV Infection
G
R
S
L
View
84
34293039
T735I
ORF1
ORF1
HEV Infection
G
R
S
L
View
85
34293039
V1120I
ORF1
ORF1
HEV Infection
G
R
S
L
View
86
34293039
V1479I
ORF1
ORF1
HEV Infection
D
G
R
S
L
View
87
33877740
P76L
ORF2
ORF2
HEV Infection
G
R
I
C
L
View
88
33877740
S68L
ORF2
ORF2
HEV Infection
G
R
C
L
View
89
34293039
L477T
ORF2
ORF2
HEV Infection
G
R
S
I
L
View
90
34293039
L613T
ORF2
ORF2
HEV Infection
G
R
S
I
L
View
91
33877740
A88N
ORF3
ORF3
HEV Infection
G
R
C
L
View
92
33877740
A88V
ORF3
ORF3
HEV Infection
G
R
C
L
View
93
33877740
D90G
ORF3
ORF3
HEV Infection
G
R
C
L
View
94
33877740
H81C
ORF3
ORF3
HEV Infection
G
R
I
C
L
View
95
33877740
L87P
ORF3
ORF3
HEV Infection
G
R
C
L
View
96
33877740
N82I
ORF3
ORF3
HEV Infection
G
R
C
L
View
97
33877740
P77L
ORF3
ORF3
HEV Infection
G
R
C
L
View
98
33877740
R92Q
ORF3
ORF3
HEV Infection
G
R
C
L
View
99
33877740
S79L
ORF3
ORF3
HEV Infection
G
R
I
C
L
View
100
33877740
Y80T
ORF3
ORF3
HEV Infection
G
R
C
L
View
101
35044825
G1634R
Polymerase
ORF1
HEV Infection
D
R
View
102
36809085
K1634G
RdRp
ORF1
HEV Infection
G
R
S
View
103
36809085
K1634R
RdRp
ORF1
HEV Infection
G
R
S
View
104
36809085
G1634R
RdRp
ORF1
HEV Infection
D
G
R
S
View
105
36809085
K1383N
RdRp
ORF1
HEV Infection
D
G
R
S
View
106
36809085
Y1320H
RdRp
ORF1
HEV Infection
D
G
R
S
View
107
31753030
A31T
ORF3
ORF3
Hepatitis-Splenomegaly Syndrome
R
L
View
108
31753030
G46D
ORF3
ORF3
Hepatitis-Splenomegaly Syndrome
R
L
View
109
31753030
Q35H
ORF3
ORF3
Hepatitis-Splenomegaly Syndrome
R
L
View
110
31753030
S15T
ORF3
ORF3
Hepatitis-Splenomegaly Syndrome
R
L
View
111
29656087
D442G
C
ORF2
Hepatic Cytolysis
G
R
I
C
L
View
112
29656087
V402A
C
ORF2
Hepatic Cytolysis
G
R
I
C
L
View
113
35969792
A64T
ORF2
ORF2
Chronic Hepatitis E
Cell line
D
G
R
L
View
114
35969792
G38S
ORF2
ORF2
Chronic Hepatitis E
Cell line
D
G
R
L
View
115
35969792
G71R
ORF2
ORF2
Chronic Hepatitis E
Cell line
D
G
R
L
View
116
35969792
P79S
ORF2
ORF2
Chronic Hepatitis E
Cell line
D
G
R
I
L
View
117
35969792
S95P
ORF2
ORF2
Chronic Hepatitis E
Cell line
D
G
R
L
View
118
35969792
T324S
ORF2
ORF2
Chronic Hepatitis E
Cell line
D
G
R
L
View
119
35969792
V245I
ORF2
ORF2
Chronic Hepatitis E
Cell line
D
G
R
L
View
120
25181691
G1634R
Polymerase
ORF1
Chronic Hepatitis E
D
G
R
L
View
121
27174035
G1634R
RdRp
ORF1
Chronic Hepatitis E
D
G
View
122
27174035
K1383N
RdRp
ORF1
Chronic Hepatitis E
D
G
View
123
27174035
Y1320H
RdRp
ORF1
Chronic Hepatitis E
D
G
View
124
37363232
D1384G
RdRp
ORF1
Chronic Hepatitis E
D
R
S
L
View
125
37363232
G1634K
RdRp
ORF1
Chronic Hepatitis E
D
R
S
L
View
126
37363232
K1383N
RdRp
ORF1
Chronic Hepatitis E
D
R
S
L
View
127
37363232
K1398R
RdRp
ORF1
Chronic Hepatitis E
D
R
S
L
View
128
37363232
V1479I
RdRp
ORF1
Chronic Hepatitis E
D
R
S
L
View
129
38434938
A1343V
RdRp
ORF1
Chronic Hepatitis E
D
G
View
130
38434938
G1634R
Polymerase
ORF1
Chronic Hepatitis E
D
G
View
131
36992492
A2836T
ORF1
ORF1
Cell line
