All Curated Mutation Sites in HBV 
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 The Virus Mutation(VM) module provides researchers the annotations of reported pathogenic mutations in HBV related to human diseases. The curated VM information includes mutation site, mutation level, virus gene/protein/region, virus-associated disease, genotype/subtype, literature evidence, etc.


Browse Data by Virus Gene/Protein/Region, Disease OR Description
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For highly variable viruses (e.g., HBV, HIV, SARS-CoV-2), ViMIC defaults to displaying mutations in a specific region. Click the green button to search for other regions, or click "Show All" to view all mutations (loading speed may be affected by network conditions).

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S
  
BCP
  
X
  
C
  
Core Promoter
  
Core Upstream Regulatory Sequence
  
DR1
  
EnhI
  
EnhII
  
PreC
  
P
  
PreC Promoter
  
PreS
  
PreS1
  
PreS1 Promoter
  
PreS2
  
RT
  
S Promoter
  
S1 Promoter
  
S2 Promoter
  
X Promoter
  

Keyword: Hepatitis B Virus Infection-35102169
ID PMID Mutation Gene/Protein/Region Encoding Gene/Protein Disease Description Detail
1 35102169 L180M
RT
P
Hepatitis B Virus Infection
D
G
I
C
L
View
2 35102169 M204I
RT
P
Hepatitis B Virus Infection
D
G
I
C
L
View
3 35102169 M204V
RT
P
Hepatitis B Virus Infection
D
G
I
C
L
View
4 35102169 A194V
S
S
Hepatitis B Virus Infection
G
I
C
L
View
5 35102169 A297P
RT
P
Hepatitis B Virus Infection
G
C
L
View
6 35102169 A307C
RT
P
Hepatitis B Virus Infection
G
C
L
View
7 35102169 A38A
RT
P
Hepatitis B Virus Infection
G
C
L
View
8 35102169 D144A
S
S
Hepatitis B Virus Infection
G
I
C
L
View
9 35102169 D271E
RT
P
Hepatitis B Virus Infection
G
C
L
View
10 35102169 F134L
S
S
Hepatitis B Virus Infection
G
I
C
L
View
11 35102169 F296I
RT
P
Hepatitis B Virus Infection
G
C
L
View
12 35102169 G44E
S
S
Hepatitis B Virus Infection
G
I
C
L
View
13 35102169 H122Y
RT
P
Hepatitis B Virus Infection
G
C
L
View
14 35102169 H271Q
RT
P
Hepatitis B Virus Infection
G
C
L
View
15 35102169 H35Q
RT
P
Hepatitis B Virus Infection
G
C
L
View
16 35102169 I208T
S
S
Hepatitis B Virus Infection
G
I
C
L
View
17 35102169 I253V
RT
P
Hepatitis B Virus Infection
G
C
L
View
18 35102169 I53L
RT
P
Hepatitis B Virus Infection
G
C
L
View
19 35102169 I53S
RT
P
Hepatitis B Virus Infection
G
C
L
View
20 35102169 I68T
S
S
Hepatitis B Virus Infection
G
I
C
L
View
21 35102169 I81I
S
S
Hepatitis B Virus Infection
G
I
C
L
View
22 35102169 K122R
S
S
Hepatitis B Virus Infection
G
I
C
L
View
23 35102169 K212T
RT
P
Hepatitis B Virus Infection
G
C
L
View
24 35102169 L109V
S
S
Hepatitis B Virus Infection
G
I
C
L
View
25 35102169 L49P
S
S
Hepatitis B Virus Infection
G
I
C
L
View
26 35102169 M103I
S
S
Hepatitis B Virus Infection
G
I
C
L
View
27 35102169 M129L
RT
P
Hepatitis B Virus Infection
G
C
L
View
28 35102169 M133I
S
S
Hepatitis B Virus Infection
G
I
C
L
View
29 35102169 N122H
RT
P
Hepatitis B Virus Infection
G
C
L
View
30 35102169 N123D
RT
P
Hepatitis B Virus Infection
G
C
L
View
31 35102169 N238T
RT
P
Hepatitis B Virus Infection
G
C
L
View
32 35102169 N246S
RT
P
Hepatitis B Virus Infection
G
C
L
