All Curated Mutation Sites in HBV 
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 The Virus Mutation(VM) module provides researchers the annotations of reported pathogenic mutations in HBV related to human diseases. The curated VM information includes mutation site, mutation level, virus gene/protein/region, virus-associated disease, genotype/subtype, literature evidence, etc.


Browse Data by Virus Gene/Protein/Region, Disease OR Description
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For highly variable viruses (e.g., HBV, HIV, SARS-CoV-2), ViMIC defaults to displaying mutations in a specific region. Click the green button to search for other regions, or click "Show All" to view all mutations (loading speed may be affected by network conditions).

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S
  
BCP
  
X
  
C
  
Core Promoter
  
Core Upstream Regulatory Sequence
  
DR1
  
EnhI
  
EnhII
  
PreC
  
P
  
PreC Promoter
  
PreS
  
PreS1
  
PreS1 Promoter
  
PreS2
  
RT
  
S Promoter
  
S1 Promoter
  
S2 Promoter
  
X Promoter
  

Keyword: Carcinoma, Hepatocellular-35415256
ID PMID Mutation Gene/Protein/Region Encoding Gene/Protein Disease Description Detail
1 35415256 G1896A
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
2 35415256 A131P
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
3 35415256 A54V
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
4 35415256 A69G
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
5 35415256 A69P
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
6 35415256 A69S
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
7 35415256 C61R
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
8 35415256 D78A
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
9 35415256 E113D
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
10 35415256 E113Q
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
11 35415256 E14D
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
12 35415256 E14Q
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
13 35415256 E40D
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
14 35415256 E40Q
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
15 35415256 E64D
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
16 35415256 E64N
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
17 35415256 E77D
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
18 35415256 E77Q
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
19 35415256 F24Y
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
20 35415256 G153C
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
21 35415256 G29D
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
22 35415256 G63W
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
23 35415256 G73V
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
24 35415256 I105L
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
25 35415256 I105T
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
26 35415256 I105V
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
27 35415256 I116K
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
28 35415256 I116L
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
29 35415256 I116V
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
30 35415256 I139L
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
31 35415256 I149
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
32 35415256 I59T
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
33 35415256 I59V
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
34 35415256 I59Y
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
35 35415256 I80A
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
36 35415256 I80T
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
37 35415256 I80V
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
38 35415256 L143P
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
39 35415256 L16I
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
40 35415256 L68P
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
41 35415256 L76V
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
42 35415256 L84P
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
43 35415256 L84Q
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
44 35415256 M66I
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
45 35415256 M66L
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
46 35415256 M93L
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
47 35415256 M93W
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
48 35415256 N92H
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
49 35415256 N92T
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
50 35415256 P129L
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
51 35415256 P130L
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
52 35415256 P130Q
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
53 35415256 P135Q
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
54 35415256 P135T
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
55 35415256 P25T
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
56 35415256 P45S
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
57 35415256 P50A
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
58 35415256 P79Q
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
59 35415256 P79T
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
60 35415256 Q182H
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
61 35415256 Q182K
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
62 35415256 R127A
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
63 35415256 R127G
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
64 35415256 R133G
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
65 35415256 R151G
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
66 35415256 R151P
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
67 35415256 R151Q
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
68 35415256 R151S
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
69 35415256 R174I
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
70 35415256 R174K
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
71 35415256 R174T
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
72 35415256 R56G
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
73 35415256 S155A
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
74 35415256 S155F
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
75 35415256 S155T
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
76 35415256 S181P
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
77 35415256 S181R
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
78 35415256 S21P
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
I
C
L
 View
79 35415256 S21T
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
I
C
L
 View
80 35415256 S49A
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
81 35415256 S87G
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
82 35415256 S87H
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
83 35415256 S87R
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
84 35415256 S87T
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
85 35415256 T128L
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
86 35415256 T12S
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
87 35415256 T146S
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
88 35415256 T147A
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
89 35415256 T147C
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
90 35415256 T147N
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
91 35415256 T67N
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
92 35415256 T67S
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
93 35415256 T91E
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
94 35415256 T91S
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
95 35415256 V13L
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
96 35415256 V149I
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
I
C
L
 View
97 35415256 V27L
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
98 35415256 V72W
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
99 35415256 VI149
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
100 35415256 W62C
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
101 35415256 W71G
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
102 35415256 Y132T
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
103 35415256 Y25F
PreC;C
C
Carcinoma, Hepatocellular
Hepatitis B Virus Infection
Hepatitis B, Chronic
Liver Cirrhosis
G
S
C
L
 View
Contents
Description

The table shows all curated mutation sites of HBV in each literature

Table Description Column Note
D
The study mentioned a certain treatment method, such as drug resistance caused by mutations.
G
The study mentioned the virus genotype/subtype information.
R
The study mentioned the reference sequence used for comparison, or the original strain of the virus used for site-directed mutagenesis.
S
The study provided sequence information or accession numbers.
L
The study provided the geographic region/country of data origin.
C
The study provided clinical baseline information.
I
The study involved information related to immune.
T
The study involved host target genes.