HEV Infection
G
S
View
132
36992492
T2837C
ORF4
ORF4
Cell line
HEV Infection
G
S
View
133
36992492
T2885C
ORF4
ORF4
Cell line
HEV Infection
G
S
View
134
36992492
D937V
ORF1
ORF1
Cell line
HEV Infection
G
S
View
135
27485920
C3118T
Helicase
ORF1
Cell line
G
R
View
136
27485920
A5054G
RdRp
ORF1
Cell line
G
R
View
137
27485920
C4435T
RdRp
ORF1
Cell line
G
R
View
138
27485920
T2557C
X
ORF1
Cell line
G
R
View
139
27485920
T2808C
X
ORF1
Cell line
G
R
View
140
27485920
C1213T
Y
ORF1
Cell line
G
R
View
141
21152284
A606V
ORF2
ORF2
Cell line
G
R
L
View
142
21152284
L614M
ORF2
ORF2
Cell line
G
R
L
View
143
21152284
M614L
ORF2
ORF2
Cell line
G
R
View
144
21152284
V606A
ORF2
ORF2
Cell line
G
R
View
145
39793027
C18A
ORF3
ORF3
Cell line
G
T
View
146
39793027
C18S
ORF3
ORF3
Cell line
G
T
View
147
39793027
C21A
ORF3
ORF3
Cell line
G
T
View
148
39793027
C21S
ORF3
ORF3
Cell line
G
T
View
149
37276230
R458K
ORF1
ORF1
Cell line
I
T
View
150
21450834
F51L
C
ORF2
Cell line
G
View
151
21450834
S390L
C
ORF2
Cell line
G
View
152
21450834
T59A
C
ORF2
Cell line
G
View
153
37199644
F53A
PCP
ORF1
Cell line
G
R
T
View
154
29422085
I978V
Helicase
ORF1
Cell line
G
View
155
29422085
S605P
Helicase
ORF1
Cell line
G
View
156
29422085
V1213A
Helicase
ORF1
Cell line
G
View
157
29422085
A1213V
RdRp
ORF1
Cell line
G
View
158
29422085
Q1246H
RdRp
ORF1
Cell line
G
View
159
25870943
G815A
X
ORF1
Cell line
View
160
25870943
G815V
X
ORF1
Cell line
View
161
25870943
G816A
X
ORF1
Cell line
View
162
25870943
G816V
X
ORF1
Cell line
View
163
25870943
G817A
X
ORF1
Cell line
View
164
25870943
G817V
X
ORF1
Cell line
View
165
25870943
H812L
X
ORF1
Cell line
View
166
25870943
N806A
X
ORF1
Cell line
View
167
25870943
N809A
X
ORF1
Cell line
View
168
35969750
A317T
ORF1
ORF1
Cell line
G
R
View
169
35969750
F1439Y
ORF1
ORF1
Cell line
G
R
View
170
35969750
F179S
ORF1
ORF1
Cell line
G
R
View
171
35969750
T735I
ORF1
ORF1
Cell line
G
R
View
172
35969750
V1120I
ORF1
ORF1
Cell line
G
R
View
173
35969750
A27V
ORF1
ORF1
Cell line
G
R
View
174
35969750
C1483W
ORF1
ORF1
Cell line
G
R
View
175
35969750
L1110F
ORF1
ORF1
Cell line
G
R
View
176
35969750
N1530T
ORF1
ORF1
Cell line
G
R
View
177
35969750
N30D
ORF1
ORF1
Cell line
G
R
View
178
35969750
R105H
ORF1
ORF1
Cell line
G
R
View
179
35969750
A179F
ORF1
ORF1
Cell line
G
R
View
180
35969750
A179S
ORF1
ORF1
Cell line
G
R
View
181
35969750
G1634R
ORF1
ORF1
Cell line
G
R
View
182
35969750
I1120V
ORF1
ORF1
Cell line
G
R
View
183
35969750
I735T
ORF1
ORF1
Cell line
G
R
View
184
35969750
V317A
ORF1
ORF1
Cell line
G
R
View
185
35969750
V317T
ORF1
ORF1
Cell line
G
R
View
186
35969750
Y1439F
ORF1
ORF1
Cell line
G
R
View
187
31896581
G1634R
RdRp
ORF1
Cell line
D
G
R
S
I
View
188
23978667
C457A
ORF1
ORF1
Cell line
G
View
189
23978667
C459A
ORF1
ORF1
Cell line
G
View
190
23978667
C471A
ORF1
ORF1
Cell line
G
View
191
23978667
C472A
ORF1
ORF1
Cell line
G
View
192
23978667
C481A
ORF1
ORF1
Cell line
G
View
193