View
33 35102169 P214L
S
S
Hepatitis B Virus Infection
G
I
C
L
View
34 35102169 P46H
S
S
Hepatitis B Virus Infection
G
I
C
L
View
35 35102169 Q125K
RT
P
Hepatitis B Virus Infection
G
C
L
View
36 35102169 Q215H
RT
P
Hepatitis B Virus Infection
G
C
L
View
37 35102169 R110G
RT
P
Hepatitis B Virus Infection
G
C
L
View
38 35102169 S109P
RT
P
Hepatitis B Virus Infection
G
C
L
View
39 35102169 S117C
RT
P
Hepatitis B Virus Infection
G
C
L
View
40 35102169 S135F
RT
P
Hepatitis B Virus Infection
G
C
L
View
41 35102169 S137T
RT
P
Hepatitis B Virus Infection
G
C
L
View
42 35102169 S159T
RT
P
Hepatitis B Virus Infection
G
C
L
View
43 35102169 S174N
S
S
Hepatitis B Virus Infection
G
I
C
L
View
44 35102169 S193L
S
S
Hepatitis B Virus Infection
G
I
C
L
View
45 35102169 S204N
S
S
Hepatitis B Virus Infection
G
I
C
L
View
46 35102169 S207N
S
S
Hepatitis B Virus Infection
G
I
C
L
View
47 35102169 S207T
S
S
Hepatitis B Virus Infection
G
I
C
L
View
48 35102169 S210R
S
S
Hepatitis B Virus Infection
G
I
C
L
View
49 35102169 S219A
RT
P
Hepatitis B Virus Infection
G
C
L
View
50 35102169 S34L
S
S
Hepatitis B Virus Infection
G
I
C
L
View
51 35102169 S45A
S
S
Hepatitis B Virus Infection
G
I
C
L
View
52 35102169 S61L
S
S
Hepatitis B Virus Infection
G
I
C
L
View
53 35102169 T118A
S
S
Hepatitis B Virus Infection
G
I
C
L
View
54 35102169 T118N
RT
P
Hepatitis B Virus Infection
G
C
L
View
55 35102169 T189I
S
S
Hepatitis B Virus Infection
G
I
C
L
View
56 35102169 T237A
RT
P
Hepatitis B Virus Infection
G
C
L
View
57 35102169 T259A
RT
P
Hepatitis B Virus Infection
G
C
L
View
58 35102169 T259S
RT
P
Hepatitis B Virus Infection
G
C
L
View
59 35102169 T313A
RT
P
Hepatitis B Virus Infection
G
C
L
View
60 35102169 V112I
RT
P
Hepatitis B Virus Infection
G
C
L
View
61 35102169 V142A
RT
P
Hepatitis B Virus Infection
G
C
L
View
62 35102169 V168A
S
S
Hepatitis B Virus Infection
G
I
C
L
View
63 35102169 V180A
S
S
Hepatitis B Virus Infection
G
I
C
L
View
64 35102169 V184A
S
S
Hepatitis B Virus Infection
G
I
C
L
View
65 35102169 V214G
RT
P
Hepatitis B Virus Infection
G
C
L
View
66 35102169 V278I
RT
P
Hepatitis B Virus Infection
G
C
L
View
67 35102169 V96A
S
S
Hepatitis B Virus Infection
G
I
C
L
View
68 35102169 W153R
RT
P
Hepatitis B Virus Infection
G
C
L
View
69 35102169 Y100C
S
S
Hepatitis B Virus Infection
G
I
C
L
View
70 35102169 Y126C
RT
P
Hepatitis B Virus Infection
G
C
L
View
71 35102169 Y161F
S
S
Hepatitis B Virus Infection
G
I
C
L
View
72 35102169 Y206V
S
S
Hepatitis B Virus Infection
G
I
C
L
View
Contents
Description

The table shows all curated mutation sites of HBV in each literature

Table Description Column Note
D
The study mentioned a certain treatment method, such as drug resistance caused by mutations.
G
The study mentioned the virus genotype/subtype information.
R
The study mentioned the reference sequence used for comparison, or the original strain of the virus used for site-directed mutagenesis.
S
The study provided sequence information or accession numbers.
L
The study provided the geographic region/country of data origin.
C
The study provided clinical baseline information.
I
The study involved information related to immune.
T
The study involved host target genes.