All Curated Mutation Sites in SARS-CoV-2 
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 The Virus Mutation(VM) module provides researchers the annotations of reported pathogenic mutations in SARS-CoV-2 related to human diseases. The curated VM information includes mutation site, mutation level, virus gene/protein/region, virus-associated disease, genotype/subtype, literature evidence, etc.


Browse Data by Virus Gene/Protein/Region, Disease OR Description
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For highly variable viruses (e.g., HBV, HIV, SARS-CoV-2), ViMIC defaults to displaying mutations in a specific region. Click the green button to search for other regions, or click "Show All" to view all mutations (loading speed may be affected by network conditions).

Show All
  
ORF1a
  
ORF1b
  
ORF3a
  
3CLpro
  
3'UTR
  
5'UTR
  
RBD
  
ORF7b-ORF8
  
upstream of N
  
Furin cleavage site
  
E
  
endoRNase
  
Exonuclease
  
S
  
NSP13
  
NSP3
  
M
  
Mpro
  
Methyltransferase
  
N
  
NSP14
  
NSP12
  
Non-coding region
  
NP
  
NS3
  
NS7a
  
NS7b
  
NS8
  
NSP5
  
NSP1
  
NSP10
  
NSP11
  
NSP15
  
NSP16
  
NSP2
  
NSP4
  
NSP6
  
NSP7
  
NSP8
  
NSP9
  
NTD
  
ORF8
  
ORF1ab
  
ORF9b
  
ORF10
  
ORF3
  
ORF6
  
ORF7a
  
ORF7b
  
ORF9
  
ORF9c
  
PLpro
  
RdRp
  
RBM
  
Replicase
  
RNA primase
  

Keyword: COVID-19-37631999
ID PMID Mutation Gene/Protein/Region Encoding Gene/Protein Disease Description Detail
1 37631999 Q493R
RBD
S
COVID-19
G
R
S
L
View
2 37631999 A67V
NTD
S
COVID-19
R
S
I
L
View
3 37631999 K1245R
S
S
COVID-19
G
R
S
L
View
4 37631999 N481K
S
S
COVID-19
G
R
S
L
View
5 37631999 T604N
S
S
COVID-19
G
R
S
L
View
6 37631999 V511I
S
S
COVID-19
G
R
S
L
View
7 37631999 H1101D
S
S
COVID-19
G
R
S
L
View
8 37631999 T95I
NTD
S
COVID-19
G
R
S
L
View
9 37631999 H146Y
S
S
COVID-19
G
R
S
L
View
10 37631999 T19R
NTD
S
COVID-19
G
R
S
L
View
11 37631999 A27S
NTD
S
COVID-19
G
R
S
L
View
12 37631999 D614G
RBD
S
COVID-19
G
R
S
L
View
13 37631999 E484Q
RBD
S
COVID-19
G
R
S
L
View
14 37631999 L452R
RBD
S
COVID-19
G
R
S
L
View
15 37631999 P681R
RBD
S
COVID-19
G
R
S
L
View
16 37631999 N501Y
RBD
S
COVID-19
G
R
S
L
View
17 37631999 G142D
NTD
S
COVID-19
G
R
S
I
L
View
18 37631999 Q1071H
S
S
COVID-19
R
S
L
View
19 37631999 S929I
S
S
COVID-19
R
S
L
View
20 37631999 V382L
S
S
COVID-19
R
S
L
View
21 37631999 K417N
RBD
S
COVID-19
R
S
L
View
22 37631999 N440K
RBD
S
COVID-19
R
S
L
View
23 37631999 Q498R
RBD
S
COVID-19
R
S
L
View
24 37631999 T478K
RBD
S
COVID-19
R
S
L
View
25 37631999 Y505H
RBD
S
COVID-19
R
S
L
View
26 37631999 V70F
NTD
S
COVID-19
R
S
I
L
View
27 37631999 211del
NTD
S
COVID-19
R
S
I
L
View
28 37631999 214insEPE
NTD
S
COVID-19
R
S
I
L
View
29 37631999 K77T
NTD
S
COVID-19
R
S
L
View
30 37631999 R158G
NTD
S
COVID-19
R
S
L
View
31 37631999 A222V
NTD
S
COVID-19
R
S
L
View
32 37631999 A262S
NTD
S
COVID-19
R
S
L
View
33 37631999 E154K
NTD
S
COVID-19
R
S
L
View
34 37631999 H49Y
NTD
S
COVID-19
R
S
L
View
35 37631999 L18F
NTD
S
COVID-19
R
S
L
View
36 37631999 L5F
NTD
S
COVID-19
R
S
L
View
37 37631999 Q14H
NTD
S
COVID-19
R
S
L
View
38 37631999 T19I
NTD
S
COVID-19
R
S
L
View
39 37631999 V213G
NTD
S
COVID-19
R
S
L
View
40 37631999 Y145D
NTD
S
COVID-19
R
S
L
View
41 37631999 H655Y
S
S
COVID-19
G
R
S
L
View
42 37631999 N969K
S
S
COVID-19
G
R
S
L
View
43 37631999 Q954H
S
S
COVID-19
G
R
S
L
View
44 37631999 D796Y
S
S
COVID-19
G
R
S
L
View
45 37631999 N679K
S
S
COVID-19
G
R
S
L
View
46 37631999 N764K
S
S
COVID-19
G
R
S
L
View
47 37631999 P681H
S
S
COVID-19
G
R
S
L
View
48 37631999 A263P
S
S
COVID-19
G
R
S
L
View
Contents
Description

The table shows all curated mutation sites of SARS-CoV-2 in each literature

Table Description Column Note
D
The study mentioned a certain treatment method, such as drug resistance caused by mutations.
G
The study mentioned the virus genotype/subtype information.
R
The study mentioned the reference sequence used for comparison, or the original strain of the virus used for site-directed mutagenesis.
S
The study provided sequence information or accession numbers.
L
The study provided the geographic region/country of data origin.
C
The study provided clinical baseline information.
I
The study involved information related to immune.
T
The study involved host target genes.