23978667
C483A
ORF1
ORF1
Cell line
G
View
194
23978667
G816V
ORF1
ORF1
Cell line
G
View
195
23978667
G817V
ORF1
ORF1
Cell line
G
View
196
23978667
H443L
ORF1
ORF1
Cell line
G
View
197
23978667
H497L
ORF1
ORF1
Cell line
G
View
198
23978667
H590L
ORF1
ORF1
Cell line
G
View
199
28216965
C336A
Y
ORF1
Cell line
R
View
200
28216965
C337A
Y
ORF1
Cell line
R
View
201
28216965
W413A
Y
ORF1
Cell line
R
View
202
23054435
A317T
ORF1
ORF1
Acute Viral Hepatitis
Liver Failure, Acute
G
R
S
C
L
View
203
23054435
F1439Y
ORF1
ORF1
Acute Viral Hepatitis
Liver Failure, Acute
G
R
S
C
L
View
204
23054435
F179S
ORF1
ORF1
Acute Viral Hepatitis
Liver Failure, Acute
G
R
S
C
L
View
205
23054435
I676L
ORF1
ORF1
Acute Viral Hepatitis
Liver Failure, Acute
G
R
S
C
L
View
206
23054435
L1110F
ORF1
ORF1
Acute Viral Hepatitis
Liver Failure, Acute
G
R
S
C
L
View
207
23054435
L736P
ORF1
ORF1
Acute Viral Hepatitis
Liver Failure, Acute
G
R
S
C
L
View
208
23054435
T735I
ORF1
ORF1
Acute Viral Hepatitis
Liver Failure, Acute
G
R
S
C
L
View
209
23054435
V1120I
ORF1
ORF1
Acute Viral Hepatitis
Liver Failure, Acute
G
R
S
C
L
View
210
23054435
53delI
ORF2
ORF2
Acute Viral Hepatitis
Liver Failure, Acute
G
R
S
C
L
View
211
23054435
57delQ
ORF3
ORF3
Acute Viral Hepatitis
Liver Failure, Acute
G
R
S
C
L
View
212
23054435
S58P
ORF3
ORF3
Acute Viral Hepatitis
Liver Failure, Acute
G
R
S
C
L
View
213
26784284
Q1133K
Helicase
ORF1
Acute Viral Hepatitis
G
R
S
C
L
View
214
26784284
S1014N
Helicase
ORF1
Acute Viral Hepatitis
G
R
S
C
L
View
215
26784284
S975T
Helicase
ORF1
Acute Viral Hepatitis
G
R
S
C
L
View
216
26784284
A105V
S
ORF2
Acute Viral Hepatitis
G
R
S
C
L
View
217
26784284
F10L
S
ORF2
Acute Viral Hepatitis
G
R
S
C
L
View
218
26784284
G36S
S
ORF2
Acute Viral Hepatitis
G
R
S
C
L
View
219
26784284
I113V
S
ORF2
Acute Viral Hepatitis
G
R
S
C
L
View
220
26784284
S26T
S
ORF2
Acute Viral Hepatitis
G
R
S
C
L
View
221
26784284
S70P
S
ORF2
Acute Viral Hepatitis
G
R
S
C
L
View
222
26784284
V1480I
RdRp
ORF1
Acute Viral Hepatitis
G
R
S
C
L
View
223
26784284
V1693M
RdRp
ORF1
Acute Viral Hepatitis
G
R
S
C
L
View
224
26784284
D1235G
RpRp
ORF1
Acute Viral Hepatitis
G
R
S
C
L
View
225
26784284
E1442D
RpRp
ORF1
Acute Viral Hepatitis
G
R
S
C
L
View
226
26784284
G1373V
RpRp
ORF1
Acute Viral Hepatitis
G
R
S
C
L
View
227
26784284
I1502V
RpRp
ORF1
Acute Viral Hepatitis
G
R
S
C
L
View
228
26784284
K1511R
RpRp
ORF1
Acute Viral Hepatitis
G
R
S
C
L
View
229
26784284
Q1242R
RpRp
ORF1
Acute Viral Hepatitis
G
R
S
C
L
View
230
26784284
S1454T
RpRp
ORF1
Acute Viral Hepatitis
G
R
S
C
L
View
231
26784284
S898A
X
ORF1
Acute Viral Hepatitis
G
R
S
C
L
View
232
26784284
T856V
X
ORF1
Acute Viral Hepatitis
G
R
S
C
L
View
233
26784284
T938M
X
ORF1
Acute Viral Hepatitis
G
R
S
C
L
View
234
33335573
N562C
ORF2
ORF2
Acute Viral Hepatitis
G
R
I
View
235
33335573
N562K
ORF2
ORF2
Acute Viral Hepatitis
G
R
I
View
236
33335573
N562L
ORF2
ORF2
Acute Viral Hepatitis
G
R
View