All Curated Mutation Sites in HEV 
Back to Mutation Home

 The Virus Mutation(VM) module provides researchers the annotations of reported pathogenic mutations in HEV related to human diseases. The curated VM information includes mutation site, mutation level, virus gene/protein/region, virus-associated disease, genotype/subtype, literature evidence, etc.


Browse Data by Virus Gene/Protein/Region, Disease OR Description
*Please select one option you are interested in, the page will be automatically redirected.
     
     

Click the button below to quickly view the viral genes/regions/protein for mutation

Show All
  
ORF1
  
ORF2
  
ORF3
  
RdRp
  

ID PMID Mutation Gene/Protein/Region Encoding Gene/Protein Disease Description Detail
1 19402955 I978V
ORF1
ORF1
Severe Hepatitis
G
R
S
C
L
View
2 19402955 S605P
ORF1
ORF1
Severe Hepatitis
G
R
S
C
L
View
3 19402955 V1213A
ORF1
ORF1
Severe Hepatitis
G
R
S
C
L
View
4 19402955 V239A
ORF1
ORF1
Severe Hepatitis
G
R
S
C
L
View
5 27320795 C1483W
RdRp
ORF1
Liver Failure, Acute
Acute Viral Hepatitis
G
R
S
C
L
View
6 27320795 N1530T
RdRp
ORF1
Liver Failure, Acute
Acute Viral Hepatitis
G
R
S
C
L
View
7 28359977 A341G
Methyltransferase
ORF1
Liver Failure, Acute
G
R
S
C
L
View
8 28359977 C238T
Methyltransferase
ORF1
Liver Failure, Acute
G
R
S
C
L
View
9 28359977 C267T
Methyltransferase
ORF1
Liver Failure, Acute
G
R
S
C
L
View
10 28359977 C385T
Methyltransferase
ORF1
Liver Failure, Acute
G
R
S
C
L
View
11 28359977 D29N
Methyltransferase
ORF1
Liver Failure, Acute
G
R
S
C
L
View
12 28359977 337delC
Methyltransferase
ORF1
Liver Failure, Acute
G
R
S
C
L
View
13 28359977 G115A
Methyltransferase
ORF1
Liver Failure, Acute
G
R
S
C
L
View
14 28359977 G30A
Methyltransferase
ORF1
Liver Failure, Acute
G
R
S
C
L
View
15 28359977 G86A
Methyltransferase
ORF1
Liver Failure, Acute
G
R
S
C
L
View
16 28359977 H105R
Methyltransferase
ORF1
Liver Failure, Acute
G
R
S
C
L
View
17 28359977 T107C
Methyltransferase
ORF1
Liver Failure, Acute
G
R
S
C
L
View
18 28359977 T200C
Methyltransferase
ORF1
Liver Failure, Acute
G
R
S
C
L
View
19 28359977 T222C
Methyltransferase
ORF1
Liver Failure, Acute
G
R
S
C
L
View
20 28359977 T285C
Methyltransferase
ORF1
Liver Failure, Acute
G
R
S
C
L
View
21 28359977 T288C
Methyltransferase
ORF1
Liver Failure, Acute
G
R
S
C
L
View
22 28359977 T321C
Methyltransferase
ORF1
Liver Failure, Acute
G
R
S
C
L
View
23 28359977 T390A
Methyltransferase
ORF1
Liver Failure, Acute
G
R
S
C
L
View
24 28359977 T414C
Methyltransferase
ORF1
Liver Failure, Acute
G
R
S
C
L
View
25 28359977 T441C
Methyltransferase
