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Virus Gene/Protein ORF1a ORF1b ORF3a S E M N ORF7a ORF7b ORF8 ORF1ab ORF9b ORF10 ORF6 ORF9c

Disease COVID-19All Cell line Cystic Fibrosis Pediatric Multisystem Inflammatory Disease, COVID-19 related Thrombosis, COVID-19 related HIV Infections

Description Genotype/Subtype Immune Target gene Clinical data Treatment Location Sequence data

For highly variable viruses (e.g., HBV, HIV, SARS-CoV-2), ViMIC defaults to displaying mutations in a specific region. Click the green button to search for other regions, or click "Show All" to view all mutations (loading speed may be affected by network conditions).

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ORF1a

  

ORF1b

  

ORF3a

  

3CLpro

  

3'UTR

  

5'UTR

  

RBD

  

ORF7b-ORF8

  

upstream of N

  

Furin cleavage site

  

E

  

endoRNase

  

Exonuclease

  

S

  

NSP13

  

NSP3

  

M

  

Mpro

  

Methyltransferase

  

N

  

NSP14

  

NSP12

  

Non-coding region

  

NP

  

NS3

  

NS7a

  

NS7b

  

NS8

  

NSP5

  

NSP1

  

NSP10

  

NSP11

  

NSP15

  

NSP16

  

NSP2

  

NSP4

  

NSP6

  

NSP7

  

NSP8

  

NSP9

  

NTD

  

ORF8

  

ORF1ab

  

ORF9b

  

ORF10

  

ORF3

  

ORF6

  

ORF7a

  

ORF7b

  

ORF9

  

ORF9c

  

PLpro

  

RdRp

  

RBM

  

Replicase

  

RNA primase

  

