All Curated Mutation Sites in SARS-CoV-2 
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 The Virus Mutation(VM) module provides researchers the annotations of reported pathogenic mutations in SARS-CoV-2 related to human diseases. The curated VM information includes mutation site, mutation level, virus gene/protein/region, virus-associated disease, genotype/subtype, literature evidence, etc.


Browse Data by Virus Gene/Protein/Region, Disease OR Description
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For highly variable viruses (e.g., HBV, HIV, SARS-CoV-2), ViMIC defaults to displaying mutations in a specific region. Click the green button to search for other regions, or click "Show All" to view all mutations (loading speed may be affected by network conditions).

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ORF1a
  
ORF1b
  
ORF3a
  
3CLpro
  
3'UTR
  
5'UTR
  
RBD
  
ORF7b-ORF8
  
upstream of N
  
Furin cleavage site
  
E
  
endoRNase
  
Exonuclease
  
S
  
NSP13
  
NSP3
  
M
  
Mpro
  
Methyltransferase
  
N
  
NSP14
  
NSP12
  
Non-coding region
  
NP
  
NS3
  
NS7a
  
NS7b
  
NS8
  
NSP5
  
NSP1
  
NSP10
  
NSP11
  
NSP15
  
NSP16
  
NSP2
  
NSP4
  
NSP6
  
NSP7
  
NSP8
  
NSP9
  
NTD
  
ORF8
  
ORF1ab
  
ORF9b
  
ORF10
  
ORF3
  
ORF6
  
ORF7a
  
ORF7b
  
ORF9
  
ORF9c
  
PLpro
  
RdRp
  
RBM
  
Replicase
  
RNA primase
  

Keyword: COVID-19-39349594
ID PMID Mutation Gene/Protein/Region Encoding Gene/Protein Disease Description Detail
1 39349594 E484A
RBD
S
COVID-19
G
View
2 39349594 G339D
RBD
S
COVID-19
G
View
3 39349594 G446S
RBD
S
COVID-19
G
View
4 39349594 G496S
RBD
S
COVID-19
G
View
5 39349594 N440K
RBD
S
COVID-19
G
View
6 39349594 Q493R
RBD
S
COVID-19
G
View
7 39349594 Q498R
RBD
S
COVID-19
G
View
8 39349594 S371L
RBD
S
COVID-19
G
View
9 39349594 S373P
RBD
S
COVID-19
G
View
10 39349594 S375F
RBD
S
COVID-19
G
View
11 39349594 Y505H
RBD
S
COVID-19
G
View
12 39349594 R346K
RBD
S
COVID-19
G
View
13 39349594 S477N
RBD
S
COVID-19
G
View
14 39349594 F490S
S
S
COVID-19
G
I
View
15 39349594 L452Q
S
S
COVID-19
G
I
View
16 39349594 E484Q
RBD
S
COVID-19
G
View
17 39349594 K417Y
S
S
COVID-19
G
View
18 39349594 N439R
S
S
COVID-19
G
View
19 39349594 V445L
S
S
COVID-19
G
View
20 39349594 Y489F
S
S
COVID-19
G
View
21 39349594 K417T
RBD
S
COVID-19
G
View
22 39349594 T478K
RBD
S
COVID-19
G
View
23 39349594 L452R
RBD
S
COVID-19
G
View
24 39349594 K417N
RBD
S
COVID-19
G
View
25 39349594 N501Y
RBD
S
COVID-19
G
I
View
26 39349594 E484K
S
S
COVID-19
G
View
27 39349594 F490L
S
S
COVID-19
I
View
28 39349594 G446V
S
S
COVID-19
I
View
29 39349594 Q498I
S
S
COVID-19
View
30 39349594 Y505F
RBD
S
COVID-19
G
View
Contents
Description

The table shows all curated mutation sites of SARS-CoV-2 in each literature

Table Description Column Note
D
The study mentioned a certain treatment method, such as drug resistance caused by mutations.
G
The study mentioned the virus genotype/subtype information.
R
The study mentioned the reference sequence used for comparison, or the original strain of the virus used for site-directed mutagenesis.
S
The study provided sequence information or accession numbers.
L
The study provided the geographic region/country of data origin.
C
The study provided clinical baseline information.
I
The study involved information related to immune.
T
The study involved host target genes.