ORF1
Liver Failure, Acute
G
R
S
C
L
View
26 28359977 T78C
Methyltransferase
ORF1
Liver Failure, Acute
G
R
S
C
L
View
27 28359977 V27A
Methyltransferase
ORF1
Liver Failure, Acute
G
R
S
C
L
View
28 25100237 C5933T
ORF2
ORF2
Liver Failure, Acute
G
R
S
C
L
View
29 25100237 C6032T
ORF2
ORF2
Liver Failure, Acute
G
R
S
C
L
View
30 25100237 C6104T
ORF2
ORF2
Liver Failure, Acute
G
R
S
C
L
View
31 25100237 F356L
ORF2
ORF2
Liver Failure, Acute
G
R
S
C
L
View
32 25100237 G6098A
ORF2
ORF2
Liver Failure, Acute
G
R
S
C
L
View
33 25100237 K350E
ORF2
ORF2
Liver Failure, Acute
G
R
S
C
L
View
34 25100237 P259S
ORF2
ORF2
Liver Failure, Acute
G
R
S
C
L
View
35 25100237 T6014C
ORF2
ORF2
Liver Failure, Acute
G
R
S
C
L
View
36 25100237 6209delT
ORF2
ORF2
Liver Failure, Acute
G
R
S
C
L
View
37 24630891 L1110F
ORF1
ORF1
Liver Failure, Acute
G
R
View
38 24630891 V1120I
ORF1
ORF1
Liver Failure, Acute
G
R
View
39 27222534 D1384G
RdRp
ORF1
Liver Cirrhosis
Liver Failure
D
G
R
C
L
View
40 27222534 G1634R
RdRp
ORF1
Liver Cirrhosis
Liver Failure
D
G
R
C
L
View
41 27222534 K1383N
RdRp
ORF1
Liver Cirrhosis
Liver Failure
D
G
R
C
L
View
42 27222534 V1479I
RdRp
ORF1
Liver Cirrhosis
Liver Failure
D
G
R
C
L
View
43 27222534 Y1587F
RdRp
ORF1
Liver Cirrhosis
Liver Failure
D
G
R
C
L
View
44 37984761 G1634R
RdRp
ORF1
HEV Infection
Cell line
D
G
R
View
45 37984761 Y1320H
RdRp
ORF1
HEV Infection
Cell line
D
G
R
View
46 39377575 V711A
HVR
ORF2
HEV Infection
G
R
View
47 39377575 V711D
HVR
ORF2
HEV Infection
G
R
View
48 39377575 V711S
HVR
ORF2
HEV Infection
G
R
View
49 39377575 S711A
HVR
ORF2
HEV Infection
G
R
View
50 39377575 S711D
HVR
ORF2
HEV Infection
G
R
View
51 39377575 S708A
HVR
ORF2
HEV Infection
G
R
View
52 39377575 S708D
HVR
ORF2
HEV Infection
G
R
View
53 39377575 S712A
HVR
ORF2
HEV Infection
G
R
View
54 39377575 S712D
HVR
ORF2
HEV Infection
G
R
View
55 39377575 S715A
HVR
ORF2
HEV Infection
G
R
View
56 39377575 S715D
HVR
ORF2
HEV Infection
G
R
View
57 38242291 F204L
RdRp
ORF1
HEV Infection
G
R
S
L
View
58 38242291 L238F
RdRp
ORF1
HEV Infection
G
R
S
L
View
59 36942308 D1384G
RdRp
ORF1
HEV Infection
D
G
C
View
60 36942308 G1634R
RdRp
ORF1
HEV Infection
D
G
C
View
61 36942308 K1383N
RdRp
ORF1
HEV Infection
D
G
C
View
62 36942308 V1305I
RdRp
ORF1
HEV Infection
G
C
View
63 40132339 N1432Y
ORF1
ORF1
HEV Infection
G
R
C
L
View
64 40132339 P1431S
ORF1
ORF1
HEV Infection
G
R
C
L
View
65 40132339 S1453P
ORF1
ORF1
HEV Infection
G
R
C
L
View
66 40132339 V1479I
ORF1
ORF1
HEV Infection
D
G
R
C
L
View
67 40132339 E435D
ORF2
ORF2
HEV Infection
G
R
C
L
View
68 40132339 G490N
ORF2
ORF2