• Mutation
• Sequence

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	37243152	T21T	3CLpro	ORF1a	COVID-19	D G L	View
2	37243152	T21I	RdRp	ORF1b	COVID-19	D G L	View
3	37243152	M49I	3CLpro	ORF1a	COVID-19	D G L	View
4	37243152	M165K	3CLpro	ORF1a	COVID-19	D G L	View
5	37243152	M165M	3CLpro	ORF1a	COVID-19	D G L	View
6	37243152	M165R	3CLpro	ORF1a	COVID-19	D G L	View
7	37243152	M165T	3CLpro	ORF1a	COVID-19	D G L	View
8	37243152	D48D	3CLpro	ORF1a	COVID-19	D G L	View
9	37243152	D48H	3CLpro	ORF1a	COVID-19	D G L	View
10	37243152	D48N	3CLpro	ORF1a	COVID-19	D G L	View
11	37243152	D48Y	3CLpro	ORF1a	COVID-19	D G L	View
12	37243152	Q189K	3CLpro	ORF1a	COVID-19	D G L	View
13	37243152	F305F	RdRp	ORF1b	COVID-19	D G L	View
14	37243152	F305L	RdRp	ORF1b	COVID-19	D G L	View
15	37243152	T190I	RdRp	ORF1b	COVID-19	D G L	View
16	37243152	L167F	RdRp	ORF1b	COVID-19	D G L	View
17	37243152	L167L	RdRp	ORF1b	COVID-19	D G L	View
18	37243152	G143C	RdRp	ORF1b	COVID-19	D G L	View
19	37243152	G143G	RdRp	ORF1b	COVID-19	D G L	View
20	37243152	G143R	RdRp	ORF1b	COVID-19	D G L	View
21	37243152	G143S	RdRp	ORF1b	COVID-19	D G L	View
22	37243152	R188S	RdRp	ORF1b	COVID-19	D G L	View
23	37243152	Y54C	3CLpro	ORF1a	COVID-19	D G L	View
24	37243152	E166K	3CLpro	ORF1a	COVID-19	D G L	View
25	37243152	E166Q	3CLpro	ORF1a	COVID-19	D G L	View
26	37243152	F140I	3CLpro	ORF1a	COVID-19	D G L	View
27	37243152	F140V	3CLpro	ORF1a	COVID-19	D G L	View
28	37243152	G15C	3CLpro	ORF1a	COVID-19	D G L	View
29	37243152	G15G	3CLpro	ORF1a	COVID-19	D G L	View
30	37243152	G15R	3CLpro	ORF1a	COVID-19	D G L	View
31	37243152	H172R	3CLpro	ORF1a	COVID-19	D G L	View
32	37243152	L50C	3CLpro	ORF1a	COVID-19	D G L	View
33	37243152	L50S	3CLpro	ORF1a	COVID-19	D G L	View
34	37243152	L50Y	3CLpro	ORF1a	COVID-19	D G L	View
35	37243152	P252L	3CLpro	ORF1a	COVID-19	D G L	View
36	37243152	Q192K	3CLpro	ORF1a	COVID-19	D G L	View
37	37243152	Q192L	3CLpro	ORF1a	COVID-19	D G L	View
38	37243152	Q192P	3CLpro	ORF1a	COVID-19	D G L	View
39	37243152	Q192R	3CLpro	ORF1a	COVID-19	D G L	View
40	37243152	S144L	3CLpro	ORF1a	COVID-19	D G L	View
41	37243152	T21N	3CLpro	ORF1a	COVID-19	D G L	View
42	37243152	T21S	3CLpro	ORF1a	COVID-19	D G L	View
43	37243152	V186A	3CLpro	ORF1a	COVID-19	D G L	View
44	37243152	V186D	3CLpro	ORF1a	COVID-19	D G L	View
45	37243152	V186G	3CLpro	ORF1a	COVID-19	D G L	View
46	37243152	V186V	3CLpro	ORF1a	COVID-19	D G L	View
47	37243152	G15S	RdRp	ORF1b	COVID-19	D G L	View
48	37243152	L50F	3CLpro	ORF1a	COVID-19	D G L	View
49	37243152	L50I	3CLpro	ORF1a	COVID-19	D G L	View
50	37243152	L50L	3CLpro	ORF1a	COVID-19	D G L	View
51	37243152	L50V	3CLpro	ORF1a	COVID-19	D G L	View
52	37243152	C160C	RdRp	ORF1b	COVID-19	D G L	View
53	37243152	C160F	RdRp	ORF1b	COVID-19	D G L	View
54	37243152	C160S	RdRp	ORF1b	COVID-19	D G L	View
55	37243152	C160Y	RdRp	ORF1b	COVID-19	D G L	View
56	37243152	D248E	RdRp	ORF1b	COVID-19	D G L	View
57	37243152	T304I	RdRp	ORF1b	COVID-19	D G L	View
58	37243152	T304N	RdRp	ORF1b	COVID-19	D G L	View
59	37243152	T304S	RdRp	ORF1b	COVID-19	D G L	View
60	37243152	T304T	RdRp	ORF1b	COVID-19	D G L	View
61	37243152	F140F	RdRp	ORF1b	COVID-19	D G L	View
62	37243152	F140L	RdRp	ORF1b	COVID-19	D G L	View
63	37243152	E166A	RdRp	ORF1b	COVID-19	D G L	View
64	37243152	E166E	RdRp	ORF1b	COVID-19	D G L	View
65	37243152	E166G	RdRp	ORF1b	COVID-19	D G L	View
66	37243152	E166V	RdRp	ORF1b	COVID-19	D G L	View
67	37243152	N142D	RdRp	ORF1b	COVID-19	D G L	View
68	37243152	N142H	RdRp	ORF1b	COVID-19	D G L	View
69	37243152	N142N	RdRp	ORF1b	COVID-19	D G L	View
70	37243152	N142Y	RdRp	ORF1b	COVID-19	D G L	View
71	37243152	H172Q	RdRp	ORF1b	COVID-19	D G L	View
72	37243152	M49M	3CLpro	ORF1a	COVID-19	D G L	View
73	37243152	M49T	3CLpro	ORF1a	COVID-19	D G L	View
74	37243152	A449A	RdRp	ORF1b	COVID-19	D G L	View
75	37243152	A449D	RdRp	ORF1b	COVID-19	D G L	View
76	37243152	A449G	RdRp	ORF1b	COVID-19	D G L	View
77	37243152	A449V	RdRp	ORF1b	COVID-19	D G L	View
78	37243152	A191A	RdRp	ORF1b	COVID-19	D G L	View
79	37243152	A191E	RdRp	ORF1b	COVID-19	D G L	View
80	37243152	A191G	RdRp	ORF1b	COVID-19	D G L	View
81	37243152	A191P	RdRp	ORF1b	COVID-19	D G L	View
82	37243152	A191S	RdRp	ORF1b	COVID-19	D G L	View
83	37243152	A191T	RdRp	ORF1b	COVID-19	D G L	View
84	37243152	A191V	RdRp	ORF1b	COVID-19	D G L	View
85	37243152	A194A	RdRp	ORF1b	COVID-19	D G L	View
86	37243152	A194P	RdRp	ORF1b	COVID-19	D G L	View
87	37243152	A194S	RdRp	ORF1b	COVID-19	D G L	View
88	37243152	A194T	RdRp	ORF1b	COVID-19	D G L	View
89	37243152	A173T	3CLpro	ORF1a	COVID-19	D G L	View
90	37243152	A173V	3CLpro	ORF1a	COVID-19	D G L	View