All Curated Mutation Sites in SARS-CoV-2 
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 The Virus Mutation(VM) module provides researchers the annotations of reported pathogenic mutations in SARS-CoV-2 related to human diseases. The curated VM information includes mutation site, mutation level, virus gene/protein/region, virus-associated disease, genotype/subtype, literature evidence, etc.


Browse Data by Virus Gene/Protein/Region, Disease OR Description
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For highly variable viruses (e.g., HBV, HIV, SARS-CoV-2), ViMIC defaults to displaying mutations in a specific region. Click the green button to search for other regions, or click "Show All" to view all mutations (loading speed may be affected by network conditions).

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ORF1a
  
ORF1b
  
ORF3a
  
3CLpro
  
3'UTR
  
5'UTR
  
RBD
  
ORF7b-ORF8
  
upstream of N
  
Furin cleavage site
  
E
  
endoRNase
  
Exonuclease
  
S
  
NSP13
  
NSP3
  
M
  
Mpro
  
Methyltransferase
  
N
  
NSP14
  
NSP12
  
Non-coding region
  
NP
  
NS3
  
NS7a
  
NS7b
  
NS8
  
NSP5
  
NSP1
  
NSP10
  
NSP11
  
NSP15
  
NSP16
  
NSP2
  
NSP4
  
NSP6
  
NSP7
  
NSP8
  
NSP9
  
NTD
  
ORF8
  
ORF1ab
  
ORF9b
  
ORF10
  
ORF3
  
ORF6
  
ORF7a
  
ORF7b
  
ORF9
  
ORF9c
  
PLpro
  
RdRp
  
RBM
  
Replicase
  
RNA primase
  

Keyword: COVID-19-38791536
ID PMID Mutation Gene/Protein/Region Encoding Gene/Protein Disease Description Detail
1 38791536 L436S
NSP4
ORF1a
COVID-19
G
R
L
View
2 38791536 K776R
S
S
COVID-19
G
R
L
View
3 38791536 Y453F
RBD
S
COVID-19
G
R
I
L
View
4 38791536 A656V
ORF1a
ORF1a
COVID-19
G
R
L
View
5 38791536 P3952S
ORF1a
ORF1a
COVID-19
G
R
L
View
6 38791536 R78C
ORF7a
ORF7a
COVID-19
G
R
L
View
7 38791536 G2610N
ORF1b
ORF1b
COVID-19
G
R
L
View
8 38791536 I117L
ORF1b
ORF1b
COVID-19
G
R
L
View
9 38791536 L3199S
ORF1a
ORF1a
COVID-19
G
R
L
View
10 38791536 A182S
N
N
COVID-19
G
R
L
View
11 38791536 G5V
N
N
COVID-19
G
R
L
View
12 38791536 S235F
N
N
COVID-19
G
R
L
View
13 38791536 D571G
S
S
COVID-19
R
L
View
14 38791536 D796H
S
S
COVID-19
R
L
View
15 38791536 F759S
S
S
COVID-19
R
L
View
16 38791536 P793S
S
S
COVID-19
R
L
View
17 38791536 S816T
S
S
COVID-19
R
L
View
18 38791536 F486L
S
S
COVID-19
R
L
View
19 38791536 G142D
S
S
COVID-19
R
L
View
20 38791536 S830P
PLpro
ORF1a
COVID-19
R
L
View
21 38791536 T976A
PLpro
ORF1a
COVID-19
R
L
View
22 38791536 G2640R
ORF1a
ORF1a
COVID-19
R
L
View
23 38791536 T256I
ORF1a
ORF1a
COVID-19
R
L
View
24 38791536 W2008C
ORF1a
ORF1a
COVID-19
R
L
View
25 38791536 L54F
NTD
S
COVID-19
R
L
View
26 38791536 R158G
NTD
S
COVID-19
R
L
View
27 38791536 V227I
NTD
S
COVID-19
R
L
View
28 38791536 G37E
NSP9
ORF1a
COVID-19
R
L
View
29 38791536 Q1821R
NSP3
ORF1a
COVID-19
R
L
View
30 38791536 S486L
NSP13
ORF1b
COVID-19
R
L
View
31 38791536 S468L
NSP13
ORF1b
COVID-19
R
L
View
32 38791536 S967N
S
S
COVID-19
R
L
View
33 38791536 F486V
S
S
COVID-19
R
L
View
34 38791536 N501T
RBD
S
COVID-19
R
L
View
35 38791536 G4177E
ORF1a
ORF1a
COVID-19
R
L
View
36 38791536 W1190C
NSP3
ORF1a
COVID-19
R
L
View
37 38791536 G1822R
NSP3
ORF1a
COVID-19
R
L
View
Contents
Description

The table shows all curated mutation sites of SARS-CoV-2 in each literature

Table Description Column Note
D
The study mentioned a certain treatment method, such as drug resistance caused by mutations.
G
The study mentioned the virus genotype/subtype information.
R
The study mentioned the reference sequence used for comparison, or the original strain of the virus used for site-directed mutagenesis.
S
The study provided sequence information or accession numbers.
L
The study provided the geographic region/country of data origin.
C
The study provided clinical baseline information.
I
The study involved information related to immune.
T
The study involved host target genes.