HEV Infection
G
R
C
L
View
69 40132339 L500F
ORF2
ORF2
HEV Infection
G
R
C
L
View
70 40132339 S483T
ORF2
ORF2
HEV Infection
G
R
C
L
View
71 40132339 S497T
ORF2
ORF2
HEV Infection
G
R
C
L
View
72 40132339 S527T
ORF2
ORF2
HEV Infection
G
R
C
L
View
73 40132339 T517S
ORF2
ORF2
HEV Infection
G
R
C
L
View
74 40132339 T529I
ORF2
ORF2
HEV Infection
G
R
C
L
View
75 40132339 V492M
ORF2
ORF2
HEV Infection
G
R
C
L
View
76 19393700 7189del
3'UTR
HEV Infection
G
R
L
View
77 25916609 V239A
Helicase
ORF1
HEV Infection
G
R
S
L
View
78 19393700 C5145T
ORF3
ORF3
HEV Infection
G
R
L
View
79 34293039 A317T
ORF1
ORF1
HEV Infection
G
R
S
L
View
80 34293039 G1634K
ORF1
ORF1
HEV Infection
D
G
R
S
L
View
81 34293039 L1110F
ORF1
ORF1
HEV Infection
G
R
S
L
View
82 34293039 L1120I
ORF1
ORF1
HEV Infection
G
R
S
L
View
83 34293039 P259S
ORF2
ORF2
HEV Infection
G
R
S
L
View
84 34293039 T735I
ORF1
ORF1
HEV Infection
G
R
S
L
View
85 34293039 V1120I
ORF1
ORF1
HEV Infection
G
R
S
L
View
86 34293039 V1479I
ORF1
ORF1
HEV Infection
D
G
R
S
L
View
87 33877740 P76L
ORF2
ORF2
HEV Infection
G
R
I
C
L
View
88 33877740 S68L
ORF2
ORF2
HEV Infection
G
R
C
L
View
89 34293039 L477T
ORF2
ORF2
HEV Infection
G
R
S
I
L
View
90 34293039 L613T
ORF2
ORF2
HEV Infection
G
R
S
I
L
View
91 33877740 A88N
ORF3
ORF3
HEV Infection
G
R
C
L
View
92 33877740 A88V
ORF3
ORF3
HEV Infection
G
R
C
L
View
93 33877740 D90G
ORF3
ORF3
HEV Infection
G
R
C
L
View
94 33877740 H81C
ORF3
ORF3
HEV Infection
G
R
I
C
L
View
95 33877740 L87P
ORF3
ORF3
HEV Infection
G
R
C
L
View
96 33877740 N82I
ORF3
ORF3
HEV Infection
G
R
C
L
View
97 33877740 P77L
ORF3
ORF3
HEV Infection
G
R
C
L
View
98 33877740 R92Q
ORF3
ORF3
HEV Infection
G
R
C
L
View
99 33877740 S79L
ORF3
ORF3
HEV Infection
G
R
I
C
L
View
100 33877740 Y80T
ORF3
ORF3
HEV Infection
G
R
C
L
View
101 35044825 G1634R
Polymerase
ORF1
HEV Infection
D
R
View
102 36809085 K1634G
RdRp
ORF1
HEV Infection
G
R
S
View
103 36809085 K1634R
RdRp
ORF1
HEV Infection
G
R
S
View
104 36809085 G1634R
RdRp
ORF1
HEV Infection
D
G
R
S
View
105 36809085 K1383N
RdRp
ORF1
HEV Infection
D
G
R
S
View
106 36809085 Y1320H
RdRp
ORF1
HEV Infection
D
G
R
S
View
107 31753030 A31T
ORF3
ORF3
Hepatitis-Splenomegaly Syndrome
R
L
View
108 31753030 G46D
ORF3
ORF3
Hepatitis-Splenomegaly Syndrome
R
L
View
109 31753030 Q35H
ORF3
ORF3
Hepatitis-Splenomegaly Syndrome
R
L
View
110 31753030 S15T
ORF3
ORF3
Hepatitis-Splenomegaly Syndrome
R
L
View
111 29656087 D442G
C
ORF2
Hepatic Cytolysis
G
R
I
C
L
View
112 29656087 V402A
C
ORF2
Hepatic Cytolysis
G
R
I
C
L
View
113 35969792 A64T
ORF2
ORF2
Chronic Hepatitis E
