All Curated Mutation Sites in SARS-CoV-2 
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 The Virus Mutation(VM) module provides researchers the annotations of reported pathogenic mutations in SARS-CoV-2 related to human diseases. The curated VM information includes mutation site, mutation level, virus gene/protein/region, virus-associated disease, genotype/subtype, literature evidence, etc.


Browse Data by Virus Gene/Protein/Region, Disease OR Description
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For highly variable viruses (e.g., HBV, HIV, SARS-CoV-2), ViMIC defaults to displaying mutations in a specific region. Click the green button to search for other regions, or click "Show All" to view all mutations (loading speed may be affected by network conditions).

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ORF1a
  
ORF1b
  
ORF3a
  
3CLpro
  
3'UTR
  
5'UTR
  
RBD
  
ORF7b-ORF8
  
upstream of N
  
Furin cleavage site
  
E
  
endoRNase
  
Exonuclease
  
S
  
NSP13
  
NSP3
  
M
  
Mpro
  
Methyltransferase
  
N
  
NSP14
  
NSP12
  
Non-coding region
  
NP
  
NS3
  
NS7a
  
NS7b
  
NS8
  
NSP5
  
NSP1
  
NSP10
  
NSP11
  
NSP15
  
NSP16
  
NSP2
  
NSP4
  
NSP6
  
NSP7
  
NSP8
  
NSP9
  
NTD
  
ORF8
  
ORF1ab
  
ORF9b
  
ORF10
  
ORF3
  
ORF6
  
ORF7a
  
ORF7b
  
ORF9
  
ORF9c
  
PLpro
  
RdRp
  
RBM
  
Replicase
  
RNA primase
  

Keyword: COVID-19-36846745
ID PMID Mutation Gene/Protein/Region Encoding Gene/Protein Disease Description Detail
1 36846745 T1006I
S
S
COVID-19
G
R
S
C
L
View
2 36846745 G142D
S
S
COVID-19
G
R
S
C
L
View
3 36846745 Y489Y
S
S
COVID-19
G
R
S
C
L
View
4 36846745 Y28Y
S
S
COVID-19
G
R
S
C
L
View
5 36846745 D405A
S
S
COVID-19
G
R
S
C
L
View
6 36846745 967 fs S
S
S
COVID-19
G
R
S
C
L
View
7 36846745 F565V
S
S
COVID-19
G
R
S
C
L
View
8 36846745 A65V
ORF8
ORF8
COVID-19
G
R
S
C
L
View
9 36846745 Q18X
ORF8
ORF8
COVID-19
G
R
S
C
L
View
10 36846745 P240L
ORF3a
ORF3a
COVID-19
G
R
S
C
L
View
11 36846745 H2659H
ORF1ab
ORF1ab
COVID-19
G
R
S
C
L
View
12 36846745 L3935L
ORF1ab
ORF1ab
COVID-19
G
R
S
C
L
View
13 36846745 A4577T
ORF1ab
ORF1ab
COVID-19
G
R
S
C
L
View
14 36846745 I3944T
ORF1ab
ORF1ab
COVID-19
G
R
S
C
L
View
15 36846745 G618G
ORF1ab
ORF1ab
COVID-19
G
R
S
C
L
View
16 36846745 I2501T
ORF1ab
ORF1ab
COVID-19
G
R
S
C
L
View
17 36846745 S3099L
ORF1ab
ORF1ab
COVID-19
G
R
S
C
L
View
18 36846745 L140L
ORF1ab
ORF1ab
COVID-19
G
R
S
C
L
View
19 36846745 T5775T
ORF1ab
ORF1ab
COVID-19
G
R
S
C
L
View
20 36846745 P1894S
ORF1ab
ORF1ab
COVID-19
G
R
S
C
L
View
21 36846745 G179E
ORF1ab
ORF1ab
COVID-19
G
R
S
C
L
View
22 36846745 L1683P
ORF1ab
ORF1ab
COVID-19
G
R
S
C
L
View
23 36846745 3646 fs T
ORF1ab
ORF1ab
COVID-19
G
R
S
C
L
View
24 36846745 6003 fs E
ORF1ab
ORF1ab
COVID-19
G
R
S
C
L
View
25 36846745 G6258S
ORF1ab
ORF1ab
COVID-19
G
R
S
C
L
View
26 36846745 3606 fs L
ORF1ab
ORF1ab
COVID-19
G
R
S
C
L
View
27 36846745 I284F
ORF1ab
ORF1ab
COVID-19
G
R
S
C
L
View
28 36846745 H2092Y
ORF1ab
ORF1ab
COVID-19
G
R
S
C
L
View
29 36846745 S6606P
ORF1ab
ORF1ab
COVID-19
G
R
S
C
L
View
30 36846745 F274F
N
N
COVID-19
G
R
S
C
L
View
31 36846745 R209_L221delinsM
N
N
COVID-19
G
R
S
C
L
View
32 36846745 N121N
M
M
COVID-19
G
R
S
C
L
View
33 36846745 F53F
M
M
COVID-19
G
R
S
C
L
View
Contents
Description

The table shows all curated mutation sites of SARS-CoV-2 in each literature

Table Description Column Note
D
The study mentioned a certain treatment method, such as drug resistance caused by mutations.
G
The study mentioned the virus genotype/subtype information.
R
The study mentioned the reference sequence used for comparison, or the original strain of the virus used for site-directed mutagenesis.
S
The study provided sequence information or accession numbers.
L
The study provided the geographic region/country of data origin.
C
The study provided clinical baseline information.
I
The study involved information related to immune.
T
The study involved host target genes.