All Curated Mutation Sites in HBV 
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 The Virus Mutation(VM) module provides researchers the annotations of reported pathogenic mutations in HBV related to human diseases. The curated VM information includes mutation site, mutation level, virus gene/protein/region, virus-associated disease, genotype/subtype, literature evidence, etc.


Browse Data by Virus Gene/Protein/Region, Disease OR Description
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For highly variable viruses (e.g., HBV, HIV, SARS-CoV-2), ViMIC defaults to displaying mutations in a specific region. Click the green button to search for other regions, or click "Show All" to view all mutations (loading speed may be affected by network conditions).

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S
  
BCP
  
X
  
C
  
Core Promoter
  
Core Upstream Regulatory Sequence
  
DR1
  
EnhI
  
EnhII
  
PreC
  
P
  
PreC Promoter
  
PreS
  
PreS1
  
PreS1 Promoter
  
PreS2
  
RT
  
S Promoter
  
S1 Promoter
  
S2 Promoter
  
X Promoter
  

Keyword: Carcinoma, Hepatocellular-31105017
ID PMID Mutation Gene/Protein/Region Encoding Gene/Protein Disease Description Detail
1 31105017 Y206C
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
2 31105017 Y206F
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
3 31105017 Y206H
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
4 31105017 Y206L
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
5 31105017 Y206S
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
6 31105017 C221Y
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
7 31105017 G130K
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
8 31105017 G130R
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
9 31105017 I82T
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
10 31105017 P214L
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
11 31105017 P214Q
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
12 31105017 Q101R
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
L
View
13 31105017 S207N
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
14 31105017 S207R
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
15 31105017 S207T
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
16 31105017 T126R
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
17 31105017 T126S
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
L
View
18 31105017 W182L
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
19 31105017 Y225S
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
L
View
20 31105017 C107X
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
21 31105017 C69X
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
L
View
22 31105017 G159X
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
23 31105017 L216X
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
24 31105017 L94X
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
25 31105017 L95X
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
26 31105017 W182X
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
27 31105017 A157V
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
28 31105017 C124G
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
29 31105017 D144A
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
30 31105017 F158V
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
31 31105017 F179S
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
32 31105017 F212S
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
33 31105017 F220S
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
34 31105017 F80S
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
35 31105017 F85C
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
36 31105017 G159A
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
37 31105017 G159V
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
38 31105017 G44E
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
39 31105017 I110L
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
40 31105017 I110T
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
41 31105017 I152S
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
42 31105017 I208T
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
43 31105017 I92T
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
44 31105017 K141E
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
45 31105017 L104W
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
46 31105017 L109P
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
47 31105017 L186C
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
48 31105017 L186F
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
49 31105017 L209S
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
50 31105017 L213I
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
51 31105017 L215P
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
52 31105017 L49R
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
53 31105017 L88P
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
54 31105017 L89Q
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
55 31105017 M103T
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
56 31105017 M133I
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
57 31105017 M197T
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
58 31105017 P127T
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
59 31105017 P217L
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
60 31105017 P62L
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
61 31105017 P62Q
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
62 31105017 Q181H
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
63 31105017 Q30K
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
64 31105017 Q54R
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
65 31105017 R122T
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
66 31105017 S114P
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
67 31105017 S193L
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
68 31105017 S210K
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
69 31105017 S210R
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
70 31105017 S210T
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
71 31105017 S53L
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
72 31105017 S64F
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
73 31105017 T115N
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
74 31105017 T118A
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
75 31105017 T140I
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
76 31105017 T148I
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
77 31105017 T189I
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
78 31105017 V106D
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
79 31105017 V177A
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
80 31105017 V177L
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
81 31105017 V184G
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
82 31105017 V96A
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
83 31105017 Y134H
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
84 31105017 G130X
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
L
View
85 31105017 G145R
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
L
View
86 31105017 M133R
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
L
View
87 31105017 R122K
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
L
View
88 31105017 S143L
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
L
View
89 31105017 T140N
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
L
View
90 31105017 C76Y
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
L
View
91 31105017 I134L
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
L
View
92 31105017 L205M
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
L
View
93 31105017 L71R
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
L
View
94 31105017 L77R
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
L
View
95 31105017 R79H
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
L
View
96 31105017 S204C
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
L
View
97 31105017 S204K
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
L
View
98 31105017 S204N
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
L
View
99 31105017 S204R
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
L
View
100 31105017 S207H
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
L
View
101 31105017 V224A
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
L
View
102 31105017 A194T
RT
P
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
L
View
103 31105017 Q215S
RT
P
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
L
View
104 31105017 V191I
RT
P
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
L
View
105 31105017 V214A
RT
P
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
L
View
106 31105017 P120S
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
107 31105017 P120T
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
108 31105017 Y134F
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
109 31105017 Y134L
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
110 31105017 Y134N
S
S
Liver Cirrhosis
Carcinoma, Hepatocellular
G
R
I
L
View
Contents
Description

The table shows all curated mutation sites of HBV in each literature

Table Description Column Note
D
The study mentioned a certain treatment method, such as drug resistance caused by mutations.
G
The study mentioned the virus genotype/subtype information.
R
The study mentioned the reference sequence used for comparison, or the original strain of the virus used for site-directed mutagenesis.
S
The study provided sequence information or accession numbers.
L
The study provided the geographic region/country of data origin.
C
The study provided clinical baseline information.
I
The study involved information related to immune.
T
The study involved host target genes.