Cell line
D
G
R
L
View
114 35969792 G38S
ORF2
ORF2
Chronic Hepatitis E
Cell line
D
G
R
L
View
115 35969792 G71R
ORF2
ORF2
Chronic Hepatitis E
Cell line
D
G
R
L
View
116 35969792 P79S
ORF2
ORF2
Chronic Hepatitis E
Cell line
D
G
R
I
L
View
117 35969792 S95P
ORF2
ORF2
Chronic Hepatitis E
Cell line
D
G
R
L
View
118 35969792 T324S
ORF2
ORF2
Chronic Hepatitis E
Cell line
D
G
R
L
View
119 35969792 V245I
ORF2
ORF2
Chronic Hepatitis E
Cell line
D
G
R
L
View
120 25181691 G1634R
Polymerase
ORF1
Chronic Hepatitis E
D
G
R
L
View
121 27174035 G1634R
RdRp
ORF1
Chronic Hepatitis E
D
G
View
122 27174035 K1383N
RdRp
ORF1
Chronic Hepatitis E
D
G
View
123 27174035 Y1320H
RdRp
ORF1
Chronic Hepatitis E
D
G
View
124 37363232 D1384G
RdRp
ORF1
Chronic Hepatitis E
D
R
S
L
View
125 37363232 G1634K
RdRp
ORF1
Chronic Hepatitis E
D
R
S
L
View
126 37363232 K1383N
RdRp
ORF1
Chronic Hepatitis E
D
R
S
L
View
127 37363232 K1398R
RdRp
ORF1
Chronic Hepatitis E
D
R
S
L
View
128 37363232 V1479I
RdRp
ORF1
Chronic Hepatitis E
D
R
S
L
View
129 38434938 A1343V
RdRp
ORF1
Chronic Hepatitis E
D
G
View
130 38434938 G1634R
Polymerase
ORF1
Chronic Hepatitis E
D
G
View
131 36992492 A2836T
ORF1
ORF1
Cell line
HEV Infection
G
S
View
132 36992492 T2837C
ORF4
ORF4
Cell line
HEV Infection
G
S
View
133 36992492 T2885C
ORF4
ORF4
Cell line
HEV Infection
G
S
View
134 36992492 D937V
ORF1
ORF1
Cell line
HEV Infection
G
S
View
135 27485920 C3118T
Helicase
ORF1
Cell line
G
R
View
136 27485920 A5054G
RdRp
ORF1
Cell line
G
R
View
137 27485920 C4435T
RdRp
ORF1
Cell line
G
R
View
138 27485920 T2557C
X
ORF1
Cell line
G
R
View
139 27485920 T2808C
X
ORF1
Cell line
G
R
View
140 27485920 C1213T
Y
ORF1
Cell line
G
R
View
141 21152284 A606V
ORF2
ORF2
Cell line
G
R
L
View
142 21152284 L614M
ORF2
ORF2
Cell line
G
R
L
View
143 21152284 M614L
ORF2
ORF2
Cell line
G
R
View
144 21152284 V606A
ORF2
ORF2
Cell line
G
R
View
145 39793027 C18A
ORF3
ORF3
Cell line
G
T
View
146 39793027 C18S
ORF3
ORF3
Cell line
G
T
View
147 39793027 C21A
ORF3
ORF3
Cell line
G
T
View
148 39793027 C21S
ORF3
ORF3
Cell line
G
T
View
149 37276230 R458K
ORF1
ORF1
Cell line
I
T
View
150 21450834 F51L
C
ORF2
Cell line
G
View
151 21450834 S390L
C
ORF2
Cell line
G
View
152 21450834 T59A
C
ORF2
Cell line
G
View
153 37199644 F53A
PCP
ORF1
Cell line
G
R
T
View
154 29422085 I978V
Helicase
ORF1
Cell line
G
View
155 29422085 S605P
Helicase
ORF1
Cell line
G
View
156 29422085 V1213A
Helicase
ORF1
Cell line
G
View
157 29422085 A1213V
RdRp
ORF1
Cell line
G
View
158 29422085 Q1246H
RdRp
ORF1
Cell line
G
View
159 25870943 G815A
X
ORF1
Cell line
View
