All Curated Mutation Sites in HBV 
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 The Virus Mutation(VM) module provides researchers the annotations of reported pathogenic mutations in HBV related to human diseases. The curated VM information includes mutation site, mutation level, virus gene/protein/region, virus-associated disease, genotype/subtype, literature evidence, etc.


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For highly variable viruses (e.g., HBV, HIV, SARS-CoV-2), ViMIC defaults to displaying mutations in a specific region. Click the green button to search for other regions, or click "Show All" to view all mutations (loading speed may be affected by network conditions).

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S
  
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C
  
Core Promoter
  
Core Upstream Regulatory Sequence
  
DR1
  
EnhI
  
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PreC
  
P
  
PreC Promoter
  
PreS
  
PreS1
  
PreS1 Promoter
  
PreS2
  
RT
  
S Promoter
  
S1 Promoter
  
S2 Promoter
  
X Promoter
  

Keyword: Carcinoma, Hepatocellular-22882650
ID PMID Mutation Gene/Protein/Region Encoding Gene/Protein Disease Description Detail
1 22882650 V173L
RT
P
Hepatitis B, Chronic
Carcinoma, Hepatocellular
D
G
R
C
L
View
2 22882650 L80I
RT
P
Hepatitis B, Chronic
Carcinoma, Hepatocellular
G
R
C
L
View
3 22882650 L80V
RT
P
Hepatitis B, Chronic
Carcinoma, Hepatocellular
G
R
C
L
View
4 22882650 Q215H
RT
P
Hepatitis B, Chronic
Carcinoma, Hepatocellular
G
R
C
L
View
5 22882650 A181T
RT
P
Carcinoma, Hepatocellular
D
G
R
C
L
View
6 22882650 D134E
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
7 22882650 D134G
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
8 22882650 D134N
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
9 22882650 D134S
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
10 22882650 M204I
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
D
G
R
C
L
View
11 22882650 M204V
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
D
G
R
C
L
View
12 22882650 S106C
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
13 22882650 V214A
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
D
G
R
C
L
View
14 22882650 V214E
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
D
G
R
C
L
View
15 22882650 V214I
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
D
G
R
C
L
View
16 22882650 M204S
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
D
G
R
C
L
View
17 22882650 F221Y
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
18 22882650 G127R
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
19 22882650 G127W
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
20 22882650 H126D
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
21 22882650 H126Y
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
22 22882650 I122F
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
23 22882650 I122K
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
24 22882650 I122L
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
25 22882650 I122N
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
26 22882650 I122S
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
27 22882650 I163V
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
28 22882650 I91L
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
29 22882650 L145M
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
30 22882650 L145V
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
31 22882650 L199F
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
32 22882650 L199M
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
33 22882650 L199V
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
34 22882650 L229M
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
35 22882650 L229V
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
36 22882650 L229W
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
37 22882650 M129L
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
38 22882650 M129V
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
39 22882650 N121I
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
40 22882650 N123D
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
41 22882650 N123F
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
42 22882650 N123H
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
43 22882650 N123Y
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
44 22882650 N139A
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
45 22882650 N139D
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
46 22882650 N139H
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
47 22882650 N139K
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
48 22882650 N139T
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
49 22882650 N139Y
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
50 22882650 N238A
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
51 22882650 N238D
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
52 22882650 N238H
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
53 22882650 N238Q
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
54 22882650 N238S
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
55 22882650 N238T
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
56 22882650 N248H
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
57 22882650 Q125H
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
58 22882650 Q125K
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
59 22882650 Q125N
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
60 22882650 Q125R
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
61 22882650 R110G
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
62 22882650 R110Q
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
63 22882650 R138K
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
64 22882650 R138Q
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
65 22882650 S135F
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
66 22882650 S135P
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
67 22882650 S135T
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
68 22882650 S135Y
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
69 22882650 S137Q
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
70 22882650 S137T
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
71 22882650 S213N
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
72 22882650 S213T
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
73 22882650 S219A
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
74 22882650 S219T
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
75 22882650 S78T
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
76 22882650 T118A
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
77 22882650 T118N
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
78 22882650 T118S
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
79 22882650 T128A
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
80 22882650 T128N
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
81 22882650 T128P
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
82 22882650 V191I
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
83 22882650 V253A
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
84 22882650 V253E
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
85 22882650 V253R
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
86 22882650 Y124D
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
87 22882650 Y124H
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
88 22882650 Y124N
RT
P
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
Contents
Description

The table shows all curated mutation sites of HBV in each literature

Table Description Column Note
D
The study mentioned a certain treatment method, such as drug resistance caused by mutations.
G
The study mentioned the virus genotype/subtype information.
R
The study mentioned the reference sequence used for comparison, or the original strain of the virus used for site-directed mutagenesis.
S
The study provided sequence information or accession numbers.
L
The study provided the geographic region/country of data origin.
C
The study provided clinical baseline information.
I
The study involved information related to immune.
T
The study involved host target genes.