All Curated Mutation Sites in HBV 
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 The Virus Mutation(VM) module provides researchers the annotations of reported pathogenic mutations in HBV related to human diseases. The curated VM information includes mutation site, mutation level, virus gene/protein/region, virus-associated disease, genotype/subtype, literature evidence, etc.


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S
  
BCP
  
X
  
C
  
Core Promoter
  
Core Upstream Regulatory Sequence
  
DR1
  
EnhI
  
EnhII
  
PreC
  
P
  
PreC Promoter
  
PreS
  
PreS1
  
PreS1 Promoter
  
PreS2
  
RT
  
S Promoter
  
S1 Promoter
  
S2 Promoter
  
X Promoter
  

Keyword: Hepatitis B Virus Infection-25503289
ID PMID Mutation Gene/Protein/Region Encoding Gene/Protein Disease Description Detail
1 25503289 D144E
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
2 25503289 G145R
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
3 25503289 T779G
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
4 25503289 L209V
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
5 25503289 L84L
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
6 25503289 L94L
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
7 25503289 A410T
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
8 25503289 A482C
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
9 25503289 A555T
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
10 25503289 A753C
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
11 25503289 A771T
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
12 25503289 C531G
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
13 25503289 C533T
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
14 25503289 C586A
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
15 25503289 C720T
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
16 25503289 G587A
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
17 25503289 G765A
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
18 25503289 G772T
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
19 25503289 G774A
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
20 25503289 I110L
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
21 25503289 I86F
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
22 25503289 I92T
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
23 25503289 L213F
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
24 25503289 L213I
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
25 25503289 P127S
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
26 25503289 S143T
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
27 25503289 S204R
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
28 25503289 S207N
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
29 25503289 S210R
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
30 25503289 T126S
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
31 25503289 T189I
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
32 25503289 T429C
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
33 25503289 T484G
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
34 25503289 T581A
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
35 25503289 T784A
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
36 25503289 T791A
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
37 25503289 Y134F
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
38 25503289 Y200F
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
39 25503289 Y206L
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
40 25503289 A903G
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
41 25503289 A987C
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
42 25503289 A994C
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
43 25503289 C885T
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
44 25503289 G258G
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
45 25503289 G933A
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
46 25503289 K268K
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
47 25503289 R289R
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
48 25503289 Y252Y
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
49 25503289 A123A
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
50 25503289 A457G
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
51 25503289 C562A
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
52 25503289 C619T
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
53 25503289 Q101Q
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
54 25503289 S113S
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
55 25503289 S136S
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
56 25503289 S155S
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
57 25503289 S210S
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
58 25503289 T115T
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
59 25503289 T493A
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
60 25503289 T493C
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
61 25503289 T493G
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
62 25503289 T499A
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
63 25503289 T499C
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
64 25503289 T538A
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
65 25503289 T784C
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
66 25503289 A753T
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
67 25503289 A771C
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
68 25503289 C528T
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
69 25503289 C762A
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
70 25503289 P203Q
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
71 25503289 T125M
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
72 25503289 T766A
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
73 25503289 T770A
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
74 25503289 Y206T
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
75 25503289 A616G
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
76 25503289 S154S
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
77 25503289 T126T
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
78 25503289 T532C
S
S
Hepatitis B Virus Infection
G
R
S
I
L
View
79 25503289 A533C
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
80 25503289 A533T
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
81 25503289 A793T
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
82 25503289 A871C
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
83 25503289 A965C
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
84 25503289 C256S
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
85 25503289 C400A
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
86 25503289 C823A
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
87 25503289 D263E
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
88 25503289 F122I
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
89 25503289 F221Y
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
90 25503289 G950A
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
91 25503289 H124Y
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
92 25503289 H94I
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
93 25503289 I266K
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
94 25503289 L115V
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
95 25503289 L145M
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
96 25503289 L91I
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
97 25503289 M309K
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
98 25503289 N248H
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
99 25503289 N279T
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
100 25503289 P237T
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
101 25503289 R110G
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
102 25503289 R153K
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
103 25503289 R153Q
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
104 25503289 R274K
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
105 25503289 S137T
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
106 25503289 S219P
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
107 25503289 T1055A
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
108 25503289 T222S
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
109 25503289 T472G
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
110 25503289 T895A
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
111 25503289 T918A
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
112 25503289 T926A
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
113 25503289 T926G
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
114 25503289 Y135F
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
115 25503289 Y135S
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
116 25503289 A853C
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
117 25503289 A906C
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
118 25503289 C888A
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
119 25503289 C987A
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
120 25503289 C987G
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
121 25503289 C987T
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
122 25503289 G909A
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
123 25503289 G969A
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
124 25503289 H117H
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
125 25503289 L168L
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
126 25503289 L260L
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
127 25503289 Q215Q
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
128 25503289 R242R
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
129 25503289 R280R
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
130 25503289 S259S
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
131 25503289 T907A
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
132 25503289 T907C
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
133 25503289 V142V
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
134 25503289 V253V
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
135 25503289 V286V
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
136 25503289 I163V
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
137 25503289 S213T
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
138 25503289 V214D
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
139 25503289 Y135H
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
140 25503289 A211A
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
141 25503289 G852A
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
142 25503289 H134H
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
143 25503289 K241K
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
144 25503289 V208V
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
145 25503289 A436G
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
146 25503289 A886G
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
147 25503289 A952G
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
148 25503289 C406T
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
149 25503289 G779T
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
150 25503289 I103V
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
151 25503289 I253V
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
152 25503289 K275E
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
153 25503289 L217R
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
154 25503289 L93F
RT
P
Hepatitis B Virus Infection
G
R
S
L
View
Contents
Description

The table shows all curated mutation sites of HBV in each literature

Table Description Column Note
D
The study mentioned a certain treatment method, such as drug resistance caused by mutations.
G
The study mentioned the virus genotype/subtype information.
R
The study mentioned the reference sequence used for comparison, or the original strain of the virus used for site-directed mutagenesis.
S
The study provided sequence information or accession numbers.
L
The study provided the geographic region/country of data origin.
C
The study provided clinical baseline information.
I
The study involved information related to immune.
T
The study involved host target genes.