160 25870943 G815V
X
ORF1
Cell line
View
161 25870943 G816A
X
ORF1
Cell line
View
162 25870943 G816V
X
ORF1
Cell line
View
163 25870943 G817A
X
ORF1
Cell line
View
164 25870943 G817V
X
ORF1
Cell line
View
165 25870943 H812L
X
ORF1
Cell line
View
166 25870943 N806A
X
ORF1
Cell line
View
167 25870943 N809A
X
ORF1
Cell line
View
168 35969750 A317T
ORF1
ORF1
Cell line
G
R
View
169 35969750 F1439Y
ORF1
ORF1
Cell line
G
R
View
170 35969750 F179S
ORF1
ORF1
Cell line
G
R
View
171 35969750 T735I
ORF1
ORF1
Cell line
G
R
View
172 35969750 V1120I
ORF1
ORF1
Cell line
G
R
View
173 35969750 A27V
ORF1
ORF1
Cell line
G
R
View
174 35969750 C1483W
ORF1
ORF1
Cell line
G
R
View
175 35969750 L1110F
ORF1
ORF1
Cell line
G
R
View
176 35969750 N1530T
ORF1
ORF1
Cell line
G
R
View
177 35969750 N30D
ORF1
ORF1
Cell line
G
R
View
178 35969750 R105H
ORF1
ORF1
Cell line
G
R
View
179 35969750 A179F
ORF1
ORF1
Cell line
G
R
View
180 35969750 A179S
ORF1
ORF1
Cell line
G
R
View
181 35969750 G1634R
ORF1
ORF1
Cell line
G
R
View
182 35969750 I1120V
ORF1
ORF1
Cell line
G
R
View
183 35969750 I735T
ORF1
ORF1
Cell line
G
R
View
184 35969750 V317A
ORF1
ORF1
Cell line
G
R
View
185 35969750 V317T
ORF1
ORF1
Cell line
G
R
View
186 35969750 Y1439F
ORF1
ORF1
Cell line
G
R
View
187 31896581 G1634R
RdRp
ORF1
Cell line
D
G
R
S
I
View
188 23978667 C457A
ORF1
ORF1
Cell line
G
View
189 23978667 C459A
ORF1
ORF1
Cell line
G
View
190 23978667 C471A
ORF1
ORF1
Cell line
G
View
191 23978667 C472A
ORF1
ORF1
Cell line
G
View
192 23978667 C481A
ORF1
ORF1
Cell line
G
View
193 23978667 C483A
ORF1
ORF1
Cell line
G
View
194 23978667 G816V
ORF1
ORF1
Cell line
G
View
195 23978667 G817V
ORF1
ORF1
Cell line
G
View
196 23978667 H443L
ORF1
ORF1
Cell line
G
View
197 23978667 H497L
ORF1
ORF1
Cell line
G
View
198 23978667 H590L
ORF1
ORF1
Cell line
G
View
199 28216965 C336A
Y
ORF1
Cell line
R
View
200 28216965 C337A
Y
ORF1
Cell line
R
View
201 28216965 W413A
Y
ORF1
Cell line
R
View
202 23054435 A317T
ORF1
ORF1
Acute Viral Hepatitis
Liver Failure, Acute
G
R
S
C
L
View
203 23054435 F1439Y
ORF1
ORF1
Acute Viral Hepatitis
Liver Failure, Acute
G
R
S
C
L
View
204 23054435 F179S
ORF1
ORF1
Acute Viral Hepatitis
Liver Failure, Acute
G
R
S
C
L
View
205 23054435 I676L
ORF1
ORF1
Acute Viral Hepatitis
Liver Failure, Acute
G
R
S
C
L
View
206 23054435 L1110F
ORF1
ORF1
Acute Viral Hepatitis
Liver Failure, Acute
G
R
S
C
L
View
207 23054435 L736P
ORF1
ORF1
Acute Viral Hepatitis
Liver Failure, Acute
G
R
S
C
L
View
208 23054435 T735I
ORF1
ORF1
Acute Viral Hepatitis
Liver Failure, Acute
G
R
S
C
L
View
209 23054435 V1120I
ORF1
ORF1
