All Curated Mutation Sites in SARS-CoV-2 
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 The Virus Mutation(VM) module provides researchers the annotations of reported pathogenic mutations in SARS-CoV-2 related to human diseases. The curated VM information includes mutation site, mutation level, virus gene/protein/region, virus-associated disease, genotype/subtype, literature evidence, etc.


Browse Data by Virus Gene/Protein/Region, Disease OR Description
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For highly variable viruses (e.g., HBV, HIV, SARS-CoV-2), ViMIC defaults to displaying mutations in a specific region. Click the green button to search for other regions, or click "Show All" to view all mutations (loading speed may be affected by network conditions).

Show All
  
ORF1a
  
ORF1b
  
ORF3a
  
3CLpro
  
3'UTR
  
5'UTR
  
RBD
  
ORF7b-ORF8
  
upstream of N
  
Furin cleavage site
  
E
  
endoRNase
  
Exonuclease
  
S
  
NSP13
  
NSP3
  
M
  
Mpro
  
Methyltransferase
  
N
  
NSP14
  
NSP12
  
Non-coding region
  
NP
  
NS3
  
NS7a
  
NS7b
  
NS8
  
NSP5
  
NSP1
  
NSP10
  
NSP11
  
NSP15
  
NSP16
  
NSP2
  
NSP4
  
NSP6
  
NSP7
  
NSP8
  
NSP9
  
NTD
  
ORF8
  
ORF1ab
  
ORF9b
  
ORF10
  
ORF3
  
ORF6
  
ORF7a
  
ORF7b
  
ORF9
  
ORF9c
  
PLpro
  
RdRp
  
RBM
  
Replicase
  
RNA primase
  

Keyword: COVID-19-40143342
ID PMID Mutation Gene/Protein/Region Encoding Gene/Protein Disease Description Detail
1 40143342 L452R
S
S
COVID-19
G
R
S
L
View
2 40143342 P681R
S
S
COVID-19
G
R
S
I
L
View
3 40143342 A653V
S
S
COVID-19
R
S
L
View
4 40143342 D614G
S
S
COVID-19
R
S
L
View
5 40143342 E484D
S
S
COVID-19
R
S
L
View
6 40143342 N74K
S
S
COVID-19
R
S
L
View
7 40143342 P812L
S
S
COVID-19
R
S
L
View
8 40143342 Q992H
S
S
COVID-19
R
S
L
View
9 40143342 S730T
S
S
COVID-19
R
S
L
View
10 40143342 S813I
S
S
COVID-19
R
S
L
View
11 40143342 T29I
S
S
COVID-19
R
S
L
View
12 40143342 T478K
S
S
COVID-19
R
S
I
L
View
13 40143342 T716I
S
S
COVID-19
R
S
L
View
14 40143342 T76I
S
S
COVID-19
R
S
L
View
15 40143342 T95I
S
S
COVID-19
R
S
L
View
16 40143342 F120L
ORF8
ORF8
COVID-19
R
S
L
View
17 40143342 R52I
ORF8
ORF8
COVID-19
R
S
L
View
18 40143342 Y73C
ORF8
ORF8
COVID-19
R
S
L
View
19 40143342 T40I
ORF7b
ORF7b
COVID-19
R
S
L
View
20 40143342 E92K
ORF7a
ORF7a
COVID-19
R
S
L
View
21 40143342 L116F
ORF7a
ORF7a
COVID-19
R
S
L
View
22 40143342 P45L
ORF7a
ORF7a
COVID-19
R
S
L
View
23 40143342 T120I
ORF7a
ORF7a
COVID-19
R
S
L
View
24 40143342 V82A
ORF7a
ORF7a
COVID-19
R
S
L
View
25 40143342 A99V
ORF3a
ORF3a
COVID-19
R
S
L
View
26 40143342 P240S
ORF3a
ORF3a
COVID-19
R
S
L
View
27 40143342 S26L
ORF3a
ORF3a
COVID-19
R
S
L
View
28 40143342 W149L
ORF3a
ORF3a
COVID-19
R
S
L
View
29 40143342 C3037T
ORF1ab
ORF1ab
COVID-19
R
S
L
View
30 40143342 P218L
ORF1ab
ORF1ab
COVID-19
R
S
L
View
31 40143342 P314L
ORF1ab
ORF1ab
COVID-19
R
S
L
View
32 40143342 P77L
ORF1ab
ORF1ab
COVID-19
R
S
L
View
33 40143342 D377Y
N
N
COVID-19
R
S
L
View
34 40143342 D3L
N
N
COVID-19
R
S
L
View
35 40143342 D63G
N
N
COVID-19
R
S
L
View
36 40143342 G215C
N
N
COVID-19
R
S
L
View
37 40143342 K388I
N
N
COVID-19
R
S
L
View
38 40143342 R203M
N
N
COVID-19
R
S
L
View
39 40143342 S235F
N
N
COVID-19
R
S
L
View
40 40143342 H125Y
M
M
COVID-19
R
S
L
View
41 40143342 I82T
M
M
COVID-19
R
S
L
View
42 40143342 K162N
M
M
COVID-19
R
S
L
View
43 40143342 C241T
5'UTR
COVID-19
R
S
L
View
44 40143342 I212N COVID-19
R
S
L
View
Contents
Description

The table shows all curated mutation sites of SARS-CoV-2 in each literature

Table Description Column Note
D
The study mentioned a certain treatment method, such as drug resistance caused by mutations.
G
The study mentioned the virus genotype/subtype information.
R
The study mentioned the reference sequence used for comparison, or the original strain of the virus used for site-directed mutagenesis.
S
The study provided sequence information or accession numbers.
L
The study provided the geographic region/country of data origin.
C
The study provided clinical baseline information.
I
The study involved information related to immune.
T
The study involved host target genes.