All Curated Mutation Sites in SARS-CoV-2 
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 The Virus Mutation(VM) module provides researchers the annotations of reported pathogenic mutations in SARS-CoV-2 related to human diseases. The curated VM information includes mutation site, mutation level, virus gene/protein/region, virus-associated disease, genotype/subtype, literature evidence, etc.


Browse Data by Virus Gene/Protein/Region, Disease OR Description
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For highly variable viruses (e.g., HBV, HIV, SARS-CoV-2), ViMIC defaults to displaying mutations in a specific region. Click the green button to search for other regions, or click "Show All" to view all mutations (loading speed may be affected by network conditions).

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ORF1a
  
ORF1b
  
ORF3a
  
3CLpro
  
3'UTR
  
5'UTR
  
RBD
  
ORF7b-ORF8
  
upstream of N
  
Furin cleavage site
  
E
  
endoRNase
  
Exonuclease
  
S
  
NSP13
  
NSP3
  
M
  
Mpro
  
Methyltransferase
  
N
  
NSP14
  
NSP12
  
Non-coding region
  
NP
  
NS3
  
NS7a
  
NS7b
  
NS8
  
NSP5
  
NSP1
  
NSP10
  
NSP11
  
NSP15
  
NSP16
  
NSP2
  
NSP4
  
NSP6
  
NSP7
  
NSP8
  
NSP9
  
NTD
  
ORF8
  
ORF1ab
  
ORF9b
  
ORF10
  
ORF3
  
ORF6
  
ORF7a
  
ORF7b
  
ORF9
  
ORF9c
  
PLpro
  
RdRp
  
RBM
  
Replicase
  
RNA primase
  

Keyword: COVID-19-37243279
ID PMID Mutation Gene/Protein/Region Encoding Gene/Protein Disease Description Detail
1 37243279 L302S
RdRp
ORF1b
COVID-19
G
R
S
C
L
View
2 37243279 A85S
NSP14
ORF1b
COVID-19
G
R
S
C
L
View
3 37243279 N679K
S
S
COVID-19
G
R
S
C
L
View
4 37243279 T428I
PLpro
ORF1a
COVID-19
G
R
S
C
L
View
5 37243279 D215G
S
S
COVID-19
G
R
S
C
L
View
6 37243279 E484K
S
S
COVID-19
G
R
S
C
L
View
7 37243279 H655Y
S
S
COVID-19
G
R
S
C
L
View
8 37243279 L585F
S
S
COVID-19
G
R
S
C
L
View
9 37243279 N501Y
S
S
COVID-19
G
R
S
C
L
View
10 37243279 P25L
S
S
COVID-19
G
R
S
C
L
View
11 37243279 P9L
S
S
COVID-19
G
R
S
C
L
View
12 37243279 R190S
S
S
COVID-19
G
R
S
C
L
View
13 37243279 T716I
S
S
COVID-19
G
R
S
C
L
View
14 37243279 T859N
S
S
COVID-19
G
R
S
C
L
View
15 37243279 Y449H
S
S
COVID-19
G
R
S
C
L
View
16 37243279 T819I
PLpro
ORF1a
COVID-19
G
R
S
C
L
View
17 37243279 L275F
ORF3a
ORF3a
COVID-19
G
R
S
C
L
View
18 37243279 S216L
ORF3a
ORF3a
COVID-19
G
R
S
C
L
View
19 37243279 T229N
ORF3a
ORF3a
COVID-19
G
R
S
C
L
View
20 37243279 L438P
NSP4
ORF1a
COVID-19
G
R
S
C
L
View
21 37243279 E102K
NSP1
ORF1a
COVID-19
G
R
S
C
L
View
22 37243279 P13L
N
N
COVID-19
G
R
S
C
L
View
23 37243279 I82T
M
M
COVID-19
G
R
S
C
L
View
24 37243279 L29F
M
M
COVID-19
G
R
S
C
L
View
25 37243279 L21I
E
E
COVID-19
G
R
S
C
L
View
26 37243279 S68F
E
E
COVID-19
G
R
S
C
L
View
27 37243279 S68P
E
E
COVID-19
G
R
S
C
L
View
28 37243279 T24I
3CLpro
ORF1a
COVID-19
G
R
S
C
L
View
29 37243279 Q384H
N
N
COVID-19
G
R
S
C
L
View
30 37243279 G15S
3CLpro
ORF1a
COVID-19
G
R
S
C
L
View
31 37243279 P323L
RdRp
ORF1b
COVID-19
G
R
S
C
L
View
32 37243279 D614G
S
S
COVID-19
G
R
S
C
L
View
33 37243279 G204R
N
N
COVID-19
G
R
S
C
L
View
34 37243279 Y138H
NSP8
ORF1a
COVID-19
G
R
S
C
L
View
35 37243279 R203K
N
N
COVID-19
G
R
S
C
L
View
36 37243279 T1639A
PLpro
ORF1a
COVID-19
G
R
S
C
L
View
37 37243279 H210R
M
M
COVID-19
G
R
S
C
L
View
38 37243279 S212R
M
M
COVID-19
G
R
S
C
L
View
39 37243279 G204K
N
N
COVID-19
G
R
S
C
L
View
40 37243279 R126S
ORF3a
ORF3a
COVID-19
G
R
S
C
L
View
41 37243279 H208Y
NSP2
ORF1a
COVID-19
G
R
S
C
L
View
42 37243279 C136F
S
S
COVID-19
G
R
S
C
L
View
43 37243279 144delY
S
S
COVID-19
G
R
S
C
L
View
44 37243279 G671I
RdRp
ORF1b
COVID-19
G
R
S
C
L
View
Contents
Description

The table shows all curated mutation sites of SARS-CoV-2 in each literature

Table Description Column Note
D
The study mentioned a certain treatment method, such as drug resistance caused by mutations.
G
The study mentioned the virus genotype/subtype information.
R
The study mentioned the reference sequence used for comparison, or the original strain of the virus used for site-directed mutagenesis.
S
The study provided sequence information or accession numbers.
L
The study provided the geographic region/country of data origin.
C
The study provided clinical baseline information.
I
The study involved information related to immune.
T
The study involved host target genes.