Acute Viral Hepatitis
Liver Failure, Acute
G
R
S
C
L
View
210 23054435 53delI
ORF2
ORF2
Acute Viral Hepatitis
Liver Failure, Acute
G
R
S
C
L
View
211 23054435 57delQ
ORF3
ORF3
Acute Viral Hepatitis
Liver Failure, Acute
G
R
S
C
L
View
212 23054435 S58P
ORF3
ORF3
Acute Viral Hepatitis
Liver Failure, Acute
G
R
S
C
L
View
213 26784284 Q1133K
Helicase
ORF1
Acute Viral Hepatitis
G
R
S
C
L
View
214 26784284 S1014N
Helicase
ORF1
Acute Viral Hepatitis
G
R
S
C
L
View
215 26784284 S975T
Helicase
ORF1
Acute Viral Hepatitis
G
R
S
C
L
View
216 26784284 A105V
S
ORF2
Acute Viral Hepatitis
G
R
S
C
L
View
217 26784284 F10L
S
ORF2
Acute Viral Hepatitis
G
R
S
C
L
View
218 26784284 G36S
S
ORF2
Acute Viral Hepatitis
G
R
S
C
L
View
219 26784284 I113V
S
ORF2
Acute Viral Hepatitis
G
R
S
C
L
View
220 26784284 S26T
S
ORF2
Acute Viral Hepatitis
G
R
S
C
L
View
221 26784284 S70P
S
ORF2
Acute Viral Hepatitis
G
R
S
C
L
View
222 26784284 V1480I
RdRp
ORF1
Acute Viral Hepatitis
G
R
S
C
L
View
223 26784284 V1693M
RdRp
ORF1
Acute Viral Hepatitis
G
R
S
C
L
View
224 26784284 D1235G
RpRp
ORF1
Acute Viral Hepatitis
G
R
S
C
L
View
225 26784284 E1442D
RpRp
ORF1
Acute Viral Hepatitis
G
R
S
C
L
View
226 26784284 G1373V
RpRp
ORF1
Acute Viral Hepatitis
G
R
S
C
L
View
227 26784284 I1502V
RpRp
ORF1
Acute Viral Hepatitis
G
R
S
C
L
View
228 26784284 K1511R
RpRp
ORF1
Acute Viral Hepatitis
G
R
S
C
L
View
229 26784284 Q1242R
RpRp
ORF1
Acute Viral Hepatitis
G
R
S
C
L
View
230 26784284 S1454T
RpRp
ORF1
Acute Viral Hepatitis
G
R
S
C
L
View
231 26784284 S898A
X
ORF1
Acute Viral Hepatitis
G
R
S
C
L
View
232 26784284 T856V
X
ORF1
Acute Viral Hepatitis
G
R
S
C
L
View
233 26784284 T938M
X
ORF1
Acute Viral Hepatitis
G
R
S
C
L
View
234 33335573 N562C
ORF2
ORF2
Acute Viral Hepatitis
G
R
I
View
235 33335573 N562K
ORF2
ORF2
Acute Viral Hepatitis
G
R
I
View
236 33335573 N562L
ORF2
ORF2
Acute Viral Hepatitis
G
R
View
Contents
Description

The table shows all curated mutation sites of HEV in each literature

Table Description Column Note
D
The study mentioned a certain treatment method, such as drug resistance caused by mutations.
G
The study mentioned the virus genotype/subtype information.
R
The study mentioned the reference sequence used for comparison, or the original strain of the virus used for site-directed mutagenesis.
S
The study provided sequence information or accession numbers.
L
The study provided the geographic region/country of data origin.
C
The study provided clinical baseline information.
I
The study involved information related to immune.
T
The study involved host target genes.